2-Bromo-5-fluorotoluene
- Product Name
- 2-Bromo-5-fluorotoluene
- CAS No.
- 452-63-1
- Chemical Name
- 2-Bromo-5-fluorotoluene
- Synonyms
- 1-BROMO-4-FLUORO-2-METHYLBENZENE;2-BROMO-5-FULUOROTOLRENE;2-Bromo-5-fL;2-Bromo-5-fluorotolu;2-Brom-5-fluortoluol;2-Bromo-5-flurotoluene;3-FLUORO-6-BROMOTOLUENE;2-BROMO-5-FLUOROTOLUENE;2-Bromo-5-fuluorotoluene;Trelagliptin Impurity 59
- CBNumber
- CB2145550
- Molecular Formula
- C7H6BrF
- Formula Weight
- 189.02
- MOL File
- 452-63-1.mol
2-Bromo-5-fluorotoluene Property
- Boiling point:
- 177 °C/756 mmHg (lit.)
- Density
- 1.495 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.526(lit.)
- Flash point:
- 113 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Difficult to mix.
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- Specific Gravity
- 1.495
- Water Solubility
- INSOLUBLE
- BRN
- 1859121
- InChI
- InChI=1S/C7H6BrF/c1-5-4-6(9)2-3-7(5)8/h2-4H,1H3
- InChIKey
- RJPNVPITBYXBNB-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(F)C=C1C
- CAS DataBase Reference
- 452-63-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Bromo-5-fluorotoluene(452-63-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36/37/39-37/39
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 365009
- Product name
- 2-Bromo-5-fluorotoluene
- Purity
- 98%
- Packaging
- 25g
- Price
- $32.5
- Updated
- 2025/07/31
- Product number
- 365009
- Product name
- 2-Bromo-5-fluorotoluene
- Purity
- 98%
- Packaging
- 5g
- Price
- $28.6
- Updated
- 2023/01/07
- Product number
- B1303
- Product name
- 2-Bromo-5-fluorotoluene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- B1303
- Product name
- 2-Bromo-5-fluorotoluene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B693463
- Product name
- 2-Bromo-5-fluorotoluene
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
2-Bromo-5-fluorotoluene Chemical Properties,Usage,Production
Chemical Properties
colorless to light yellow liqui
Uses
2-Bromo-5-fluorotoluene is used to produce other chemicals. It can produce 2-Bromo-5-fluoro-benzoic acid. The reaction occurs with reagent KMnO4, solvent H2O and other condition of heating.
Synthesis
108-88-3
612-75-9
452-63-1
95-46-5
31543-75-6
General procedure: The general procedure for the synthesis of 3,3'-dimethylbiphenyl, 2-bromo-5-fluorotoluene, 2-bromotoluene, and 2,4-dibromotoluene from toluene was as follows: boron trifluoride (TFB) was synthesized directly according to the literature methodology [7-9] before use. The corresponding aromatics (4 mmol) were dissolved in Freon R 113 (4.1 mL) and the solution was cooled to -25 °C. Under vigorous stirring, the corresponding TFB (2 mmol) was slowly added to the aryl hydrocarbon solution, followed by removal of the cooling bath. The reaction mixture was stirred at 45 °C for 5 hours. Upon completion of the reaction, the reaction mixture was treated with H2O and filtered to remove the metal fluoride precipitate. The liquid phase was treated with 10% NaNO2 aqueous solution to remove trace bromine and 30% CaCl2 aqueous solution to remove F- anions. Freon R 113 was removed from the organic phase by evaporation and the resulting product was purified by rapid chromatography on silica gel, the eluent being a hexane:EtOAc solvent mixture.
References
[1] Manfred Baumgarth, & Rolf Gericke. “A Concise and Efficient Synthesis of [2-Methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium Methanesulfonate (Eniporide).” European Journal of Organic Chemistry 2000 12 (2000): 2253–2255.
2-Bromo-5-fluorotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluorotoluene manufacturers
- Product
- 2-Bromo-5-fluorotoluene 452-63-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 2-Bromo-5-fluorotoluene 452-63-1
- Price
- US $0.00/KG
- Min. Order
- 250KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-13
- Product
- 2-Bromo-5-fluorotoluene 452-63-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-02