ANSAMITOCIN P-3
- Product Name
- ANSAMITOCIN P-3
- CAS No.
- 66547-09-9
- Chemical Name
- ANSAMITOCIN P-3
- Synonyms
- ASMP-3;CS-1373;c15003p-3’;Aansamitocin P3;ANSAMITOCIN P-N;Maytansinoid AP-3;antibioticc15003p3’;maytansinolbutyrate;Ansamitocin P-3, >=70%;Ansamitocin P-3 (≥90%)
- CBNumber
- CB6205964
- Molecular Formula
- C32H43ClN2O9
- Formula Weight
- 635.14
- MOL File
- 66547-09-9.mol
ANSAMITOCIN P-3 Property
- Melting point:
- 182-185℃
- Boiling point:
- 837.6±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
- pka
- 9.83±0.70(Predicted)
- form
- White to off-white crystalline solid.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- OQ2293000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20538
- Product name
- Ansamitocin P-3
- Purity
- ≥85%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 20538
- Product name
- Ansamitocin P-3
- Purity
- ≥85%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 20538
- Product name
- Ansamitocin P-3
- Purity
- ≥85%
- Packaging
- 10mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 20538
- Product name
- Ansamitocin P-3
- Purity
- ≥85%
- Packaging
- 25mg
- Price
- $669
- Updated
- 2024/03/01
- Product number
- A678300
- Product name
- AnsamitocinP-3’(≥90%)
- Packaging
- 25mg
- Price
- $195
- Updated
- 2021/12/16
ANSAMITOCIN P-3 Chemical Properties,Usage,Production
Description
Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.
Uses
Ansamitocin P-3’ is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic.
References
1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722 2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding Tubulin at the Vinblastine Site; PLoS ONE 8 e75182 3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia, 46 117 4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707
ANSAMITOCIN P-3 Preparation Products And Raw materials
Raw materials
Preparation Products
ANSAMITOCIN P-3 Suppliers
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View Lastest Price from ANSAMITOCIN P-3 manufacturers
- Product
- Ansamitocin P-3 66547-09-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-09
- Product
- Ansamitocin P-3 66547-09-9
- Price
- US $10.00/g/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 100KG
- Release date
- 2021-11-16
- Product
- Ansamitocin P-3" 66547-09-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11