ChemicalBook > CAS DataBase List > 4-CHLORO-2,6-DIMETHYLPYRIMIDINE

4-CHLORO-2,6-DIMETHYLPYRIMIDINE

Product Name
4-CHLORO-2,6-DIMETHYLPYRIMIDINE
CAS No.
4472-45-1
Chemical Name
4-CHLORO-2,6-DIMETHYLPYRIMIDINE
Synonyms
Albb-005431;ASISCHEM A63094;TIMTEC-BB SBB010291;6-Chloro-2,4-dimethylpyrimidine;2,4-Dimethyl-6-chloropyrimidine;4-CHLORO-2,6-DIMETHYLPYRIMIDINE;Pyrimidine, 4-chloro-2,6-dimethyl-;4-Chloro-2,6-dimethylpyrimidine95%;4-CHLORO-2,6-DIMETHYLPYRIMIDINE 95%;4-Chloro-2,6-dimethylpyrimidine,97%
CBNumber
CB2489784
Molecular Formula
C6H7ClN2
Formula Weight
142.59
MOL File
4472-45-1.mol
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4-CHLORO-2,6-DIMETHYLPYRIMIDINE Property

Melting point:
39-40 °C
Boiling point:
180 °C
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
liquid
pka
1.19±0.30(Predicted)
color 
Clear, colourless
CAS DataBase Reference
4472-45-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C584950
Product name
4-Chloro-2,6-dimethylpyrimidine
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR55150
Product name
4-Chloro-2,6-dimethylpyrimidine
Purity
99%
Packaging
1g
Price
$22
Updated
2021/12/16
Matrix Scientific
Product number
018781
Product name
4-Chloro-2,6-dimethyl-pyrimidine
Packaging
500mg
Price
$24
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-AE
Product name
4-Chloro-2,6-dimethylpyrimidine
Packaging
1g
Price
$24
Updated
2021/12/16
Matrix Scientific
Product number
018781
Product name
4-Chloro-2,6-dimethyl-pyrimidine
Packaging
1g
Price
$39
Updated
2021/12/16
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4-CHLORO-2,6-DIMETHYLPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

6622-92-0

4472-45-1

General procedure for the synthesis of 4-chloro-2,6-dimethylpyrimidines from 2,4-dimethyl-6-hydroxypyrimidines: phosphorous trichloride (POCl3, 0.460 g, 3.0 mmol) was added to a solution of 2,4-dimethyl-6-hydroxypyrimidines (1.0 mmol) in toluene (15 mL), and the mixture was stirred for 3 hours under reflux conditions. Upon completion of the reaction, excess phosphorous trichloride was removed by distillation under reduced pressure and the reaction was subsequently quenched by the addition of ice water (10 mL). The pH of the reaction mixture was adjusted to 9-10 with sodium carbonate solution and then extracted with methyl tert-butyl ether (MTBE). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to afford the target product 4-chloro-2,6-dimethylpyrimidine (yield: 82%). Mass spectrometry (ESI) showed a molecular ion peak (m/z) [M + H]+ of 143.1.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 10, p. 1769 - 1775
[2] Tetrahedron Letters, 1999, vol. 40, # 42, p. 7477 - 7478
[3] Patent: US5438058, 1995, A
[4] Patent: US6093718, 2000, A

4-CHLORO-2,6-DIMETHYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

DIETHYL PYRIMIDINE-4,6-DICARBOXYLATE DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE PYRIMIDINE-4,6-DICARBOXYLIC ACID
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4-CHLORO-2,6-DIMETHYLPYRIMIDINE Suppliers

China 135 Europe 1 France 1 Germany 1 India 5 Russia 1 The Netherlands 1 Ukraine 1 United Kingdom 8 United States 25 Global 179
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
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10186
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62
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
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China
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42934
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Shanghai Ennopharm Co., Ltd.
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+86 (21) 6435-5022
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China
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Record Tech (Shanghai) Co., LTD
Tel
13761627472
Fax
86-21-64965863
Email
183009664@qq.com
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China
ProdList
649
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China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
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Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
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View Lastest Price from 4-CHLORO-2,6-DIMETHYLPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
4-CHLORO-2,6-DIMETHYLPYRIMIDINE 4472-45-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-06
Career Henan Chemical Co
Product
4-CHLORO-2,6-DIMETHYLPYRIMIDINE 4472-45-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

4472-45-1, 4-CHLORO-2,6-DIMETHYLPYRIMIDINERelated Search:

Pyrimidine 5-Chloro-2,6-dimethylpyrimidine 2-CHLORO-4,6-DIMETHYLPYRIMIDINE,98.0+%(GC),2-CHLORO-4,6-DIMETHYLPYRIMIDINE 5-Bromo-4-chloro-2,6-dimethylpyrimidine 2-Amino-5-chloro-4,6-dimethylpyrimidine,5-Chloro-4,6-dimethylpyrimidine-2-amine 4-AMINO-2-CHLORO-6,7-DIMETHYLPYRIMIDINE,4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE 4-Chloro-5-chloro-2,6-dimethylpyrimidine 5-Bromo-2-chloro-4,6-dimethylpyrimidine 6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,6-1H,3H-DIONE,6-Chloro-1,3-dimethylpyrimidine-2,4-dione,6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE 4-chloro-2,5-dimethylpyrimidine 4-CHLORO-5,6-DIMETHYLPYRIMIDINE ETHYL 6-CHLORO-2,5-DIMETHYLPYRIMIDINE-4-CARBOXYLATE

  • 4-CHLORO-2,6-DIMETHYLPYRIMIDINE
  • TIMTEC-BB SBB010291
  • Pyrimidine, 4-chloro-2,6-dimethyl- (7CI,8CI,9CI)
  • 4-Chloro-2,6-dimethylpyrimidine95%
  • ASISCHEM A63094
  • 4-CHLORO-2,6-DIMETHYLPYRIMIDINE 95%
  • Albb-005431
  • 2,4-Dimethyl-6-chloropyrimidine
  • 6-Chloro-2,4-dimethylpyrimidine
  • D241 4-Chloro-2,6-dimethyl-pyrimidine
  • Pyrimidine, 4-chloro-2,6-dimethyl-
  • 4-Chloro-2,6-dimethylpyrimidine,97%
  • 4-CHLORO-2,6-DIMETHYLPYRIMIDINE ISO 9001：2015 REACH
  • 4472-45-1
  • Heterocycle-Pyrimidine series
  • alkyl chloride
  • API intermediates
  • PYRIMIDINE