DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE
- Product Name
- DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE
- CAS No.
- 6345-43-3
- Chemical Name
- DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE
- Synonyms
- DiMethyl 4,6-pyriMidinedicarboxylate;DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE;4,6-dimethyl pyrimidine-4,6-dicarboxylate;PYRIMIDINE-4,6-DICARBOXYLIC ACID DIMETHYL ESTER;4,6-PyriMidinedicarboxylic acid, 4,6-diMethyl ester;DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB4310215
- Molecular Formula
- C8H8N2O4
- Formula Weight
- 196.16
- MOL File
- 6345-43-3.mol
DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Property
- Melting point:
- 78-79°C
- Boiling point:
- 305.7±22.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.53±0.17(Predicted)
- Appearance
- White to off-white Solid
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D480285
- Product name
- Dimethyl4,6-Pyrimidinedicarboxylate
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- D480285
- Product name
- Dimethyl4,6-Pyrimidinedicarboxylate
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 4H58-1-UW
- Product name
- 4,6-Dimethyl pyrimidine-4,6-dicarboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 4H58-1-UW
- Product name
- 4,6-Dimethyl pyrimidine-4,6-dicarboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 9680AB
- Product name
- Dimethylpyrimidine-4,6-dicarboxylate
- Packaging
- 5g
- Price
- $517
- Updated
- 2021/12/16
DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Chemical Properties,Usage,Production
Uses
Dimethyl 4,6-Pyrimidinedicarboxylate is a compound involved in the preparation of radiolabeled selective matrix metalloproteinase 13 (MMP-13) inhibitors.
Synthesis
67-56-1
16490-02-1
6345-43-3
The general procedure for the synthesis of dimethyl pyrimidine-4,6-dicarboxylate from methanol and pyrimidine-4,6-dicarboxylic acid was as follows: 10 g (0.059 mol) of pyrimidine-4,6-dicarboxylic acid was suspended in 1.4 L of methanol, followed by the addition of 10.93 mL (0.356 mol) of concentrated hydrochloric acid. The reaction mixture was stirred at reflux for 3 hours at 65 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was redissolved in methanol. After filtration of the mixture, the filtrate was concentrated to afford the product dimethyl pyrimidine-4,6-dicarboxylate in a yield of 11.02 g (94.4% yield). Mass spectrometry (ES+) analysis showed m/e = 197.20.
References
[1] Patent: US2003/229103, 2003, A1. Location in patent: Page 9
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7053 - 7056
[3] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 77
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 307 - 321
DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE manufacturers
- Product
- DiMethyl pyrimidine-4,6-dicarboxylate 6345-43-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12