3-Acetyl-2-oxazolidinone Property

Melting point:

69-71 °C(lit.)

Boiling point:

110-114 °C2 mm Hg(lit.)

Density 

1.3816 (rough estimate)

refractive index 

1.4220 (estimate)

Safety

WGK Germany 

3

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

3-Acetyl-2-oxazolidinone Chemical Properties,Usage,Production

Uses

3-Acetyl-2-oxazolidinone is used as a reagent in the enantioselective synthesis of (+)-7-epigoniodiol, (-)-8-epigoniodiol, and (+)-9-deoxygoniopypyrone. Also a useful synthetic intermediate in the synthesis of 2-Oxazolone (O846555) which is a versatile tool for synthetic organic chemist.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 7, p. 4, 1990
The Journal of Organic Chemistry, 51, p. 2977, 1986 DOI: 10.1021/jo00365a024