2-Bromo-5-fluorotoluene

Product Name: 2-Bromo-5-fluorotoluene
CAS No.: 452-63-1
Chemical Name: 2-Bromo-5-fluorotoluene
Synonyms: 1-BROMO-4-FLUORO-2-METHYLBENZENE;2-BROMO-5-FULUOROTOLRENE;2-Bromo-5-fL;2-Bromo-5-fluorotolu;2-Brom-5-fluortoluol;2-Bromo-5-flurotoluene;3-FLUORO-6-BROMOTOLUENE;2-BROMO-5-FLUOROTOLUENE;2-Bromo-5-fuluorotoluene;Trelagliptin Impurity 59
CBNumber: CB2145550
Molecular Formula: C7H6BrF
Formula Weight: 189.02
MOL File: 452-63-1.mol

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2-Bromo-5-fluorotoluene Property

Boiling point:: 177 °C/756 mmHg (lit.)
Density: 1.495 g/mL at 25 °C (lit.)
refractive index: n20/D 1.526(lit.)
Flash point:: 113 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Difficult to mix.
form: clear liquid
color: Colorless to Light yellow to Light orange
Specific Gravity: 1.495
Water Solubility: INSOLUBLE
BRN: 1859121
InChI: InChI=1S/C7H6BrF/c1-5-4-6(9)2-3-7(5)8/h2-4H,1H3
InChIKey: RJPNVPITBYXBNB-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C(F)C=C1C
CAS DataBase Reference: 452-63-1(CAS DataBase Reference)
NIST Chemistry Reference: 2-Bromo-5-fluorotoluene(452-63-1)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36/37/39-37/39
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 365009
Product name: 2-Bromo-5-fluorotoluene
Purity: 98%
Packaging: 25g
Price: $32.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 365009
Product name: 2-Bromo-5-fluorotoluene
Purity: 98%
Packaging: 5g
Price: $28.6
Updated: 2023/01/07

TCI Chemical

Product number: B1303
Product name: 2-Bromo-5-fluorotoluene
Purity: >98.0%(GC)
Packaging: 5g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B1303
Product name: 2-Bromo-5-fluorotoluene
Purity: >98.0%(GC)
Packaging: 25g
Price: $33
Updated: 2025/07/31

TRC

Product number: B693463
Product name: 2-Bromo-5-fluorotoluene
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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2-Bromo-5-fluorotoluene Chemical Properties,Usage,Production

Chemical Properties

colorless to light yellow liqui

Uses

2-Bromo-5-fluorotoluene is used to produce other chemicals. It can produce 2-Bromo-5-fluoro-benzoic acid. The reaction occurs with reagent KMnO4, solvent H2O and other condition of heating.

Synthesis

108-88-3

612-75-9

452-63-1

95-46-5

31543-75-6

General procedure: The general procedure for the synthesis of 3,3'-dimethylbiphenyl, 2-bromo-5-fluorotoluene, 2-bromotoluene, and 2,4-dibromotoluene from toluene was as follows: boron trifluoride (TFB) was synthesized directly according to the literature methodology [7-9] before use. The corresponding aromatics (4 mmol) were dissolved in Freon R 113 (4.1 mL) and the solution was cooled to -25 °C. Under vigorous stirring, the corresponding TFB (2 mmol) was slowly added to the aryl hydrocarbon solution, followed by removal of the cooling bath. The reaction mixture was stirred at 45 °C for 5 hours. Upon completion of the reaction, the reaction mixture was treated with H2O and filtered to remove the metal fluoride precipitate. The liquid phase was treated with 10% NaNO2 aqueous solution to remove trace bromine and 30% CaCl2 aqueous solution to remove F- anions. Freon R 113 was removed from the organic phase by evaporation and the resulting product was purified by rapid chromatography on silica gel, the eluent being a hexane:EtOAc solvent mixture.

References

[1] Manfred Baumgarth, & Rolf Gericke. “A Concise and Efficient Synthesis of [2-Methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium Methanesulfonate (Eniporide).” European Journal of Organic Chemistry 2000 12 (2000): 2253–2255.

2-Bromo-5-fluorotoluene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluorotoluene Suppliers

Americas 1 Belgium 2 Canada 2 China 354 Europe 3 France 1 Germany 4 India 7 Italy 1 Japan 4 Slovakia 1 Switzerland 1 Ukraine 2 United Kingdom 14 United States 47 Global 444

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 2-Bromo-5-fluorotoluene manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Bromo-5-fluorotoluene 452-63-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Bromo-5-fluorotoluene 452-63-1
Price: US $0.00/KG
Min. Order: 250KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-fluorotoluene 452-63-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-02

452-63-1, 2-Bromo-5-fluorotolueneRelated Search:

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2-BroMo-5-fluorotoluene, 99% 25GR

2-BroMo-5-fluorotoluene, 97+%

2 - broMine - 5 - fluorine toluene

Trelagliptin Impurity 59

2-Bromo-5-fluorotoluene &gt

2-Brom-5-fluortoluol

452-63-1

Aryl

C7

Building Blocks

Halogenated Hydrocarbons

Organic Building Blocks

ARYL HALIDE

alkyl bromide | alkyl Fluorine

Aryl

C7

Halogenated Hydrocarbons

Miscellaneous

Bromine Compounds

Fluorine Compounds

Benzenes

Fluorobenzene

Fluoro-Aromatics

Aromatic Halides (substituted)

Halogen toluene

API intermediates

Fluorin-contained toluene series

bc0001