N,N'-Bis(phenylmethyl)-1,2-ethanediamine Property

Melting point:

23-25°C

Boiling point:

195 °C4 mm Hg(lit.)

Density 

1.02 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.565(lit.)

Flash point:

>230 °F

storage temp. 

Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Water (Slightly)

form 

Solid

pka

9.15±0.19(Predicted)

Specific Gravity

1.025

color 

White to Off-White

Water Solubility 

Slightly soluble in water.

FreezingPoint 

21.0 to 25.0 ℃

Sensitive 

Air Sensitive

Merck 

14,1064

BRN 

786668

CAS DataBase Reference

140-28-3(CAS DataBase Reference)

NIST Chemistry Reference

1,2-Ethanediamine, N,N'-bis(phenylmethyl)-(140-28-3)

EPA Substance Registry System

1,2-Ethanediamine, N,N'-bis(phenylmethyl)- (140-28-3)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

RIDADR 

2927

WGK Germany 

3

RTECS 

KV3325000

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29215990

Toxicity

LD50 orl-mus: 388 mg/kg CNCRA6 52,579,68

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N,N'-Bis(phenylmethyl)-1,2-ethanediamine Chemical Properties,Usage,Production

Chemical Properties

light yellow liquid

Uses

N,N'-Dibenzylethylenediamine is an intermediate of cephalosporin and penicillin.

Definition

ChEBI: Benzathine is a diamine. It is a conjugate base of a benzathine(1+).

Synthesis Reference(s)

The Journal of Organic Chemistry, 55, p. 3209, 1990 DOI: 10.1021/jo00297a042

Safety Profile

Poison by ingestion,intraperitoneal, and parenteral routes. When heated todecomposition it emits toxic vapors of NOx.

Purification Methods

Dissolve DBED in acid, extract with toluene, basify, extract it with Et2O, dry over solid KOH, evaporate and fractionate it in vacuo. The diacetate crystallises from H2O by addition of EtOH and has m 111o (solubility in H2O is ~25%). The dihydrochloride has m 306-308o (from H2O) and the dipicrate has m 212o(dec) (from H2O). [Frost et al., J Am Chem Soc 71 3842 1949, Beilstein 12 H 1067, 12 III 2304.]