Methoxypolyethylene glycols Property

Melting point:

60-64 °C

Boiling point:

>200°C/760mmHg

Density 

1.094 g/mL at 25 °C

vapor density 

>1 (vs air)

vapor pressure 

0.05 mm Hg ( 20 °C)

refractive index 

n20/D 1.459

Flash point:

268 °C

storage temp. 

-20°C

solubility 

H₂O: 50 mg/mL at 25 °C, clear, colorless

form 

semisolid

color 

White to pale yellow

Specific Gravity

1.094

PH

5.5-7.0 (25℃, 50mg/mL in H2O)

Water Solubility 

Slightly miscible with water.

λmax

λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03

Stability:

Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.

InChIKey

XNWFRZJHXBZDAG-UHFFFAOYSA-N

LogP

-0.800 (est)

EPA Substance Registry System

Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy- (9004-74-4)

Safety

Safety Statements 

24/25-22

WGK Germany 

3

RTECS 

PE8271000

F 

3

TSCA 

Yes

HS Code 

29091990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Methoxypolyethylene glycols Chemical Properties,Usage,Production

Description

m-PEG36-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Chemical Properties

varies from viscous liquid to white flakes, depending

Uses

enteric coating controlled release and enteric release coatings

Uses

Methoxypolyethylene Glycol of with an average molecular mass of 350. Methoxypolyethylene Glycol (MPEG) is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.

Uses

Methoxypolyethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes. It has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.

Definition

ChEBI: A poly(ethylene glycol) terminated with a methyl group at one end.

brand name

Carbowax Sentry Methoxypolyethylene Glycol (Union Carbide).

General Description

It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Solubility in organics

Acetone, chloroform, cyclohexanone, dichloromethane, DMF, MEK, toluene (hot), water