4,6-PYRIMIDINE DICARBOXYLIC ACID

Product Name: 4,6-PYRIMIDINE DICARBOXYLIC ACID
CAS No.: 16490-02-1
Chemical Name: 4,6-PYRIMIDINE DICARBOXYLIC ACID
Synonyms: NSC 44347;6-PYRIMIDINE DICARBOXYLIC ACID;4,6-PYRIMIDINE DICARBOXYLIC ACID;4,6-PYRIMIDINE DICARBOXYLIC ACID,6-NITROQUINAZOLIN-4(3H)-ONE
CBNumber: CB51482534
Molecular Formula: C6H4N2O4
Formula Weight: 168.11
MOL File: 16490-02-1.mol

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4,6-PYRIMIDINE DICARBOXYLIC ACID Property

Melting point:: 238-240℃
Boiling point:: 497.4±30.0 °C(Predicted)
Density: 1.665±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.14±0.10(Predicted)
form: solid
color: White

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P997340
Product name: 4,6-PyrimidinedicarboxylicAcid
Packaging: 10g
Price: $415
Updated: 2021/12/16

TRC

Product number: P997340
Product name: 4,6-PyrimidinedicarboxylicAcid
Packaging: 25g
Price: $965
Updated: 2021/12/16

Apolloscientific

Product number: OR55279
Product name: Pyrimidine-4,6-dicarboxylicacid
Packaging: 10g
Price: $247
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-1-1R
Product name: Pyrimidine-4,6-dicarboxylic acid
Packaging: 10g
Price: $272
Updated: 2021/12/16

AK Scientific

Product number: Z3392
Product name: Pyrimidine-4,6-dicarboxylicacid
Packaging: 25g
Price: $335
Updated: 2021/12/16

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4,6-PYRIMIDINE DICARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

4,6-Pyrimidinedicarboxylic Acid is used in the preparation of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases.

Synthesis

6345-43-3

16490-02-1

General procedure for the synthesis of pyrimidine-4,6-dicarboxylic acid from dimethyl pyrimidine-4,6-dicarboxylate: To a solution of dimethyl pyrimidine-4,6-dicarboxylate (170 mg, 0.87 mmol) in methanol (5 mL) was added 1 N sodium hydroxide solution (5 mL, 5.00 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting concentrated solution was acidified to pH 2-3 with 5 N hydrochloric acid.The resulting white precipitate was collected by filtration and washed with distilled water (2 mL) to give the final pyrimidine-4,6-dicarboxylic acid (125 mg, 86% yield).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7053 - 7056
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 77

4,6-PYRIMIDINE DICARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-PYRIMIDINE DICARBOXYLIC ACID Suppliers

China 87 India 3 United Kingdom 1 United States 8 Global 99

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View Lastest Price from 4,6-PYRIMIDINE DICARBOXYLIC ACID manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4,6-PYRIMIDINE DICARBOXYLIC ACID 16490-02-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-11-04

Career Henan Chemical Co

Product: 4,6-PYRIMIDINE DICARBOXYLIC ACID 16490-02-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

16490-02-1, 4,6-PYRIMIDINE DICARBOXYLIC ACIDRelated Search:

DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE PyriMidine-5-carboxaMidine hydrochloride 5-AMINOPYRIMIDINE Pyrimidine-2-sulfonic acid pentafluorophenyl ester 4-Pyrimidinecarbonitrile (7CI,9CI) PYRIMIDINE-5-CARBOTHIOIC ACID AMIDE PYRIMIDINE-4-CARBOXYLIC ACID HYDRAZIDE Pyrimidine-5-carboxaldehyde Pyrimidine-2-carboxylic acid PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER Pyrimidine-5-boronic acid pinacol ester 5-PYRIMIDINECARBOXAMIDE 4-Pyrimidinecarboxylic acid PYRIMIDIN-4-YL-METHANOL 4,6-DIMETHYLPYRIMIDINE PYRIMIDINE-4-CARBOXALDEHYDE 4,6-PYRIMIDINE DICARBOXYLIC ACID

4,6-PYRIMIDINE DICARBOXYLIC ACID

NSC 44347

6-PYRIMIDINE DICARBOXYLIC ACID

4,6-PYRIMIDINE DICARBOXYLIC ACID,6-NITROQUINAZOLIN-4(3H)-ONE

16490-02-1