4-CHLORO-2,6-DIMETHYLPYRIMIDINE
- Product Name
- 4-CHLORO-2,6-DIMETHYLPYRIMIDINE
- CAS No.
- 4472-45-1
- Chemical Name
- 4-CHLORO-2,6-DIMETHYLPYRIMIDINE
- Synonyms
- Albb-005431;ASISCHEM A63094;TIMTEC-BB SBB010291;6-Chloro-2,4-dimethylpyrimidine;2,4-Dimethyl-6-chloropyrimidine;4-CHLORO-2,6-DIMETHYLPYRIMIDINE;Pyrimidine, 4-chloro-2,6-dimethyl-;4-Chloro-2,6-dimethylpyrimidine95%;4-CHLORO-2,6-DIMETHYLPYRIMIDINE 95%;4-Chloro-2,6-dimethylpyrimidine,97%
- CBNumber
- CB2489784
- Molecular Formula
- C6H7ClN2
- Formula Weight
- 142.59
- MOL File
- 4472-45-1.mol
4-CHLORO-2,6-DIMETHYLPYRIMIDINE Property
- Melting point:
- 39-40 °C
- Boiling point:
- 180 °C
- Density
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- 1.19±0.30(Predicted)
- color
- Clear, colourless
- CAS DataBase Reference
- 4472-45-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C584950
- Product name
- 4-Chloro-2,6-dimethylpyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR55150
- Product name
- 4-Chloro-2,6-dimethylpyrimidine
- Purity
- 99%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 018781
- Product name
- 4-Chloro-2,6-dimethyl-pyrimidine
- Packaging
- 500mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 3H32-5-AE
- Product name
- 4-Chloro-2,6-dimethylpyrimidine
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 018781
- Product name
- 4-Chloro-2,6-dimethyl-pyrimidine
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
4-CHLORO-2,6-DIMETHYLPYRIMIDINE Chemical Properties,Usage,Production
Synthesis
6622-92-0
4472-45-1
General procedure for the synthesis of 4-chloro-2,6-dimethylpyrimidines from 2,4-dimethyl-6-hydroxypyrimidines: phosphorous trichloride (POCl3, 0.460 g, 3.0 mmol) was added to a solution of 2,4-dimethyl-6-hydroxypyrimidines (1.0 mmol) in toluene (15 mL), and the mixture was stirred for 3 hours under reflux conditions. Upon completion of the reaction, excess phosphorous trichloride was removed by distillation under reduced pressure and the reaction was subsequently quenched by the addition of ice water (10 mL). The pH of the reaction mixture was adjusted to 9-10 with sodium carbonate solution and then extracted with methyl tert-butyl ether (MTBE). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to afford the target product 4-chloro-2,6-dimethylpyrimidine (yield: 82%). Mass spectrometry (ESI) showed a molecular ion peak (m/z) [M + H]+ of 143.1.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 10, p. 1769 - 1775
[2] Tetrahedron Letters, 1999, vol. 40, # 42, p. 7477 - 7478
[3] Patent: US5438058, 1995, A
[4] Patent: US6093718, 2000, A
4-CHLORO-2,6-DIMETHYLPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-2,6-DIMETHYLPYRIMIDINE Suppliers
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- enamine@enamine.net
- Country
- Ukraine
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View Lastest Price from 4-CHLORO-2,6-DIMETHYLPYRIMIDINE manufacturers
- Product
- 4-CHLORO-2,6-DIMETHYLPYRIMIDINE 4472-45-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 4-CHLORO-2,6-DIMETHYLPYRIMIDINE 4472-45-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24