5-Bromo-4-chloro-2,6-dimethylpyrimidine

5-Bromo-4-chloro-2,6-dimethylpyrimidine Property

Melting point:

45 °C

Boiling point:

264.9±35.0 °C(Predicted)

Density 

1.621±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-0.23±0.39(Predicted)

Appearance

White to off-white Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

5-Bromo-4-chloro-2,6-dimethylpyrimidine Chemical Properties,Usage,Production

Synthesis

(b) Synthesis of 5-bromo-4-chloro-2,6-dimethylpyrimidine. 5-Bromo-2,6-dimethylpyrimidin-4-ol (3.95 g, 19.45 mmol) was mixed with phosphorochloridic acid (6 mL, 64.4 mmol) and heated to reflux for 3 h at 110 °C. The reaction was carried out at a pressure of 1.5 °F. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure, followed by the slow and careful addition of ice water to precipitate a white precipitate. The solid was collected by filtration, washed thoroughly with cold water and dried to afford the target product 5-bromo-4-chloro-2,6-dimethylpyrimidine (2.73 g, 63% yield). The product was analyzed by LCMS (ES+), m/e 221 [M+H]+.

References

[1] Patent: WO2013/96151, 2013, A1. Location in patent: Page/Page column 131
[2] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0346; 0348
[3] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00202
[4] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00160