ChemicalBook > CAS DataBase List > 2-Bromo-5-fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride

Product Name: 2-Bromo-5-fluorobenzotrifluoride
CAS No.: 40161-55-5
Chemical Name: 2-Bromo-5-fluorobenzotrifluoride
Synonyms: 5-fluoro-2-bromobenzoTrifluoride;2-BROMO-5-FLUOROBENZOTRIFLUORIDE;2-bromo-5-fluorotrifluorotoluene;2-Bromo-Α,Α,Α,5-Tetrafluorotoluene;2-Bromo-5-fluorobenzotrifluoride 97%;2-Bromo-5-fluorobenzotrifluoride >2-Bromo-5-fluorobenzotrifluoride, 97+%;2-Bromo-5-fluoro-α,α,α-trifluorotoluene;4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE;1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene
CBNumber: CB3427370
Molecular Formula: C7H3BrF4
Formula Weight: 243
MOL File: 40161-55-5.mol

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2-Bromo-5-fluorobenzotrifluoride Property

Boiling point:: 136-143 °C(lit.)
Density: 1.695 g/mL at 25 °C(lit.)
refractive index: n20/D 1.465(lit.)
Flash point:: 147 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light orange to Yellow
BRN: 2643544
InChI: InChI=1S/C7H3BrF4/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
InChIKey: AIDVAZGOACECLJ-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C(F)C=C1C(F)(F)F
CAS DataBase Reference: 40161-55-5(CAS DataBase Reference)
NIST Chemistry Reference: 2-Bromo-5-fluorobenzotrifluoride(40161-55-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36/37/39-37-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 546909
Product name: 2-Bromo-5-fluorobenzotrifluoride
Purity: 97%
Packaging: 1g
Price: $33.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: 546909
Product name: 2-Bromo-5-fluorobenzotrifluoride
Purity: 97%
Packaging: 5g
Price: $90
Updated: 2023/06/20

TCI Chemical

Product number: B2800
Product name: 2-Bromo-5-fluorobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B2800
Product name: 2-Bromo-5-fluorobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 25g
Price: $97
Updated: 2025/07/31

TRC

Product number: B685778
Product name: 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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2-Bromo-5-fluorobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

2-Bromo-5-fluorobenzotrifluoride is an organofluorobenzene compound mainly used as an organic reagent and pharmaceutical intermediate, and can be used as a starting material for the preparation of HSD-016. HSD-016 inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD1) to convert cortisone into cortisol for the development of drugs for the treatment of type 2 diabetes.

Synthesis

393-36-2

40161-55-5

The 1L stainless steel reactor was cooled to -10 °C and then 450 g of anhydrous hydrofluoric acid and 6.0 g of anhydrous potassium fluoride were added to the reactor. Subsequently, 248 g of 5-amino-2-bromobenzotrifluoride was added and 75.5 g of sodium nitrite was added slowly, ensuring that the temperature of the reaction system did not exceed 5 °C. Stirring was done for 30 minutes to complete the diazotization reaction. The temperature of the reaction system was raised to 60°C and maintained, at which time the fluorinated diazonium salt began to decompose slowly and release gases, which were absorbed by the base after passing through the cooling buffer. After the reaction is complete and no more gas is released, the excess hydrofluoric acid in the reactor is recovered and the mixture is cooled to 0°C. A 10% KOH solution was added to the reactor to neutral and steam distillation was carried out to obtain 233 g of crude 2-bromo-5-fluorobenzotrifluoride. The distillation was carried out by filling a distillation column and the 110°C-120°C fractions were collected at a pressure of 40 mmHg to obtain 209 g of a colorless transparent liquid, 2-bromo-5-fluorobenzotrifluoride, with a GC purity of 99% and a yield of 86.8%.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0023
[2] Patent: CN104447183, 2016, B. Location in patent: Paragraph 0112-0134
[3] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 9

2-Bromo-5-fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluorobenzotrifluoride Suppliers

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View Lastest Price from 2-Bromo-5-fluorobenzotrifluoride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-13

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-5-fluorobenzotrifluoride 40161-55-5
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

40161-55-5, 2-Bromo-5-fluorobenzotrifluorideRelated Search:

3-Fluorobenzotrifluoride 1,4-Bis(trifluoromethyl)-benzene Xylene 2-Methylbenzotrifluoride 4-Fluorobenzotrifluoride 2-Fluorobenzotrifluoride 4-Bromotoluene 3-Bromo-5-fluorobenzotrifluoride Ethyl bromodifluoroacetate 2-Bromo-5-fluorotoluene Bromobenzene Benzotrifluoride Tosufloxacin tosylate Benzene Bromine 4-BROMO-2-FLUOROBENZOTRIFLUORIDE 5-Amino-4-bromo-2-fluorobenzotrifluoride, 97% Fluorine

4-FLUORO-2-(TRIFLUOROMETHYL)BROMOBENZENE

2-Bromo-5-fluorobenzotrifluoride, 97+%

2-BROMO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE

2-BROMO-5-FLUOROBENZOTRIFLUORIDE

1-BROMO-4-FLUORO-2-(TRIFLUOROMETHYL)BENZENE

1-BROMO-2-(TRIFLUOROMETHYL)-4-FLUOROBENZENE

4-Fluoro-2-trifluoromethyl-phenylboronic acid

5-fluoro-2-bromobenzoTrifluoride

2-Bromo-5-fluorobenzotrifluoride 97%

2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene 1-Bromo-4-fluoro-2-(trifluoromethyl)benzene

1-Bromo-4-fluoro-2-(trifluoromethyl)benzene, 2-Bromo-alpha,alpha,alpha,5-tetrafluorotoluene

Benzene, 1-bromo-4-fluoro-2-(trifluoromethyl)-

2-bromo-5-fluorotrifluorotoluene

2-Bromo-Α,Α,Α,5-Tetrafluorotoluene

1-Bromo-4-Fluor-2-(Trifluoromethyl)Benzene

2-Bromo-5-fluorobenzotrifluoride &gt

2-Bromo-5-fluoro-α,α,α-trifluorotoluene

40161-55-5

41061-55-5

C7H3BrF4

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