1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Product Name: 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
CAS No.: 68077-26-9
Chemical Name: 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
Synonyms: NORF-007;AKOS 1303;Norfloxacin Q-Acid;TIMTEC-BB SBB003042;Norfloxacin EP Imp A;Norfloxacin ImpurityⅠ;Norfloxacin Impurity 11;Norfloxacin EP Impurity A;Norfloxacincarboxylicacid;Norfloxacin impurity A CRS
CBNumber: CB6669991
Molecular Formula: C12H9ClFNO3
Formula Weight: 269.66
MOL File: 68077-26-9.mol

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1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:: 245°C
Boiling point:: 437.9±45.0 °C(Predicted)
Density: 1.3905 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: powder
pka: -0.21±0.20(Predicted)
color: White to Pale Yellow
InChIKey: WNNSMMJBBOPPOT-UHFFFAOYSA-N
CAS DataBase Reference: 68077-26-9(CAS DataBase Reference)

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Safety

Risk Statements: 52/53
Safety Statements: 61
HazardClass: IRRITANT
HS Code: 2933599550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R462462
Product name: 7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2233
Product name: Norfloxacin Related Compound A
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
Packaging: 100mg
Price: $652.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: N1230010
Product name: Norfloxacin impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $239
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1471517
Product name: Norfloxacin impurity A
Packaging: 15mg
Price: $1300
Updated: 2025/07/31

Sigma-Aldrich

Product number: R462462
Product name: 7-CHLORO-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
Purity: AldrichCPR
Packaging: 250MG
Price: $179
Updated: 2024/03/01

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1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid).

Synthesis

70458-94-5

68077-26-9

Ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.75 g, 9.24 mmol) was used as a raw material and dissolved in 60 mL of methanol. Subsequently, a 1:1 solution of hydrochloric acid (31.5 mL, 189 mmol) was added. The reaction mixture was heated to reflux for 2 h. Upon completion of the reaction, a white solid precipitated. The solid product was collected by filtration and washed with plenty of water. Finally, the product was dried in a vacuum oven for 2 h to afford 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-carbonylquinoline-3-carboxylic acid (2.46 g, yield: 89.5%).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4257 - 4265
[2] Liebigs Annalen der Chemie, 1987, p. 29 - 37
[3] Chemical Communications, 2018, vol. 54, # 15, p. 1869 - 1872
[4] Journal of Medicinal Chemistry, 1980, vol. 23, # 12, p. 1358 - 1363
[5] Patent: CN107445892, 2017, A. Location in patent: Paragraph 0016

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Suppliers

Americas 1 Belgium 1 Canada 1 China 130 Europe 3 Germany 4 India 13 Japan 3 Russia 1 Switzerland 1 The Netherlands 1 United Kingdom 10 United States 28 Global 197

J & K SCIENTIFIC LTD.

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View Lastest Price from 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid 68077-26-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-02

Shaanxi Dideu New Materials Co. Ltd

Product: 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 68077-26-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-21

Career Henan Chemical Co

Product: 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 68077-26-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-20

68077-26-9, 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

Norfloxacin Norfloxacin Impurity 2 6-Chloro-1-Ethyl-4-Oxo-7-(Piperazin-1-yl)-1,4-Dihydroquinoline-3-Carboxylic acid Desethylene Norfloxacin Hydrochloride Norfloxacin EP Impurity E Norfloxacin EP Impurity H 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid Norfloxacin EP Impurity D Norfloxacin EP Impurity G Norfloxacin EP Impurity C 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 3-Quinolinecarboxylic acid 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER METHYL 7-CHLORO-6-FLUORO-1-CYCLOPROPYL-1,4-DIHYDROGEN-4-OXO-3-QUINOLINE CARBOXYLATE AKOS 92521 AKOS 1306

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolind-3-carboxylic acid

Norfloxacin EP Impurity A

7-CHLORO-1,4-DIHYDRO-1-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID

7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID

7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO QUINOLINE-3-CARBOXYLIC ACID

7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID

AKOS 1303

1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID

TIMTEC-BB SBB003042

7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid

7-CHLORO-1,4-DIHYDRO-L-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID

7-CHLORO-1-ETHYL-6-FLUORO-4-OXOBYDROQUINOINE-3-CARBOXYLIC ACID

7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID 98%

7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBO

Norfloxacin ImpurityⅠ：Norfloxacin EP Impurity A

7-chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylate

Norfloxacin EP Imp A

1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDNORFLOXACIN

A mixture of: 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 5-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloroquinoline-3-carboxylic acid

7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

A mixture of: 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and 5-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

7-Chloro-1-ethyl-6-fluoro-4-oxohydroquinoline-3-carboxylic acid,98%

1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-3-quinolinecarboxylic Acid

Norfloxacin Q-Acid

7-CHLORO-6-FLUORO-1-ETHYL-4-OXOQUINOLINE-3-CARBOXYLIC ACID

NORF-007

Norfloxacin Impurity 1(Norfloxacin EP Impurity A)

3-Quinolinecarboxylicacid, 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-

Norfloxacin impurity A CRS

7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4

7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid &gt

Norfloxacin Related Compound A (15 mg)

Norfloxacin EP Impurity A/ Norfloxacin Related Compound A

TIANFU-CHEM CAS:68077-26-9 1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Norfloxacin Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic a (1471517)

Norfloxacin USP Related Compound A

6-chloro-1-ethyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Pefloxacin Mesilate Dihydrate Impurity F

Pefloxacin Mesilate Dihydrate EP Impurity F

Norfloxacin Impurity 11

Norfloxacin ImpurityⅠ

Norfloxacincarboxylicacid

Norfloxacin ImpurityⅠ：Norfloxacin EP Impurity A

68077-26-9

8077-26-9

C12H9ClFNO3

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals