6-Bromohexanoic acid

ChemicalBook > CAS DataBase List > 6-Bromohexanoic acid

6-Bromohexanoic acid

Organic Intermediate

Product Name: 6-Bromohexanoic acid
CAS No.: 4224-70-8
Chemical Name: 6-Bromohexanoic acid
Synonyms: Hexanoic acid, 6-bromo-;6-bromohexanoate;ISBO-007;AKOS BB/0098;6-BroMhexine acid;6-bromo-hexanoicaci;6-BroMhexanoic acid;6-BROMOCAPROIC ACID;RARECHEM AL BO 0317;6-bromohexonic acid
CBNumber: CB6221568
Molecular Formula: C6H11BrO2
Formula Weight: 195.05
MOL File: 4224-70-8.mol

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6-Bromohexanoic acid Property

Melting point:: 32-34 °C (lit.)
Boiling point:: 165-170 °C/20 mmHg (lit.)
Density: 1.3996 (rough estimate)
refractive index: 1.4790 (estimate)
Flash point:: 154 °F
storage temp.: Inert atmosphere,2-8°C
solubility: methanol: 0.1 g/mL, clear, colorless
pka: 4.72±0.10(Predicted)
form: Low Melting Crystals
color: White to light orange
BRN: 1749740
InChIKey: NVRVNSHHLPQGCU-UHFFFAOYSA-N
LogP: 1.700 (est)
CAS DataBase Reference: 4224-70-8(CAS DataBase Reference)
NIST Chemistry Reference: Hexanoic acid, 6-bromo-(4224-70-8)
EPA Substance Registry System: Hexanoic acid, 6-bromo- (4224-70-8)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45-28A
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 8
Hazard Note: Corrosive/Harmful
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29159080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 150452
Product name: 6-Bromohexanoic acid
Purity: 97%
Packaging: 5g
Price: $36.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 150452
Product name: 6-Bromohexanoic acid
Purity: 97%
Packaging: 25g
Price: $74
Updated: 2024/03/01

TCI Chemical

Product number: B1290
Product name: 6-Bromohexanoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $64
Updated: 2024/03/01

TCI Chemical

Product number: B1290
Product name: 6-Bromohexanoic Acid
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $361
Updated: 2024/03/01

Alfa Aesar

Product number: A15761
Product name: 6-Bromohexanoic acid, 98+%
Packaging: 25g
Price: $65.65
Updated: 2024/03/01

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6-Bromohexanoic acid Chemical Properties,Usage,Production

Organic Intermediate

6-bromohexanoic acid(CAS:4224-70-8), also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.

Chemical Properties

White to light orange low melting crystals

Uses

Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2

Uses

6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis.

Uses

6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers.

Definition

ChEBI: 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It is functionally related to a hexanoic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091

Synthesis

The preparation method of the high purity 6-bromocaproic acid: the exsiccant bromize hydrogen gas is directly fed contain in the organic solvent of 6-caprolactone, exsiccant bromize hydrogen gas usage quantity is 6-caprolactone 1.0-2.0 doubly (mol ratio); Stir, ring-opening reaction takes place, temperature of reaction is 0 ℃ ~ 100 ℃, generates high purity 6-bromocaproic acid.

6-Bromohexanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

5-CARBOXY-1-PENTANETHIOL Ethyl 6-bromohexanoate

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View Lastest Price from 6-Bromohexanoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-Bromohexanoic acid 4224-70-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg/month
Release date: 2021-12-27

Hebei Weibang Biotechnology Co., Ltd

Product: 6-Bromohexanoic acid 4224-70-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: 6-Bromohexanoic acid 4224-70-8
Price: US $20.00-2.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-15

4224-70-8, 6-Bromohexanoic acidRelated Search:

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4224-70-8

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蠅-Bromocarboxylic Acids

蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides

Carbonyl Compounds

Carboxylic Acids

Building Blocks

CARBOXYLIC ACID

Organic Building Blocks

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

omega-Functional Alkanols, Carboxylic Acids, Amines & Halides

Aliphatics

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Acids & Esters

Bromine Compounds

omega-Bromocarboxylic Acids