6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione

Product Name: 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
CAS No.: 6972-27-6
Chemical Name: 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
Synonyms: 6-CHLORO-1,3-DIMETHYLURACIL;6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;4-Chlor;AURORA KA-4432;Urapidil Impurity 12;Urapidil Impurity 14;6-Chloro-1,3-dimethyl;4-Chloro-1,3-dimethyluracil;1,3-DIMETHYL-6-CHLOROURACIL;1,3-Dimethyl-4-chlorouracil
CBNumber: CB8216650
Molecular Formula: C6H7ClN2O2
Formula Weight: 174.59
MOL File: 6972-27-6.mol

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6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Property

Melting point:: 109-113 °C
Boiling point:: 224.6±50.0 °C(Predicted)
Density: 1.4926 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: -3.53±0.40(Predicted)
color: Pale Yellow
Water Solubility: soluble
BRN: 144393
InChI: InChI=1S/C6H7ClN2O2/c1-8-4(7)3-5(10)9(2)6(8)11/h3H,1-2H3
InChIKey: VATQPUHLFQHDBD-UHFFFAOYSA-N
SMILES: C1(=O)N(C)C(Cl)=CC(=O)N1C
CAS DataBase Reference: 6972-27-6(CAS DataBase Reference)
NIST Chemistry Reference: 6-Chloro-2,4-dihydroxy-1,3-dimethylpyrimidine(6972-27-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D1619
Product name: 1,3-Dimethyl-6-chlorouracil
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: D1619
Product name: 1,3-Dimethyl-6-chlorouracil
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $178
Updated: 2025/07/31

TRC

Product number: C596040
Product name: 6-Chloro-1,3-dimethyluracil
Packaging: 25g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC05970
Product name: 6-Chloro-1,3-dimethyluracil
Packaging: 100g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR480621
Product name: 6-Chloro-1,3-dimethyluracil
Purity: 98%
Packaging: 25g
Price: $192
Updated: 2021/12/16

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6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Chemical Properties,Usage,Production

Chemical Properties

white to light yellow flakes or powder

Uses

6-Chloro-1,3-dimethyluracil is a nucleobase constitute of nucleic acid. An intermediate for the synthesis of substituted uracils and derivatives.

Synthesis

769-42-6

6972-27-6

1,3-Dimethylbarbituric acid (compound SM1) (7 kg, 44.9 mmol) was used as raw material and dissolved in 120 kg of phosphoryl chloride (POCl3). Water (2.2 kg, 122 mol) was slowly added dropwise to the above solution. After the dropwise addition, the reaction was slowly heated to reflux and maintained for 6 hours; the reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the reaction solution was slowly poured into a large volume of ice water (100 L) and subsequently extracted twice with dichloromethane (50 L) to combine the organic phases. The organic phase was washed with saturated brine (20 L), dried over anhydrous sodium sulfate, filtered and concentrated the organic phase, and finally the yellow solid product 6-chloro-1,3-dimethyluracil (compound SM2) (7.2 kg) was obtained by vacuum drying in 92.3% yield.

References

[1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987, vol. 23, # 6, p. 690 - 697
[2] Khimiya Geterotsiklicheskikh Soedinenii, 1987, vol. 23, # 6, p. 836 - 844
[3] Patent: CN103755705, 2017, B. Location in patent: Paragraph 0033; 0034; 0035
[4] Justus Liebigs Annalen der Chemie, 1958, vol. 612, p. 158,162
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 869 - 871

6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Preparation Products And Raw materials

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Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-05

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Career Henan Chemical Co

Product: 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

6972-27-6, 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedioneRelated Search:

3-[4-(2-methoxyphenyl)-1-piperazinyl]propanenitrile 1-(2-Methoxyphenyl)piperazine 6-[(3-chloropropyl)amino]-1,3-dimethyluracil URAPIDIL 5-METHYL- Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine ZEBULARINE Urapidil Impurity 20 Pseudouridine 2-Demethoxy-4-methoxy urapidil Trelagliptin Impurity 18 alpha-Cyclopentylmandelic acid 2-Bromo-5-fluorotoluene Trelagliptin Impurity 20 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Trelagliptin Impurity Y N-METHYLBARBITURIC ACID 4-Fluoro-2-methylbenzonitrile 2-(Bromomethyl)-6-fluorobenzonitrile

1,3-Dimethyl-4-chlorouracil

2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dimethyl-

1,3-DIMETHYL-6-CHLOROURACIL

AURORA KA-4432

6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE

6-CHLORO-1,3-DIMETHYLURACIL

6-CHLORO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE

6-Chloro-1,3-dimethyl

6-CHLORO-1,3-DIMETHYLURACIL 99%

6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,6-1H,3H-DIONE

4-Chloro-1,3-dimethyluracil

6-Chloro-1,3-dimethylpyrimidine-2,4-dione

1,3-Dimethyl-6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione

6-Chloro-1,3-dimethyluracil,99%

4-Chlor

6-chloro -1,3-two Methyluracil

6-Chloro-1,3-dimethyluracil,97%

6-chloro-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

13-(1-cyclopent-2-enyl)-N-[4-(2-pyridinylsulfamoyl)phenyl]tridecanamide

Tragliptin Starter 1 Impurity 5

1,3-Dimethyl-6-chlorouracil &gt

Urapidil Impurity 12

Urapidil Impurity 14

6-Chloro-1,3-dimethyluracil D3

6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione USP/EP/BP

Alogliptin Benzoate Impurity1640

6972-27-6

C6H7ClN2O2

C6H7N2O2Cl

BioChemical

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides