2-Bromo-5-fluorobenzotrifluoride
- Product Name
- 2-Bromo-5-fluorobenzotrifluoride
- CAS No.
- 40161-55-5
- Chemical Name
- 2-Bromo-5-fluorobenzotrifluoride
- Synonyms
- 5-fluoro-2-bromobenzoTrifluoride;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;2-bromo-5-fluorotrifluorotoluene;2-Bromo-Α,Α,Α,5-Tetrafluorotoluene;2-Bromo-5-fluorobenzotrifluoride 97%;2-Bromo-5-fluorobenzotrifluoride >2-Bromo-5-fluorobenzotrifluoride, 97+%;2-Bromo-5-fluoro-α,α,α-trifluorotoluene;4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE;1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene
- CBNumber
- CB3427370
- Molecular Formula
- C7H3BrF4
- Formula Weight
- 243
- MOL File
- 40161-55-5.mol
2-Bromo-5-fluorobenzotrifluoride Property
- Boiling point:
- 136-143 °C(lit.)
- Density
- 1.695 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.465(lit.)
- Flash point:
- 147 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- BRN
- 2643544
- InChI
- InChI=1S/C7H3BrF4/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
- InChIKey
- AIDVAZGOACECLJ-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(F)C=C1C(F)(F)F
- CAS DataBase Reference
- 40161-55-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Bromo-5-fluorobenzotrifluoride(40161-55-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36/37/39-37-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 546909
- Product name
- 2-Bromo-5-fluorobenzotrifluoride
- Purity
- 97%
- Packaging
- 1g
- Price
- $33.6
- Updated
- 2023/06/20
- Product number
- 546909
- Product name
- 2-Bromo-5-fluorobenzotrifluoride
- Purity
- 97%
- Packaging
- 5g
- Price
- $90
- Updated
- 2023/06/20
- Product number
- B2800
- Product name
- 2-Bromo-5-fluorobenzotrifluoride
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B2800
- Product name
- 2-Bromo-5-fluorobenzotrifluoride
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $97
- Updated
- 2025/07/31
- Product number
- B685778
- Product name
- 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
2-Bromo-5-fluorobenzotrifluoride Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
2-Bromo-5-fluorobenzotrifluoride is an organofluorobenzene compound mainly used as an organic reagent and pharmaceutical intermediate, and can be used as a starting material for the preparation of HSD-016. HSD-016 inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD1) to convert cortisone into cortisol for the development of drugs for the treatment of type 2 diabetes.
Synthesis
393-36-2
40161-55-5
The 1L stainless steel reactor was cooled to -10 °C and then 450 g of anhydrous hydrofluoric acid and 6.0 g of anhydrous potassium fluoride were added to the reactor. Subsequently, 248 g of 5-amino-2-bromobenzotrifluoride was added and 75.5 g of sodium nitrite was added slowly, ensuring that the temperature of the reaction system did not exceed 5 °C. Stirring was done for 30 minutes to complete the diazotization reaction. The temperature of the reaction system was raised to 60°C and maintained, at which time the fluorinated diazonium salt began to decompose slowly and release gases, which were absorbed by the base after passing through the cooling buffer. After the reaction is complete and no more gas is released, the excess hydrofluoric acid in the reactor is recovered and the mixture is cooled to 0°C. A 10% KOH solution was added to the reactor to neutral and steam distillation was carried out to obtain 233 g of crude 2-bromo-5-fluorobenzotrifluoride. The distillation was carried out by filling a distillation column and the 110°C-120°C fractions were collected at a pressure of 40 mmHg to obtain 209 g of a colorless transparent liquid, 2-bromo-5-fluorobenzotrifluoride, with a GC purity of 99% and a yield of 86.8%.
References
[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0023
[2] Patent: CN104447183, 2016, B. Location in patent: Paragraph 0112-0134
[3] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 9
2-Bromo-5-fluorobenzotrifluoride Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-Bromo-5-fluorobenzotrifluoride manufacturers
- Product
- 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-13
- Product
- 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08