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2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE

Product Name
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
CAS No.
849461-90-1
Chemical Name
2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
Synonyms
TMPH;nAChR-IN-1;TMPH inhibitor;TMPH HYDROCHLORIDE;TMPH, 10 mM in DMSO;2,2,6,6-Tetramethylpiperidin-4-ylheptanoate;2,2,6,6-Tetramethyl-4-piperidinyl heptanoate;Heptanoic acid, 2,2,6,6-tetramethyl-4-piperidinyl ester;2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE;neurol disorder,nAChR,Nicotinic acetylcholine receptors,neuronal nicotinic receptors,selective inhibition,Inhibitor,inhibit,nicotinic receptor,brain function,tetramethylpiperidinyl heptanoate,dysfunction
CBNumber
CB6227823
Molecular Formula
C16H31NO2
Formula Weight
269.42
MOL File
849461-90-1.mol
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2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Property

storage temp. 
2-8°C
solubility 
H2O: 22 mg/mL at ~60 °C
form 
solid
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37
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Hazard and Precautionary Statements (GHS)

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2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

TMPH Hydrochloride is a potent inhibitor of neuronal AChRs. Therapeutic agent potentially used for the treatment of this progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease.

Definition

ChEBI: Heptanoic acid (2,2,6,6-tetramethyl-4-piperidinyl) ester is a fatty acid ester.

Biological Activity

Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α 3, α 4 and β 2, β 4 respectively). Displays little inhibition of muscle-type ( α 1 β 1 γ δ ) or α 7 receptors.

in vivo

nAChR-IN-1 (20 mg/kg; s.c.; single dose) improves nicotine-induced hypomotility and hypothermia in a time-dependent manner in mice[1].

Animal Model:Nicotine-induced mice model[1]
Dosage:20 mg/kg
Administration:Subcutaneous injection; single dose; 15 minutes prior to the injection of nicotine (1.5 mg/kg)?
Result:Increased locomotor activity in mice, even if nicotine-induced decrease.
Showed no effect on body temperature.
Animal Model:Tail-flick and hot-platemodel in mice[1]
Dosage:0, 0.1, 1, 5 mg/kg
Administration:Subcutaneous injection; single dose
Result:Blocked the antinociceptive effect of nicotine in the hot-plate.
Time-dependently blocked nicotine-induced antinociception.

2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE Suppliers

China 18 Germany 1 Switzerland 1 United Kingdom 1 United States 3 Global 24
3B Pharmachem (Wuhan) International Co.,Ltd.
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849461-90-1, 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDERelated Search:

2,2,6,6-TETRAMETHYLPIPERIDINOL-4 HYDROCHLORIDE 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE

  • 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HEPTANOATE HYDROCHLORIDE
  • TMPH HYDROCHLORIDE
  • 2,2,6,6-Tetramethylpiperidin-4-ylheptanoate
  • Heptanoic acid, 2,2,6,6-tetramethyl-4-piperidinyl ester
  • TMPH
  • neurol disorder,nAChR,Nicotinic acetylcholine receptors,neuronal nicotinic receptors,selective inhibition,Inhibitor,inhibit,nicotinic receptor,brain function,tetramethylpiperidinyl heptanoate,dysfunction
  • TMPH inhibitor
  • TMPH, 10 mM in DMSO
  • 2,2,6,6-Tetramethyl-4-piperidinyl heptanoate
  • nAChR-IN-1
  • 849461-90-1
  • C16H31NO2HCl