6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID

Product Name: 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
CAS No.: 33458-93-4
Chemical Name: 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID
Synonyms: AH 6809;AH6809;AH-6809;6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID;6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID;6-Isopropoxy-9-oxo-9H-xanthene-2-carboxylic acid;6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid;9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid;9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo-;Prostaglandin Receptor,AH-6809,inhibit,Inhibitor,AH6809,AH 6809
CBNumber: CB6209962
Molecular Formula: C17H14O5
Formula Weight: 298.29
MOL File: 33458-93-4.mol

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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Property

storage temp.: Sealed in dry,Room Temperature
solubility: ethanol: 2.5 mg/mL, soluble
form: crystalline solid or supercooled liquid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1221
Product name: AH6809
Purity: ≥98%, crystalline solid or supercooled liquid
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 14050
Product name: AH 6809
Purity: ≥98%
Packaging: 1mg
Price: $19
Updated: 2024/03/01

Cayman Chemical

Product number: 14050
Product name: AH 6809
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 14050
Product name: AH 6809
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 14050
Product name: AH 6809
Purity: ≥98%
Packaging: 50mg
Price: $595
Updated: 2024/03/01

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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Description

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP₁, EP₂, EP₃-III, and DP₁ receptors. AH 6809 blocks the PGE₂-induced accumulation of cAMP in COS cells transfected with the human EP₂ receptor. It also blocks the accumulation of Ca²⁺ in Xenopus oocytes expressing the human EP₁ receptor. In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent. In the mouse, AH 6809 has the highest affinity for the EP₂ receptor, but also acts as a weak ligand at the murine EP₁ and DP₁ receptors. In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD₂, but not PGI₂, with an EC₅₀ of about 5 x 10⁻⁵ M.

Uses

AH-6809 is a prostaglandin E2 receptor antagonist.

Definition

ChEBI: 9-oxo-6-propan-2-yloxy-2-xanthenecarboxylic acid is a member of xanthones.

Biological Activity

Antagonist at prostaglandin EP 1 (pA 2 = 6.8 ) and EP 2 (K i = 350 nM) receptors. Also weakly inhibits DP receptors (pA 2 = 4.45).

storage

Store at RT

References

1) Coleman in Prostaglandins and Related Substances: A Practical Approach; ILR Press, Oxford and Washington D.C. 1987, pg 267

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Suppliers

China 64 Germany 2 Switzerland 3 United Kingdom 2 United States 16 Global 87

3B Pharmachem (Wuhan) International Co.,Ltd.

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TargetMol Chemicals Inc.

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33458-93-4, 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACIDRelated Search:

METYRAPONE Lovastatin URB597 NAGLY Titanium diisopropoxide bis(acetylacetonate) Aluminium isopropoxide Oxygen-fluorine acid Xanthone 4-(3-HYDROXYPHENOXY)BENZOIC ACID 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID 3-acetyl-4-hydroxybenzoic acid 4-(3-METHOXY-PHENOXY)-BENZALDEHYDE

6-ISOPROPOXY-9-OXOXANTHENE-2-CARBOXYLIC ACID

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID

AH 6809

6-(1-Methylethoxy)-9-oxo-9H-xanthene-2-carboxylic acid

6-Isopropoxy-9-oxo-9H-xanthene-2-carboxylic acid

AH6809;AH-6809

9H-Xanthene-2-carboxylic acid, 6-(1-methylethoxy)-9-oxo-

Prostaglandin Receptor,AH-6809,inhibit,Inhibitor,AH6809,AH 6809

9-oxo-6-(propan-2-yloxy)-9H-xanthene-2-carboxylic acid

33458-93-4