4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- Product Name
- 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- CAS No.
- 13721-01-2
- Chemical Name
- 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- Synonyms
- AURORA 17733;TIMTEC-BB SBB000272;VX770-INTERMEDIATES;Ivacaftor impurities11;IvacaftorIntermediateB;4-Quinolone-3-carboxylic acid;4-Quinolone-3-carboxylic acid-D4;4-oxo-1H-quinoline-3-carboxylic acid;1,2-Dihydro-4-oxo-quinoline-3-carboxyl;4-Oxo-1,4-dihydroquinoline-3-carboxylic
- CBNumber
- CB4196556
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 13721-01-2.mol
4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID Property
- Melting point:
- 269-270℃
- Boiling point:
- 358℃
- Density
- 1.429
- Flash point:
- 171℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 0.80±0.20(Predicted)
- form
- Solid
- color
- Off-White to Light Yellow
- λmax
- 310nm(DMSO)(lit.)
- InChI
- InChI=1S/C10H7NO3/c12-9-6-3-1-2-4-8(6)11-5-7(9)10(13)14/h1-5H,(H,11,12)(H,13,14)
- InChIKey
- ILNJBIQQAIIMEY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(=O)C(C(O)=O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4881
- Product name
- 1,4-Dihydro-4-oxoquinoline-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- D4881
- Product name
- 1,4-Dihydro-4-oxoquinoline-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- O855400
- Product name
- 4-Oxo-1,4-dihydroquinolineCarboxylicAcid
- Packaging
- 50g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- 020266
- Product name
- 4-Oxo-1,4-dihydroquinoline-3-carboxylic acid
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- CS-M2264
- Product name
- 3-Quinolinecarboxylicacid,1,4-dihydro-4-oxo-
- Purity
- ≥97.0%
- Packaging
- 10g
- Price
- $56
- Updated
- 2021/12/16
4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-Oxo-1,4-dihydroquinoline Carboxylic Acid is a novel HIV-1 integrase strand transfer inhibitor.
Synthesis
26892-90-0
13721-01-2
General procedure for the synthesis of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid from ethyl 4-hydroxyquinoline-3-carboxylate: ethyl 4-hydroxyquinoline-3-carboxylate (15 g, 69 mmol) was suspended in 2N sodium hydroxide solution (150 mL), and the reaction was stirred under refluxing conditions for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble material. The filtrate was acidified to pH 4 with 2N hydrochloric acid and a white precipitate was precipitated. The precipitate was collected by filtration, washed several times with deionized water and finally dried under vacuum to afford 4-oxo-1,4-dihydroquinoline-3-carboxylic acid as a light white solid (10.5 g, 92% yield). The product was characterized by 1H NMR (DMSO-d6): δ 15.34 (s, 1H), 13.42 (s, 1H), 8.89 (s, 1H), 8.28 (d, J=8.0 Hz, 1H), 7.88 (m, 1H), 7.81 (d, J=8.4 Hz, 1H), 7.60 (m, 1H).
References
[1] Patent: US2008/90864, 2008, A1. Location in patent: Page/Page column 7
[2] Patent: WO2007/79139, 2007, A2. Location in patent: Page/Page column 46; 47
[3] Patent: US2012/309758, 2012, A1. Location in patent: Page/Page column 61
[4] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0352
[5] Patent: WO2018/64632, 2018, A1. Location in patent: Paragraph 00215; 00216
4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID manufacturers
- Product
- 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 13721-01-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 13721-01-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-14
- Product
- 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID 13721-01-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11