D-Phenylalanine methyl ester hydrochloride

Product Name: D-Phenylalanine methyl ester hydrochloride
CAS No.: 13033-84-6
Chemical Name: D-Phenylalanine methyl ester hydrochloride
Synonyms: H-D-Phe-OMe;H-D-PHE-OME HCL;D-PHENYLALANINE-OME HCL;D-Phe-OMe monohydrochloride;D-DhenylalaninemethylesterHCl;D-PHENYLALANINE ETHYL ESTER HCL;D-PHENYLALANINE METHYL ESTER HCL;R-Phenyl Alanine methyl ester HCL;METHYL D-PHENYLALANINATE HYDROCHLORIDE;D-Dhenylalaninemethylesterhydrochloride
CBNumber: CB6222156
Molecular Formula: C10H14ClNO2
Formula Weight: 215.68
MOL File: 13033-84-6.mol

More

Less

D-Phenylalanine methyl ester hydrochloride Property

Melting point:: 159-163 °C(lit.)
refractive index: -37.0 ° (C=2, EtOH)
storage temp.: 2-8°C
solubility: Soluble in Ethanol and Methanol.
form: Powder or Crystalline Powder
color: White to off-white
InChI: InChI=1/C10H13NO2.ClH/c1-13-10(12)9(11)7-8-5-3-2-4-6-8;/h2-6,9H,7,11H2,1H3;1H/t9-;/s3
InChIKey: SWVMLNPDTIFDDY-SBSPUUFOSA-N
SMILES: C1(C=CC=CC=1)C[C@@H](N)C(=O)OC.Cl |&1:7,r|
CAS DataBase Reference: 13033-84-6(CAS DataBase Reference)

More

Less

Safety

WGK Germany: 3
HS Code: 29224999

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 525472
Product name: D-Phenylalanine methyl ester hydrochloride
Purity: 98%
Packaging: 5g
Price: $27.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 525472
Product name: D-Phenylalanine methyl ester hydrochloride
Purity: 98%
Packaging: 10g
Price: $51.9
Updated: 2025/07/31

TCI Chemical

Product number: P1725
Product name: D-Phenylalanine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: P1725
Product name: D-Phenylalanine Methyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $74
Updated: 2025/07/31

TRC

Product number: P319425
Product name: D-Phenylalanine Methyl Ester Hydrochloride
Packaging: 25g
Price: $185
Updated: 2021/12/16

More

Less

D-Phenylalanine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

D-Phenylalanine Methyl Ester Hydrochloride is a compound useful in organic synthesis used in the preparation of amidines via copper-catalyzed three-component coupling of sulfonyl azides with alkynes and amines.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

673-06-3

13033-84-6

Example 4: General procedure for the synthesis of D-phenylalanine methyl ester hydrochloride: anhydrous methanol (50 mL) was added to a 100 mL two-necked round-bottomed flask equipped with a reflux condenser and a dropping funnel, and the system was cooled to ice bath temperature. Acetyl chloride (3 mL) was slowly added dropwise through the dropping funnel.After 15 min, D-phenylalanine (3 g, 18.16 mmol) was added to the reaction system, followed by refluxing the reaction mixture at 70 °C overnight. Upon completion of the reaction, D-phenylalanine methyl ester hydrochloride was obtained by vacuum drying, and the product could be used for subsequent reactions without further purification. Procedure for synthesizing methyl phthalimide (D-NDI or NDI 3B): 1,4,5,8-naphthalenetetracarboxylic acid dianhydride (200 mg, 0.74 mmol) and D-phenylalanine methyl ester hydrochloride (322 mg, 1.49 mmol) were suspended in DMF (20 mL) in a 100 mL round-bottom flask. Triethylamine (0.6 mL) was added to the suspension under inert atmosphere. The reaction mixture was refluxed at 75 °C for 24 hours. At the end of the reaction, the solvent was removed by vacuum evaporation and the residue was purified by column chromatography (eluent: 1% chloroform solution in methanol) to afford the target product in 71% yield. Product characterization data: 1H NMR (400 MHz, CDCl3): δ8.63 (s, 4H), 7.1 (m, 10H), 6.02 (dd, 2H, J=4Hz, 4Hz), 3.77 (s, 6H), 3.73 (dd, 2H, J=8Hz, 4Hz), 3.50 (dd, 2H, J=12Hz, 4Hz). 13C NMR (400MHz, CDCl3): δ169.6, 162.4, 136.9, 131.3, 129.2, 128.5, 126.9, 126.8, 126.4, 54.9, 52.8, 34.9. mass spectra (EI): m/z=590.17 [M]+ (C34H26N2O8). Elemental analysis results: measured values: C, 69.10; H, 4.49; N, 4.78; calculated values: C, 69.15; H, 4.44; N, 4.74 (C34H26N2O8).

References

[1] Patent: WO2012/98439, 2012, A1. Location in patent: Page/Page column 17
[2] Patent: US6194409, 2001, B1

D-Phenylalanine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

D-Phenylalanine methyl ester hydrochloride Suppliers

Americas 1 Canada 1 China 320 Europe 2 Germany 4 India 17 Japan 3 Poland 1 South Korea 1 Switzerland 5 United Kingdom 8 United States 38 Global 401

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9960
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Yangzhou Xuda Biotechnology Co., Ltd

Tel: 15161820588; 15161820588
Email: xdchemical2024@163.com
Country: China
ProdList: 91
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from D-Phenylalanine methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D-Phenylalanine methyl ester hydrochloride 13033-84-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-08-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: D-Phenylalanine methyl ester hydrochloride 13033-84-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-D-Phe-OMe·HCl 13033-84-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-29

13033-84-6, D-Phenylalanine methyl ester hydrochlorideRelated Search:

Methyl salicylate Topotecan hydrochloride Kresoxim-methyl Phenprobamate Methyl acrylate Tribenuron methyl L-Alanine methyl ester hydrochloride D-Phenylalanine METSULFURON METHYL D-Alanine Methyl Ester Hydrochloride D-Alanine tert-butyl ester hydrochloride D-Prolinamide D-Alanyl-D-alanine H-D-Phe-Leu-OH H-D-PHE-NH2 HCL H-D-Phe-Phe-OMe.HCl Thiophanate-methyl H-D-PHE-OBZL P-TOSYLATE

METHYL D-PHENYLALANINATE HYDROCHLORIDE

D-PHENYLALANINE ETHYL ESTER HCL

D-PHENYLALANINE-OME HCL

D-PHENYLALANINE METHYL ESTER HCL

D-PHENYLALANINE METHYL ESTER HYDROCHLORIDE

D-PHENYLALANINE METHYL ESTER HYDROCHLORIDE SALT

H-D-PHE-OME HCL

(R)-Phenylalanine Methyl Ester Hydrochloride

Methyl (R)-Phenylalaninate Hydrochloride

L-PHENYLALANINE METHYL ESTER HYDROCHLORIDE extrapure

R-Phenyl Alanine methyl ester HCL

D-DhenylalaninemethylesterHCl

D-Dhenylalaninemethylesterhydrochloride

D-Phenylalanine methyl ester hydrochlorid

(R)-methyl 2-amino-3-phenylpropanoate hydrochloride

D-Phenylalanine Metyl ester hydrochloride

H-D-Phe-OMe

D-Phenylalanine methyl ester hydrochloride≥ 98% (HPLC)

D-Phenylalanine Methyl Ester Hydrochloride,99%e.e.

D-Phenylalanine methyleester hydrochloride

D-Phe-OMe monohydrochloride

D-PhenylalanineMethylEsterHydrochloride&gt

D-Phenylalanine methyl ester hydrochloride USP/EP/BP

D-Phenylalanine, methyl ester, hydrochloride (1:1)

D-Phenylalanine methyl ester hydrochlor

<sc>D</sc>-Phenylalanine methyl ester hydrochloride

13033-84-6

156-2-43

3033-84-6

C6H5CH2CHNH2CO2CH3HCL

AMINE

I - Z

Modified Amino Acids

Specialty Synthesis

Peptide Synthesis

Phenylalanine

Amino Acids and Peptides

Biochemicals and Reagents

Amino Acid Derivatives

BioChemical

Heterocyclic Acids

I - ZPeptide Synthesis

Modified Amino Acids

Phenylalanine

Amino Acid Derivatives

Amino Acids

Peptide Synthesis

Amino Acid Derivatives

Amino Acids

Amino Acids 13C, 2H, 15N

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride

Amino Acids & Derivatives