ChemicalBook > CAS DataBase List > 3,5-Bis(trifluoromethyl)benzeneboronic acid

3,5-Bis(trifluoromethyl)benzeneboronic acid

Product Name: 3,5-Bis(trifluoromethyl)benzeneboronic acid
CAS No.: 73852-19-4
Chemical Name: 3,5-Bis(trifluoromethyl)benzeneboronic acid
Synonyms: 3,5-BIS(TRIFLUOROMETHYL)PHENYLBORONIC ACID;AKOS BRN-0072;RARECHEM AH PB 0029;3,5-BIS(TRIFLUOROMETHYL)PHENYLBORONIC;3,5-Bis(trifluoroMethyl)benzeneboronic;5-Bis(trifluoroMethyl)phenylboronic acid;3,5-Bis(trifloroMethyl)phenylboronic acid;3,5-DI(TRIFLUOROMETHYL)PHENYLBORONIC ACID;3,5--TrifluoroMethyl benzene boronic acid;3,5-BIS(TRIFLUOROMETHYL)PHENYLBOROIC ACID
CBNumber: CB6205984
Molecular Formula: C8H5BF6O2
Formula Weight: 257.93
MOL File: 73852-19-4.mol

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3,5-Bis(trifluoromethyl)benzeneboronic acid Property

Melting point:: 217-220 °C (lit.)
Boiling point:: 248.1±50.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystals or Powder
pka: 6.57±0.10(Predicted)
color: White to light yellow
BRN: 7379990
InChI: InChI=1S/C8H5BF6O2/c10-7(11,12)4-1-5(8(13,14)15)3-6(2-4)9(16)17/h1-3,16-17H
InChIKey: BPTABBGLHGBJQR-UHFFFAOYSA-N
SMILES: B(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(O)O
CAS DataBase Reference: 73852-19-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
TSCA: No
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 471070
Product name: 3,5-Bis(trifluoromethyl)phenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $78.27
Updated: 2025/07/31

TCI Chemical

Product number: B1886
Product name: 3,5-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: B1886
Product name: 3,5-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $58
Updated: 2025/07/31

TCI Chemical

Product number: B1886
Product name: 3,5-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $172
Updated: 2025/07/31

TRC

Product number: B412868
Product name: 3,5-Bis(trifluoromethyl)phenylboronic acid
Packaging: 5g
Price: $55
Updated: 2021/12/16

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3,5-Bis(trifluoromethyl)benzeneboronic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

suzuki reaction

Uses

Reactant involved in the synthesis of:

Methylene-arylbutenones via carbonylative arylation of allenols
4-aminoquinoline analogs via Ullman / Suzuki / Negishi coupling
Primary amino acid derivatives with anticonvulsant activity
Alkyl arylcarbamates via Cu-catalyzed coupling with potassium cyanate
Aryl-substituted succinimides and cyclic ketones by asymmetric conjugate addition
Axially chiral dicarboxylic acids for asymmetric Mannich-type reactions

Synthesis

121-43-7

328-70-1

7732-18-5

73852-19-4

General procedure for the synthesis of 3,5-bis(trifluoromethyl)benzeneboronic acid from trimethyl borate, 3,5-bis(trifluoromethyl)bromobenzene, and electrophoretic-grade water: in a three-necked, dry, round-bottomed flask equipped with a rod-shaped magnetic stirrer, a 500-ml dropping funnel, condenser tube, and nitrogen introduction tube, 9.30 g of magnesium flakes were added under nitrogen protection and 220 ml of tetrahydrofuran (THF), which had been distillate-purified, were added ). The temperature of the reaction system was maintained in the range of 0 to 5°C by means of an ice bath. At this temperature, 44.0 mL of 3,5-bis(trifluoromethyl)bromobenzene was slowly added through a dropping funnel and the addition process was controlled to be completed within 1 hour. After the addition was completed, the reaction was slowly warmed to room temperature and continued for 16 hours to obtain a dark brown viscous solution. Subsequently, the reaction solution was cooled to -70°C in a dry ice/acetone bath and 28.97 mL of trimethyl borate was slowly added dropwise through a dropping funnel. After completion of the dropwise addition, the reaction solution was allowed to warm naturally to room temperature and the reaction was continued for 12 hours to obtain a brown viscous solution. Under cooling in an ice bath, 144.5 ml of 37 wt% aqueous hydrochloric acid solution was mixed with 63.3 ml of distilled water and slowly added to the reaction solution over a period of 1 hour, after which the reaction was continued for 24 hours. Upon completion of the reaction, the red organic layer was separated using a partition funnel. The organic layer was concentrated under reduced pressure to remove the solvent and the solid residue obtained was purified by recrystallization in distilled water. The resulting white crystals were collected, washed with petroleum ether and dried at room temperature for 24 hours to afford the target product 3,5-bis(trifluoromethyl)benzeneboronic acid (6FBB) (19.44 g, yield: 85%).

References

[1] Patent: KR2015/112649, 2015, A. Location in patent: Paragraph 0089; 0093-0095

3,5-Bis(trifluoromethyl)benzeneboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Bis(trifluoromethyl)benzeneboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-Bis(trifluoromethyl)benzeneboronic acid 73852-19-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

Career Henan Chemical Co

Product: 3,5-Bis(trifluoromethyl)benzeneboronic acid 73852-19-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-03

73852-19-4, 3,5-Bis(trifluoromethyl)benzeneboronic acidRelated Search:

2,4-Bis(trifluoromethyl)benzeneboronic acid pinacol ester 2,4-Bis(trifluoromethyl)benzeneboronic acid 98%,2,4-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID,2,4-Bis(trifluoromethyl)benzeneboronic acid, 97+% 2,5-Bis-Thiopheneboronic acid pinacol ester 3,4-Bis(trifluoroMethyl)phenylboronic acid 2,5-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID,2,5-BIS(TRIFLUOROMETHYL)-BENZENEBORONIC ACID, 97+% METHYL FLUORIDE ((4S,5S)-(-)-O-[1-BENZYL-1-(5-METHYL-2-PHENYL-4,5-DIHYDROOXAZOL-4-YL)-2-PHENYLETHYL]-DICYCLOHEXYL-PHOSPHINITE)(1,5-COD)IRIDIUM (I) TETRAKIS(3,5-BIS(TRIFLUOROMETHYL)PHENYLBORATE 2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID 3-(Trifluoromethyl)phenylboronic acid 3,5-Bis(trifluoromethyl)benzeneboronic acid Phenylboronic acid 3-Tolylboronic acid Methylboronic acid 1,3-Bis(trifluoromethyl)-benzene 3,5-Dimethylphenylboronic acid 3-(TRIFLUOROMETHYL)-5-METHYL-PHENYLBORONIC ACID 3-Difluoromethyl-phenylboronic acid

RARECHEM AH PB 0029

3,5-Bis(trifluoromethyl)benzeneboronic acid, 97+%

3,5-Bis(trifluoromethyl)phenylboranic acid

Boric acid 3,5-bis(trifluoromethyl)phenyl ester

3,5-Bis(trifluoromethyl)benzeneboronic acid,95%

3,4-Bis(trifluoromethyl) phenylboronic acid

5-Bis(trifluoroMethyl)phenylboronic acid

3,5-Bis(trifloroMethyl)phenylboronic acid

3,5-Bis(trifluoroMethyl)benzeneboronic acid, 95% 1GR

3,5-BIS(TRIFLUOROMETHYL)PHENYLBORONIC ACID(CONTAINS VARYING AMOUNTS OF ANHYDRIDE)

3,5-Bis(trifluoromethyl)benzeneboronic acid, 99% [3,5-Bis(trifluoromethyl)phenylboronic acid]

3,5-Bis(trifluoromethyl)benzeneboronic acid 98%

3,5-Bis(trifluoromethyl)benzeneboronicacid98%

3,5-DI(TRIFLUOROMETHYL)PHENYLBORONIC ACID

3,5-Bis(trifluoroMethyl)benzeneboronic

3,5-Di(trifluoromethyl)benzeneboronic acid

3,5-Bis(trifluoroMethyl)benzeneboronic acid (contains varying aMounts of anhydride)

3,5--TrifluoroMethyl benzene boronic acid

AKOS BRN-0072

3,5-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID

3,5-BIS(TRIFLUOROMETHYL)PHENYLBOROIC ACID

3,5-BIS(TRIFLUOROMETHYL)PHENYLBORONIC ACID

3,5-bis-(Trifluoromethyl)benzenboric acid

3,5-bis-(Trifluoromethyl)phenylboric acid

3,5-BIS(TRIFLUOROMETHYL)PHENYLBORONIC

Boronic acid, B-[3,5-bis(trifluoromethyl)phenyl]-

3,5-Bis(trifluoromethyl)phenylboronic acid 98%

3,5-Bis(trifluoromethyl)phenylboronic acid - [B1800]

73852-19-4

C8H5O2BF6

CF32C6H3BOH2

C8H5BF6O2

Organometallic Reagents

Boronic Acids

B (Classes of Boron Compounds)

BORONIC ACID

Boronic Acids and Derivatives

Aryl

Substituted Boronic Acids

blocks

BoronicAcids

FluoroCompounds

Boric Acid

Boronic Acid series

Fluorides

Fluorin-contained phenyl boronic acid series

Boronic Acids

Boronic Acids and Derivatives

Boronic Acid

B (Classes of Boron Compounds)

Boronic Acids

Aryl

Organoborons

Trifluoromethyl

Boronate Ester

Potassium Trifluoroborate