ChemicalBook > CAS DataBase List > ANSAMITOCIN P-3

ANSAMITOCIN P-3

Product Name
ANSAMITOCIN P-3
CAS No.
66547-09-9
Chemical Name
ANSAMITOCIN P-3
Synonyms
ASMP-3;CS-1373;c15003p-3’;Aansamitocin P3;ANSAMITOCIN P-N;Ansamitocin P 3';Maytansinoid AP-3;antibioticc15003p3’;maytansinolbutyrate;Ansamitocin P-3, >=70%
CBNumber
CB6205964
Molecular Formula
C32H43ClN2O9
Formula Weight
635.14
MOL File
66547-09-9.mol
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ANSAMITOCIN P-3 Property

Melting point:
182-185℃
Boiling point:
837.6±65.0 °C(Predicted)
Density 
1.30±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
pka
9.83±0.70(Predicted)
form 
White to off-white crystalline solid.
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey
OPQNCARIZFLNLF-JZXROFAFNA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
OQ2293000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20538
Product name
Ansamitocin P-3
Purity
≥85%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
20538
Product name
Ansamitocin P-3
Purity
≥85%
Packaging
5mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
20538
Product name
Ansamitocin P-3
Purity
≥85%
Packaging
10mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
20538
Product name
Ansamitocin P-3
Purity
≥85%
Packaging
25mg
Price
$669
Updated
2024/03/01
TRC
Product number
A678300
Product name
AnsamitocinP-3’(≥90%)
Packaging
25mg
Price
$195
Updated
2021/12/16
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ANSAMITOCIN P-3 Chemical Properties,Usage,Production

Description

Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.

Uses

Ansamitocin P-3’ is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic.

References

[1] YIN LI. Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: Differential interactions of these antimitotic agents with brain and fungal tubulins[J]. Biochemical and biophysical research communications, 1992, 187 2: Pages 722-729. DOI:10.1016/0006-291x(92)91255-o
[2] JUBINA B VENGHATERI. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site.[J]. PLoS ONE, 2013: e75182. DOI:10.1371/journal.pone.0075182
[3] K SUWANBORIRUX. Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes.[J]. Experientia, 1990, 46 1: 117-120. DOI:10.1007/bf01955435
[4] K OOTSU. Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.[J]. Cancer research, 1980, 40 5: 1707-1717.

ANSAMITOCIN P-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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ANSAMITOCIN P-3 Suppliers

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View Lastest Price from ANSAMITOCIN P-3 manufacturers

Wuhan Demeikai Biotechnology Co., Ltd
Product
Ansamitocin P-3 66547-09-9
Price
US $10.00/g/Bag
Min. Order
10g
Purity
99
Supply Ability
100KG
Release date
2021-11-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ansamitocin P-3" 66547-09-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Longyan Tianhua Biological Technology Co., Ltd
Product
ANSAMITOCIN P-3 66547-09-9
Price
US $3.00/mg/ml
Min. Order
1mg/ml
Purity
99%
Supply Ability
10kg
Release date
2020-10-23

66547-09-9, ANSAMITOCIN P-3Related Search:

ansamitocin P-3 NOCODAZOLE MYOSEVERIN 2-CHLORO-5-METHYLPHENOL Phenol, 3-amino-2-chloro- 8,10-DODECADIEN-1-OL 2-Chloro-3-methoxyaniline ANSAMITOCIN P-3 3-[(3-N,N-DIMETHYLAMINO)PHENYL]-1-PROPENE (S)-2-Methyl Glycidol 4-(3-METHOXY-PHENYLAMINO)-BUTAN-1-OL Acetamide, N-(2-chloro-3-methoxyphenyl)- 4-chloro-3-methoxytoluene 2-CHLORO-5-ETHYLPHENOL hedonal (S)-3,4-DIHYDROXYBUTYRAMIDE RARECHEM AN KD 0246 Maytansine, O3-acetyl-O3-de2-(acetylmethylamino)-1-oxopropyl-22-demethyl-

  • 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-maytansinbutyrate(ester
  • Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
  • Maytansine, o(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup 3)-(1-oxobutyl)- (9ci)
  • Ansamitocin P-3, >=70%
  • Maytansinoid AP-3
  • ANSAMITOCIN P-N
  • Aansamitocin P3
  • ANTIBIOTIC C 15003P3; MAYTANSINOL BUTYRATE; C15003P3
  • CS-1373
  • ANTIBIOTIC C 15003P3';MAYTANSINOL BUTYRATE
  • 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansinebutyrate(ester)
  • antibioticc15003p3’
  • c15003p-3’
  • maytansine,o(sup3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup3)-(1-oxobut
  • maytansinolbutyrate
  • ASMP-3
  • ANSAMITOCIN P-3, ACTINOSYNNEMA PRETIOSUM
  • ANSAMITOCIN P-3 FROM ACTINOSYNNEMAPRETIO SUM
  • Maytansine, 2-de(acetylmethylamino)-2-methyl-
  • Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-O3-(1-oxobutyl)-
  • 3-O-De[2-[acetyl(methyl)amino]-1-oxopropyl]-3-O-(1-oxobutyl)maytansine
  • Ansamitocin P-3 (≥90%)
  • Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-
  • Maytansinol Impurity 1 (Maytansinol Butyrate)(Ansamitocin P-3)
  • TIANFUCHEM--66547-09-9---ANSAMITOCIN P-3
  • Ansamitocin P 3'
  • Ansamitocin P-3, microtubule depolymerizing agent
  • Ansamitocin P 3'', 10 mM in DMSO
  • 3-o-De[2-(N-Acetyl-N-methylamino)-1-oxo-propyl]-3-o-(1-oxo-butyl)maytansine
  • 66547-09-9
  • 65547-09-9
  • C32H43ClN2O9
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Microtobule Inhibitors
  • Cytoskeleton and Extracellular Matrix
  • Inhibitors
  • Cell Signaling and Neuroscience
  • Cytoskeleton and Extracellular Matrix
  • Microtobule Inhibitors
  • Microtobule Inhibitors
  • Cell Signaling and Neuroscience
  • Cytoskeleton and Extracellular Matrix