8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate

Product Name: 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
CAS No.: 264622-58-4
Chemical Name: 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
Synonyms: MRS 1754 hydrate;MRS 1754, 10 mM in DMSO;MRS 1754, A2B antagonist;MRS1754;MRS-1754;MRS 1754;Adenosine Receptor,MRS-1754,Inhibitor,MRS 1754,P1 receptor,MRS1754,inhibit;N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide;8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate;N-(4-Cyanophenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide;N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetaMide;AcetaMide,N-(4-cyanophenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-
CBNumber: CB62098696
Molecular Formula: C26H26N6O4
Formula Weight: 486.52
MOL File: 264622-58-4.mol

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8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble >10mg/mL
pka: 8.24±0.70(Predicted)
form: solid
color: off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6316
Product name: MRS 1754 hydrate
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $265
Updated: 2024/03/01

Sigma-Aldrich

Product number: M6316
Product name: MRS 1754 hydrate
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $837
Updated: 2024/03/01

TRC

Product number: M750243
Product name: MRS1754
Packaging: 1mg
Price: $115
Updated: 2021/12/16

ChemScene

Product number: CS-0003210
Product name: MRS1754
Purity: 98.31%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0003210
Product name: MRS1754
Purity: 98.31%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

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8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Chemical Properties,Usage,Production

Uses

MRS 1754 acts as an adenosine receptor antagonist which displays bronchospasmolytic activity, applicable to treatments involving respiratory disorders.

Definition

ChEBI: N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide is an oxopurine.

Biological Activity

Selective adenosine A 2B receptor antagonist (K i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA 2B , rA 1 , hA 1 , hA 2A , hA 3 and rA 2A receptors respectively).

Biochem/physiol Actions

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.

storage

Desiccate at RT

8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Suppliers

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264622-58-4, 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrateRelated Search:

1,3-DIETHYL-8-PHENYLXANTHINE 1,3-DIPROPYL-8-PHENYLXANTHINE 8-PHENYLTHEOPHYLLINE 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate

8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate

MRS 1754 hydrate

MRS1754;MRS-1754;MRS 1754

AcetaMide, N-(4-cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-

N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetaMide

AcetaMide,N-(4-cyanophenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-

N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide

N-(4-Cyanophenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide

Adenosine Receptor,MRS-1754,Inhibitor,MRS 1754,P1 receptor,MRS1754,inhibit

MRS 1754, A2B antagonist

MRS 1754, 10 mM in DMSO

264622-58-4