1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE

Product Name: 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE
CAS No.: 99010-24-9
Chemical Name: 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE
Synonyms: DesaMino IMiquiMod;Imiquimod USP RC A;Imiquimod Impurity-A;IMiquiMod Related CoMpound A;Imiquimod USP Related Compound A;Imiquimod USP related Substance A;1-Isobutyl-1H-imidazo[4,5-c]quinoli;1-ISOBUTYL-1H-IMIDAZO[4,5-C]QUINOLINE;1-(2-methylpropyl)imidazo[4,5-c]quinoline;1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE
CBNumber: CB6213635
Molecular Formula: C14H15N3
Formula Weight: 225.29
MOL File: 99010-24-9.mol

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1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Property

Melting point:: 92-95℃
Boiling point:: 402.6±37.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 5.34±0.30(Predicted)
Appearance: Off-white to gray Solid
CAS DataBase Reference: 99010-24-9(CAS DataBase Reference)

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Safety

HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1338324
Product name: Imiquimod Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25MG
Price: $1300
Updated: 2025/07/31

TRC

Product number: D288315
Product name: DesaminoImiquimod
Packaging: 25mg
Price: $265
Updated: 2021/12/16

TRC

Product number: D288315
Product name: DesaminoImiquimod
Packaging: 10mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 6934AC
Product name: 1-Isobutyl-1H-imidazo[4,5-c]quinoline
Packaging: 250mg
Price: $208
Updated: 2021/12/16

AK Scientific

Product number: 6934AC
Product name: 1-Isobutyl-1H-imidazo[4,5-c]quinoline
Packaging: 1g
Price: $424
Updated: 2021/12/16

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1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Chemical Properties,Usage,Production

Uses

Desamino Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.

Synthesis

99010-09-0

64-18-6

99010-24-9

Example 1 Preparation of 1-isobutyl-1H-imidazo[4,5-c]quinoline (II): 3-amino-4-isobutylaminoquinoline (215 g, 1.0 mol) was dissolved in formic acid (1000 ml), and the reaction mixture was heated to reflux at 110-115°C. The reflux reaction was maintained for 8-10 hours. Upon completion of the reaction, the excess formic acid was removed by distillation under reduced pressure and the residue was diluted with 3.5 liters of water. Subsequently, the pH was adjusted to 10-11 with 30% sodium hydroxide solution at 20 °C. The reaction mixture was cooled to 100 °C and stirring was continued for 3 h. The solid product was precipitated. The solid was collected by filtration, washed with water and dried to give 1-isobutyl-1H-imidazo[4,5-c]quinoline (221 g, 98% yield) as a white solid. Melting point: 91-94°C. Mass spectrum (m/z): M+ 226. 1H NMR (200 MHz, DMSO-d6): δ-value see attached.

References

[1] Patent: WO2006/70379, 2006, A1. Location in patent: Page/Page column 8
[2] Patent: WO2006/70408, 2006, A2. Location in patent: Page/Page column 7; 11
[3] Patent: US6348462, 2002, B1. Location in patent: Page column 22
[4] Patent: WO2014/120995, 2014, A2. Location in patent: Page/Page column 174-175

1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Suppliers

China 72 India 4 Ukraine 1 United Kingdom 2 United States 12 Global 91

J & K SCIENTIFIC LTD.

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View Lastest Price from 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE manufacturers

Career Henan Chemical Co

Product: 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE 99010-24-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-03-05

99010-24-9, 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINERelated Search:

Imiquimod Impurity 2 4-amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol [99010-09-0], C13H17N3,215.30 Imiquimod Impurity 6 N4-(2-METHYLPROPYL)-3,4-QUINOLINEDIAMINE Imiquimod Related Compound B (25 mg) (1-Isobutyl-1H-imidazo[4,5-c]quinoline 5-oxide) Imiquimod Related Compound D (25 mg) (1-Propyl-1H-imidazo[4,5-c]quinolin-4-amine) Imiquimod Impurity 5 4-CHLORO-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE Imiquimod IMIQUIMOD ACETATE RESIQUIMOD IMIQUIMOD, [3H]- 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE 4-CHLORO-1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE 98%MIN

1H-IMIDAZO[4,5-C]QUINOLINE, 1-(2-METHYLPROPYL)-

1-ISOBUTYL-1H-IMIDAZO[4,5-C]QUINOLINE

1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE

Imiquimod Related Compound A (25 mg) (1-Isobutyl-1H-imidazo[4,5-c]quinoline)

IMiquiMod Related CoMpound A

DesaMino IMiquiMod

1-(2-methylpropyl)imidazo[4,5-c]quinoline

1-Isobutyl-1H-imidazo[4,5-c]quinoli

Imiquimod USP RC A

Imiquimod Impurity 1 (Imiquimod Related Compound A)

Imiquimod Impurity-A

Imiquimod Related Compound A (1-Isobutyl-1H-imidazo[4,5-c]quinoline) (1338324)

Imiquimod USP Related Compound A

Imiquimod USP related Substance A

1-Isobutyl-1H-imidazo[4,5-c]quinoline (Desaminoimiquimod)

99010-24-9