ChemicalBook > CAS DataBase List > 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID

2-CHLOROQUINOLINE-4-CARBOXYLIC ACID

Product Name
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
CAS No.
5467-57-2
Chemical Name
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
Synonyms
Nsc25654;AKOS BB-6908;2-Chlorocinchoninic acid;A-CHLORO CINCHONINIC ACID;2-CHLORO-4-CARBOXY QUINOLINE;2-Chloroquinoline-4-CarboxylicAci;2-Chloro-4-quinolinecarboxylic acid;2-CHLOROQUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 2-chloro-;2-Chloroquinoline-4-carboxylic Acid >
CBNumber
CB6208905
Molecular Formula
C10H6ClNO2
Formula Weight
207.61
MOL File
5467-57-2.mol
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2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Property

Melting point:
244 °C
Boiling point:
368.7±22.0 °C(Predicted)
Density 
1.469±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.17±0.10(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C10H6ClNO2/c11-9-5-7(10(13)14)6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14)
InChIKey
ICNCOMYUODLTAI-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2)C(C(O)=O)=CC=1Cl
CAS DataBase Reference
5467-57-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933491090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1703
Product name
2-Chloroquinoline-4-carboxylic Acid
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$155
Updated
2025/07/31
TCI Chemical
Product number
C1703
Product name
2-Chloroquinoline-4-carboxylic Acid
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$569
Updated
2025/07/31
TRC
Product number
C381460
Product name
2-Chloroquinoline-4-carboxylic Acid
Packaging
5g
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC15904
Product name
2-Chloroquinoline-4-carboxylic acid
Packaging
100g
Price
$1155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC15904
Product name
2-Chloroquinoline-4-carboxylic acid
Packaging
25g
Price
$394
Updated
2021/12/16
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2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

2-Chloroquinoline-4-carboxylic Acid is an intermediate used to prepare dimethyl(naphthalenecarbonyl)aminobenzoic acids as potent and selective EP4 antagonists.

Synthesis

15733-89-8

5467-57-2

The general procedure for the synthesis of 2-chloroquinoline-4-carboxylic acid from 2-quinolone-4-carboxylic acid was as follows: 2-hydroxyquinoline-4-carboxylic acid (2.57 g, 13.6 mmol) was mixed with phosphorus oxytriphosphate (POCl3, 25 mL) and heated and refluxed for 24 hours. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into crushed ice (300 g). The precipitated solid was separated by filtration, washed thoroughly with deionized water and dried under high vacuum to give 2.47 g of white solid product in 87% yield. The product was characterized by 1H NMR (CDCl3, 300 MHz) and LCMS: 1H NMR δ 8.67 (d, 1H, J = 8.4 Hz), 7.91 (d, 1H, J = 8.1 Hz), 7.83 (s, 1H), 7.67 (t, 1H, J = 7.2 Hz), 7.54 (t, 1H, J = 7.2 Hz); LCMS (m/ z): 208 ([M+H]+).

References

[1] Patent: WO2005/30774, 2005, A1. Location in patent: Page/Page column 23
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1837,1838
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1938, vol. 125, p. 60,69

2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLOROQUINOLINE-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 5467-57-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-15
Career Henan Chemical Co
Product
2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 5467-57-2
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20ton
Release date
2019-12-20

5467-57-2, 2-CHLOROQUINOLINE-4-CARBOXYLIC ACIDRelated Search:

1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloroquinoline-3-carboxylic acid 4-chloroquinoline-7-carboxylic acid 7-chloroquinoline-4-carboxylic acid 7-CHLOROQUINOLINE-3-CARBOXYLIC ACID 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID 4-Hydroxy-7-chloroquinoline-3-carboxylic acid 6-Bromo-2-chloroquinoline-4-carboxylic acid,6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97 5-chloroquinoline-4-carboxylic acid 6-chloroquinoline-3-carboxylic acid 2-chloroquinoline-6-carboxylic acid 8-CHLOROQUINOLINE-3-CARBOXYLIC ACID 4-CHLOROQUINOLINE-2-CARBOXYLIC ACID 4-chloroquinoline-6-carboxylic acid QUINOLINE-4-CARBOXYLIC ACID 2-Chloroquinoline METHYL 2-CHLOROQUINOLINE-4-CARBOXYLATE METHYL 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLATE 2-CHLORO-6-METHYL-QUINOLINE-4-CARBOXYLIC ACID

  • AKOS BB-6908
  • A-CHLORO CINCHONINIC ACID
  • 2-CHLORO-4-CARBOXY QUINOLINE
  • 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
  • 2-chloroquinazoline-4-carboxylic acid ethyl ester
  • 4-Quinolinecarboxylic acid, 2-chloro-
  • Nsc25654
  • 2-Chlorocinchoninic acid
  • 4-Carboxy-2-chloroquinoline, alpha-Chlorocinchoninic acid
  • 4-Carboxy-2-chloroquinoline, 4-Carboxy-2-chloro-1-azanaphthalene
  • 2-Chloro-4-quinolinecarboxylic acid
  • 2-Chloroquinoline-4-carboxylic Acid &gt
  • 2-Chloroquinoline-4-CarboxylicAci
  • 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID ISO 9001：2015 REACH
  • 5467-57-2
  • Quinolines
  • Haloquinolines
  • CHIRAL CHEMICALS
  • Quinoline
  • Carboxylic Acids
  • Quinolines, Isoquinolines & Quinoxalines
  • Quinoline series
  • Carboxylic Acids
  • Quinolines, Isoquinolines & Quinoxalines
  • Haloquinolines
  • Quinolines