Pitavastatin
Description Reference- Product Name
- Pitavastatin
- CAS No.
- 147511-69-1
- Chemical Name
- Pitavastatin
- Synonyms
- ITAVASTATIN;PITVASTATIN;PITAVASTATIN;PitavastatinCa;Compound T7072;pitavastatin(1-);Pitavastatin API;Pitavastatin Acid;Atorvastatin therapy;PITAVASTATIN (NK-104)
- CBNumber
- CB6206668
- Molecular Formula
- C25H24FNO4
- Formula Weight
- 421.46
- MOL File
- 147511-69-1.mol
Pitavastatin Property
- Melting point:
- 182 - 185°C
- Boiling point:
- 692.0±55.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, Hygroscopic
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.24±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 147511-69-1(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)- (147511-69-1)
Safety
- Hazardous Substances Data
- 147511-69-1(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B1124
- Product name
- Pitavastatin
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B1124
- Product name
- Pitavastatin
- Packaging
- 25mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FP65047
- Product name
- Pitavastatin
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FP65047
- Product name
- Pitavastatin
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FP65047
- Product name
- Pitavastatin
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
Pitavastatin Chemical Properties,Usage,Production
Description
Pitavastatin (Brand Name: LIVALO) is an inhibitor of HMG-CoA reductase which catalyzes the first step of cholesterol synthesis. It appears as odorless and white to pale-yellow powder. It takes effects by reducing the level of certain fatty substances such as cholesterol in the body. Therefore, it is mainly indicated for the treatment of hypercholesterolaemia and for the prevention of cardiovascular diseases. It can not only lower the high cholesterol and triglyceride in certain patients, but also can increase the content of high density lipoprotein (HDL), the “good” cholesterol levels. It should be generally administrated together with a proper diet.
Reference
https://en.wikipedia.org/wiki/Pitavastatin
http://www.rxlist.com/livalo-drug.htm
https://www.drugs.com/cdi/pitavastatin.html
Uses
HMGA reductase inhibitor
Definition
ChEBI: A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
brand name
[Name previously used: Itavastatin].
Biological Activity
pitavastatin (nk-104) is a potent hmg-coa reductase inhibitor, pitavastatin inhibited cholesterol synthesis from acetic acid with an ic50 of 5.8 nm in a human liver cancer cell line (hepg2).
Enzyme inhibitor
This HMG-CoA reductase inhibitor (FW = 421.46 g/mol; CAS 147511-69- 1; IUPAC Name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin- 3-yl]-3,5-dihydroxyhept-6-enoic acid), also known as itavastatin, itabavastin, nisvastatin, NK-104, NKS-104, and the trade name Livalo?, is indicated for ameliorating hypercholesterolemia and preventing cardiovascular disease. NK-104 potency is dose-dependent and is roughly equivalent to that of atorvastatin. It is well-tolerated in the treatment of patients with hypercholesterolemia. Pitavastatin uptake is carrier-mediated. Target(s): Reduces inflammatory cytokine production from human bronchial epithelial cells; Decreases microtubule tau protein levels via the inactivation of Rho/ROCK; Inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model; Suppresses therosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolemic rabbits; Decreases the expression of endothelial lipase both in vitro and in vivo; Inhibits NFkB pathway in brain; Inactivates NFkB and decreases IL-6 production through Rho kinase pathway in MCF-7 human breast cancer cells; Reduces C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells; Inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation; Inhibits upregulation of intermediate conductance calcium-activated potassium channels and coronary arteriolar remodeling induced by long-term blockade of nitric oxide synthesis; Inhibits migration and proliferation of rat vascular smooth muscle cells.
Pitavastatin Preparation Products And Raw materials
Raw materials
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View Lastest Price from Pitavastatin manufacturers
- Product
- Pitavastatin 147511-69-1
- Price
- US $60.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 2000MT
- Release date
- 2023-01-11
- Product
- Atorvastatin therapy 147511-69-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-12
- Product
- Pitavastatin 147511-69-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10