ChemicalBook > CAS DataBase List > 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione

6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione

Product Name
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
CAS No.
6972-27-6
Chemical Name
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
Synonyms
6-CHLORO-1,3-DIMETHYLURACIL;6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE;4-Chlor;AURORA KA-4432;Urapidil Impurity 12;Urapidil Impurity 14;6-Chloro-1,3-dimethyl;4-Chloro-1,3-dimethyluracil;1,3-DIMETHYL-6-CHLOROURACIL;1,3-Dimethyl-4-chlorouracil
CBNumber
CB8216650
Molecular Formula
C6H7ClN2O2
Formula Weight
174.59
MOL File
6972-27-6.mol
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6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Property

Melting point:
109-113 °C
Boiling point:
224.6±50.0 °C(Predicted)
Density 
1.4926 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
-3.53±0.40(Predicted)
color 
Pale Yellow
Water Solubility 
soluble
BRN 
144393
InChI
InChI=1S/C6H7ClN2O2/c1-8-4(7)3-5(10)9(2)6(8)11/h3H,1-2H3
InChIKey
VATQPUHLFQHDBD-UHFFFAOYSA-N
SMILES
C1(=O)N(C)C(Cl)=CC(=O)N1C
CAS DataBase Reference
6972-27-6(CAS DataBase Reference)
NIST Chemistry Reference
6-Chloro-2,4-dihydroxy-1,3-dimethylpyrimidine(6972-27-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D1619
Product name
1,3-Dimethyl-6-chlorouracil
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
D1619
Product name
1,3-Dimethyl-6-chlorouracil
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$178
Updated
2025/07/31
TRC
Product number
C596040
Product name
6-Chloro-1,3-dimethyluracil
Packaging
25g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC05970
Product name
6-Chloro-1,3-dimethyluracil
Packaging
100g
Price
$80
Updated
2021/12/16
Apolloscientific
Product number
OR480621
Product name
6-Chloro-1,3-dimethyluracil
Purity
98%
Packaging
25g
Price
$192
Updated
2021/12/16
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6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Chemical Properties,Usage,Production

Chemical Properties

white to light yellow flakes or powder

Uses

6-Chloro-1,3-dimethyluracil is a nucleobase constitute of nucleic acid. An intermediate for the synthesis of substituted uracils and derivatives.

Synthesis

769-42-6

6972-27-6

1,3-Dimethylbarbituric acid (compound SM1) (7 kg, 44.9 mmol) was used as raw material and dissolved in 120 kg of phosphoryl chloride (POCl3). Water (2.2 kg, 122 mol) was slowly added dropwise to the above solution. After the dropwise addition, the reaction was slowly heated to reflux and maintained for 6 hours; the reaction process was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the reaction solution was slowly poured into a large volume of ice water (100 L) and subsequently extracted twice with dichloromethane (50 L) to combine the organic phases. The organic phase was washed with saturated brine (20 L), dried over anhydrous sodium sulfate, filtered and concentrated the organic phase, and finally the yellow solid product 6-chloro-1,3-dimethyluracil (compound SM2) (7.2 kg) was obtained by vacuum drying in 92.3% yield.

References

[1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987, vol. 23, # 6, p. 690 - 697
[2] Khimiya Geterotsiklicheskikh Soedinenii, 1987, vol. 23, # 6, p. 836 - 844
[3] Patent: CN103755705, 2017, B. Location in patent: Paragraph 0033; 0034; 0035
[4] Justus Liebigs Annalen der Chemie, 1958, vol. 612, p. 158,162
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 869 - 871

6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione Suppliers

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View Lastest Price from 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-05
Henan Aochuang Chemical Co.,Ltd.
Product
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Career Henan Chemical Co
Product
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 6972-27-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg; 2kg；10kg; 100kg
Release date
2019-08-30

6972-27-6, 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedioneRelated Search:

3-[4-(2-methoxyphenyl)-1-piperazinyl]propanenitrile 1-(2-Methoxyphenyl)piperazine 6-[(3-chloropropyl)amino]-1,3-dimethyluracil URAPIDIL 5-METHYL- Uridine 5''-Monophosphate N,N-Dibutyl-1-butanamine ZEBULARINE Urapidil Impurity 20 Pseudouridine 2-Demethoxy-4-methoxy urapidil Trelagliptin Impurity 18 alpha-Cyclopentylmandelic acid 2-Bromo-5-fluorotoluene Trelagliptin Impurity 20 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Trelagliptin Impurity Y N-METHYLBARBITURIC ACID 4-Fluoro-2-methylbenzonitrile 2-(Bromomethyl)-6-fluorobenzonitrile

  • 1,3-Dimethyl-4-chlorouracil
  • 2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dimethyl-
  • 1,3-DIMETHYL-6-CHLOROURACIL
  • AURORA KA-4432
  • 6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
  • 6-CHLORO-1,3-DIMETHYLURACIL
  • 6-CHLORO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
  • 6-Chloro-1,3-dimethyl
  • 6-CHLORO-1,3-DIMETHYLURACIL 99%
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  • 4-Chloro-1,3-dimethyluracil
  • 6-Chloro-1,3-dimethylpyrimidine-2,4-dione
  • 1,3-Dimethyl-6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 6-Chloro-1,3-dimethyluracil,99%
  • 4-Chlor
  • 6-chloro -1,3-two Methyluracil
  • 6-Chloro-1,3-dimethyluracil,97%
  • 6-chloro-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 13-(1-cyclopent-2-enyl)-N-[4-(2-pyridinylsulfamoyl)phenyl]tridecanamide
  • Tragliptin Starter 1 Impurity 5
  • 1,3-Dimethyl-6-chlorouracil &gt
  • Urapidil Impurity 12
  • Urapidil Impurity 14
  • 6-Chloro-1,3-dimethyluracil D3
  • 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione USP/EP/BP
  • Alogliptin Benzoate Impurity1640
  • 6972-27-6
  • C6H7ClN2O2
  • C6H7N2O2Cl
  • BioChemical
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides