4-Fluoro-2-methylbenzonitrile
- Product Name
- 4-Fluoro-2-methylbenzonitrile
- CAS No.
- 147754-12-9
- Chemical Name
- 4-Fluoro-2-methylbenzonitrile
- Synonyms
- 4-Fluoro-2-methylben;Alogliptin Impurity 84;Trelagliptin Impurity 58;Methyl-4-fluorobenzonitrile;2-METHYL-4-FLUOROBENZONITRILE;4-FLUORO-2-METHYLBENZONITRILE;2-Methy-4-Fluoro benzonitrile;Benzonitrile, 4-fluoro-2-methyl-;4-Fluoro-2-methylbenzonitrile >4-Fluoro-2-methylbenzonitrile,97%
- CBNumber
- CB4167413
- Molecular Formula
- C8H6FN
- Formula Weight
- 135.14
- MOL File
- 147754-12-9.mol
4-Fluoro-2-methylbenzonitrile Property
- Melting point:
- 70-74 °C (lit.)
- Boiling point:
- 214.6±20.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C8H6FN/c1-6-4-8(9)3-2-7(6)5-10/h2-4H,1H3
- InChIKey
- BJBXUIUJKPOZLV-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(F)C=C1C
- CAS DataBase Reference
- 147754-12-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 594660
- Product name
- 4-Fluoro-2-methylbenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $156
- Updated
- 2023/06/20
- Product number
- F0962
- Product name
- 4-Fluoro-2-methylbenzonitrile
- Purity
- >99.0%(GC)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- F0962
- Product name
- 4-Fluoro-2-methylbenzonitrile
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- F596890
- Product name
- 4-Fluoro-2-methylbenzonitrile
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F596890
- Product name
- 4-Fluoro-2-methylbenzonitrile
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
4-Fluoro-2-methylbenzonitrile Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystalline powder
Uses
As organic intermediate, pharmaceutical intermediate. In chemical synthesis.
Synthesis
80141-91-9
147754-12-9
The general procedure for the synthesis of 4-fluoro-2-methylbenzonitrile from 4-fluoro-2-methylbenzenemethanol was as follows: in a 25 mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-fluoro-2-methylbenzenemethanol (1 mmol) and an aqueous ammonia solution (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature under argon protection for 24 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. Subsequently, the organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the target product 4-fluoro-2-methylbenzonitrile.
References
[1] Organic Letters, 2013, vol. 15, # 8, p. 1850 - 1853
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466
4-Fluoro-2-methylbenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2-methylbenzonitrile manufacturers
- Product
- 4-Fluoro-2-methylbenzonitrile 147754-12-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- 4-Fluoro-2-methylbenzonitrile 147754-12-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 4-Fluoro-2-methylbenzonitrile 147754-12-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10