Oral hypoglycemic agents Adverse effects and precautions Chemical Properties Application Production method
ChemicalBook > CAS DataBase List > Metformin hydrochloride

Metformin hydrochloride

Oral hypoglycemic agents Adverse effects and precautions Chemical Properties Application Production method
Product Name
Metformin hydrochloride
CAS No.
1115-70-4
Chemical Name
Metformin hydrochloride
Synonyms
big;Medet;DIABEX;meguan;Nelbis;Metrion;diformin;GlucoMet;GlucoMin;GlucoforM
CBNumber
CB6222671
Molecular Formula
C4H12ClN5
Formula Weight
165.62
MOL File
1115-70-4.mol
More
Less

Metformin hydrochloride Property

Melting point:
223-226 °C(lit.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
form 
Powder
color 
White
Water Solubility 
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
λmax
233nm(H2O)(lit.)
Merck 
14,5938
InChIKey
OETHQSJEHLVLGH-UHFFFAOYSA-N
CAS DataBase Reference
1115-70-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
DU1800000
HS Code 
29252900
Hazardous Substances Data
1115-70-4(Hazardous Substances Data)
Toxicity
LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M-072
Product name
Metformin hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1 mL
Price
$103
Updated
2021/03/22
Sigma-Aldrich
Product number
317240
Product name
Metformin - CAS 1115-70-4 - Calbiochem
Purity
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
Packaging
5 g
Price
$119.32
Updated
2021/03/22
Sigma-Aldrich
Product number
317240
Product name
Metformin
Packaging
5gm
Price
$124
Updated
2020/08/18
Sigma-Aldrich
Product number
M0605000
Product name
Metformin hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$180
Updated
2021/03/22
Sigma-Aldrich
Product number
BP227
Product name
Metformin hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Price
$190
Updated
2021/03/22
More
Less

Metformin hydrochloride Chemical Properties,Usage,Production

Oral hypoglycemic agents

Metformin hydrochloride is a biguanide oral hypoglycemic agent , also known as  Glucophage,  its hypoglycemic effect is weaker than phenformin, the main role is to reduce the glucagon secretion of A cells ,and to promote the conversion of glucose to glycogen, its characteristic effect including that it does not  stimulate pancreatic β-cells to secrete insulin .
The follows are hypoglycemic mechanisms:
1. Increasing the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilization.
2. Increasing glucose utilization of non-insulin-dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and so on.
3. Inhibiting hepatic gluconeogenesis effect , reducing hepatic glucose output.
4. Inhibiting glucose uptake by intestinal cells.
5. Inhibiting the biosynthesis and storage of cholesterol , lowering blood triglycerides and total cholesterol levels.
Metformin hydrochloride is clinically used for the treatment of type Ⅱ diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
At present, domestic manufacturer mainly include the American Shanghai Squibb Pharmaceutical Co., Ltd .

Adverse effects and precautions

Biguanide oral hypoglycemic agents can increase glucose utilization of surrounding tissues and inhibit the intestinal absorption of glucose, and inhibit glycogen gluconeogenesis and hepatic glucose output,it is mainly applied to obesity, dyslipidemia, type II diabetes patients. It almost has no hypoglycemic effect for normal persons ,  2 to 3 hours after taking for diabetes patients ,glucose decreases significantly.
Commonly used oral hypoglycemic agents include phenformin and metformin hydrochloride.
The incidence of adverse effects of metformin hydrochloride is higher than tolbutamide , common gastrointestinal reactions are anorexia, nausea, vomiting, abdominal pain, diarrhea, occasional metallic taste in the mouth, bad breath, nausea, loss of appetite and diarrhea and other gastrointestinal reactions, sometimes  hypoglycemia  is visible  .
Since the biguanide drugs enhance sugar anaerobic glycolysis, and inhibit  glycogen generation, small number of patients may suffer with ketosis or lactic acidosis, which should be particularly vigilant, but metformin effect is weak  , adverse reactions are only  1/50 of other biguanides, and it has rapid clearance, there are no accumulation in the liver, it rarely induces lactic acidosis, sometimes there is mild increase in blood lactate. patients with heart, liver, kidney diseases are prone to these adverse reactions, diabetes patients with these types of complications are hanged. It can reduce the absorption of vitamin B12, but it seldom causes anemia. The following cases are contraindications:
1. Pregnant and lactating women, children under 10 years of age, 80 years of age or older.
2. Diabetic ketoacidosis, diabetic hyperglycemic hyperosmolar syndrome, diabetes lactic acidosis.
3. Severe liver and kidney dysfunction, blood urea nitrogen and creatinine higher than normal, hypovolemic shock, heart failure, AMI, in vivo hypoxic condition such as heart failure, pulmonary insufficiency, or any systemic hypoxia circumstances and other serious heart and lung diseases.
4. Severe infection or trauma, major surgery, clinical hypotension , hypoxia and so on.
5. Complications with severe diabetic nephropathy and retinopathy. When there are symptoms,the drug  should be immediately discontinued; cimetidine can reduce the renal excretion of metformin hydrochloride, agar types can reduce the absorption of metformin, patients must check liver and kidney function and cardiac ketones regularly.
6. Alcoholics, vitamin B12 and folate deficiency which are not corrected.

Chemical Properties

White crystal or crystalline powder. Melting point 232 ℃ (218-220 ℃). Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste.

Application

  • The product belongs to hypoglycemic agents. It can be used in patients with type Ⅱ diabetes to reduce fasting and postprandial hyperglycemia, HbAlc can be decreased by 1% to 2%, hypoglycemic mechanism of this product may be: I increase the sensitivity of peripheral tissues to insulin, increases insulin-mediated glucose utilization . II increase glucose utilization  of non-insulin dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and the like. III inhibit hepatic gluconeogenesis effect, reduce hepatic glucose output. IV inhibit  glucose uptake by intestinal cells.
  • Indications: For mild diabetes.
  • Metformin hydrochloride is an anti-diabetic agent, reducing blood glucose levels, and improving insulin sensitivity. Its metabolites (including the inhibition of hepatic gluconeogenesis) is activated through LKB1-AMPK (AMP-activated protein kinase)  path.
  • Hypoglycemic agents, it is used for non-insulin-dependent diabetes. Rat oral LD50 of 1000 mg/kg.

Production method

After the salifying of dimethylamine and the reaction with dicyandiamide , the product is derived.

Chemical Properties

Crystalline Solid

Originator

Diabetex ,Germania

Uses

An oral hypoglycemic agent

Uses

Anti-diabetic and anti-cancer activity

Definition

ChEBI: A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.

Manufacturing Process

The boiling mixture of 1,000 L xylene, 450 kg dimethylamine and 840 kg dicyanamide was added 365 kg hydrogene chloride. Yield of biguanide, 1,1- dimethyl-, hydrochloride 1,588 kg (96%). Biguanide, 1,1-dimethyl-, hydrochloride may be recrystallysed from methanol.

brand name

Fortamet (Andrx); Glucophage (Bristol-Myers Squibb); Glumetza (Depomed); Riomet(Ranbaxy).

Therapeutic Function

Oral hypoglycemic

Biological Activity

Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.

Veterinary Drugs and Treatments

Metformin may be useful in the adjunctive treatment of non-insulin dependent diabetes mellitus in cats. Only limited trials of the drug have been performed in cats, with only very limited success when the drug is used alone. Studies comparing its safety and efficacy with other oral antihyperglycemics (e.g., glipizide or insulin) were not located.

Metformin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Metformin hydrochloride Suppliers

Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1196-196;028-84555506- ;028-84555506-
Fax
QQ:800101999
Email
cdhxsj@163.com;cdhxsj@163.com;cdhxsj@163.com
Country
China
ProdList
14604
Advantage
60
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8935
Advantage
52
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
027-59212684-
Fax
QQ:2188308251
Email
p19107121455@163.com
Country
China
ProdList
1266
Advantage
58
Shaanxi Pioneer Biotech Co.,Ltd.
Tel
029-84385017-8011
Fax
QQ3502078241
Email
sales@pioneerbiotech.com
Country
China
ProdList
508
Advantage
58
Shandong Suihua Biotechnology Co. Ltd
Tel
Email
freesky2121@hotmail.com
Country
China
ProdList
789
Advantage
58
Hubei Chenxin Pharmaceutical Co., Ltd.
Tel
Fax
QQ:840947394
Email
w17362916295@163.com
Country
China
ProdList
2668
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
More
Less

View Lastest Price from Metformin hydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Metformin HCL 1115-70-4
Price
US $15.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
100T
Release date
2021-06-02
Sinoway Industrial co., ltd.
Product
Metformin Hydrochloride 1115-70-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
98.5% up, EP/ USP / BP
Supply Ability
20tons
Release date
2021-07-12
Anhui Rencheng Technology Co., Ltd
Product
Metformin hydrochloride 1115-70-4
Price
US $1.00-499.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2020-12-31

1115-70-4, Metformin hydrochlorideRelated Search:


  • 1,1-dimethyl-biguanidhydrochloride
  • diabefagos
  • diformin
  • dimethylbiguanidehydrochloride
  • Dimethyldiguanidinehydrochloride
  • GLUCOPHAGE
  • DIABETOSAN
  • DIABEX
  • N,N-DIMETHYLIMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE
  • N,N-DIMETHYLIMIDODICARBONIMIDIC DIAMINE HYDROCHLORIDE
  • Camylofin Di HCL
  • PhenforMin Hydrochloride Tablets
  • GlucoforM
  • GlucoMet
  • GlucoMin
  • GlucoMine
  • SiaMforMet
  • Walaphage
  • MetforMin HCl USP
  • N1,N1-DiMethylbiguanide hydrochloride
  • 1,1-DiMethylbiguanide hydrochloride 97%
  • N,N-dimethyl-imidodicarbonimidic diamide,hydrochloride (1:1)
  • Metformin hydrochloride solution
  • Metformin HCL Extended release
  • Metformin hydrochloride, >=99%
  • Metformin hydrochloride, 98%, an AMPK activator
  • Diabex/Diaqex/Diaqormin
  • Metformin Hcl Powder or Dc
  • Metformin - CAS 1115-70-4 - Calbiochem
  • Metformin hydrochloride, 98%, AMPK activator
  • (15537-72-1) metformin hydrochloride
  • gliformin
  • haurymellin
  • meguan
  • n,n-dimethylbiguanidehydrochloride
  • n,n-dimethyl-imidodicarbonimidicdiamidmonohydrochloride
  • METIGUANIDE
  • METFORMIN HYDROCHLORIDE 99% PHARMACEUTICAL GRADE
  • METFORMIN HYDROCHLORIDE 99%
  • MetforminHclEp
  • MetforminHclMetforminHclBp/Usp/Ep
  • N,N-Dimethylimidodicarbonimidic Diamide Hydrochloride, Diabetosan, Diabex, Glucophage, Metiguanide
  • Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride
  • METFORMINHYDROCHLORIDE,BP
  • 2-(N,N-dimethylcarbamimidoyl)guanidine
  • METFORMIN HCL
  • METFORMIN HYDROCHLORIDE
  • METFORMIN CHLORHYDRATE
  • Diformic acid 3-hydroxy-1,2-propanediyl ester
  • Medet
  • Merformin hydrochloride
  • Metformin·hydrochloric acid
  • Metrion
  • Nelbis
  • Diformic acid 2-hydroxy-1,3-propanediyl ester
  • MetforMin HCL DC
  • 1,1-Dimethylbiguanide hydrochloride,Metformin
  • Metformin Hydrochloride (200 mg)