6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
- Product Name
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
- CAS No.
- 6972-27-6
- Chemical Name
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
- Synonyms
- 6-CHLORO-1,3-DIMETHYLURACIL;6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;4-Chlor;AURORA KA-4432;Urapidil Impurity 12;Urapidil Impurity 14;6-Chloro-1,3-dimethyl;4-Chloro-1,3-dimethyluracil;1,3-DIMETHYL-6-CHLOROURACIL;1,3-Dimethyl-4-chlorouracil
- CBNumber
- CB8216650
- Molecular Formula
- C6H7ClN2O2
- Formula Weight
- 174.59
- MOL File
- 6972-27-6.mol
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Property
- Melting point:
- 109-113 °C
- Boiling point:
- 224.6±50.0 °C(Predicted)
- Density
- 1.4926 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- -3.53±0.40(Predicted)
- color
- Pale Yellow
- Water Solubility
- soluble
- BRN
- 144393
- InChI
- InChI=1S/C6H7ClN2O2/c1-8-4(7)3-5(10)9(2)6(8)11/h3H,1-2H3
- InChIKey
- VATQPUHLFQHDBD-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C)C(Cl)=CC(=O)N1C
- CAS DataBase Reference
- 6972-27-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Chloro-2,4-dihydroxy-1,3-dimethylpyrimidine(6972-27-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D1619
- Product name
- 1,3-Dimethyl-6-chlorouracil
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- D1619
- Product name
- 1,3-Dimethyl-6-chlorouracil
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- C596040
- Product name
- 6-Chloro-1,3-dimethyluracil
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC05970
- Product name
- 6-Chloro-1,3-dimethyluracil
- Packaging
- 100g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR480621
- Product name
- 6-Chloro-1,3-dimethyluracil
- Purity
- 98%
- Packaging
- 25g
- Price
- $192
- Updated
- 2021/12/16
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Chemical Properties,Usage,Production
Chemical Properties
white to light yellow flakes or powder
Uses
6-Chloro-1,3-dimethyluracil is a nucleobase constitute of nucleic acid. An intermediate for the synthesis of substituted uracils and derivatives.
Synthesis
769-42-6
6972-27-6
1,3-Dimethylbarbituric acid (compound SM1) (7 kg, 44.9 mmol) was used as raw material and dissolved in 120 kg of phosphoryl chloride (POCl3). Water (2.2 kg, 122 mol) was slowly added dropwise to the above solution. After the dropwise addition, the reaction was slowly heated to reflux and maintained for 6 hours; the reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the reaction solution was slowly poured into a large volume of ice water (100 L) and subsequently extracted twice with dichloromethane (50 L) to combine the organic phases. The organic phase was washed with saturated brine (20 L), dried over anhydrous sodium sulfate, filtered and concentrated the organic phase, and finally the yellow solid product 6-chloro-1,3-dimethyluracil (compound SM2) (7.2 kg) was obtained by vacuum drying in 92.3% yield.
References
[1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987, vol. 23, # 6, p. 690 - 697
[2] Khimiya Geterotsiklicheskikh Soedinenii, 1987, vol. 23, # 6, p. 836 - 844
[3] Patent: CN103755705, 2017, B. Location in patent: Paragraph 0033; 0034; 0035
[4] Justus Liebigs Annalen der Chemie, 1958, vol. 612, p. 158,162
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 869 - 871
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Suppliers
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- Russia
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View Lastest Price from 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione manufacturers
- Product
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30