(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione

Product Name: (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
CAS No.: 27570-38-3
Chemical Name: (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
Synonyms: Withanone;NSC 179884;Withanone-RM;WITHANONE(SH);Withanone(AS);WITHANONE(SH)(NEW);Withanone solution;Withanone 27570-38-3;(22R)-5α,17α-Dihydroxy-6α,7α;WITHANONE(P)(NEW)(27570-38-3)
CBNumber: CB62286541
Molecular Formula: C28H38O6
Formula Weight: 470.6
MOL File: 27570-38-3.mol

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(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione Property

Boiling point:: 653.7±55.0 °C(Predicted)
Density: 1.264
Flash point:: 216℃
storage temp.: -20°C
solubility: Chloroform: soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble
form: Solid
pka: 12.98±0.70(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: W498960
Product name: Withanone
Packaging: 1mg
Price: $125
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0003255
Product name: WITHANONE
Purity: 95.00%
Packaging: 5MG
Price: $503.7
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 73011
Product name: Withanone
Packaging: 10mg
Price: $990
Updated: 2021/12/16

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(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione Chemical Properties,Usage,Production

Uses

Withanone is used in biological studies as it has therapeutic uses resulting in the reductase inhibition for cancer chemoprevention.

in vivo

Withanone (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Withanone also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity^[1].

Animal Model:	Male Wistar rats (20-24 weeks; 320-360 g) received ICV injection of STZ^[1]
Dosage:	5 mg/kg, 10 mg/kg and 20 mg/kg
Administration:	Oral administration; daily; for 21 days
Result:	Showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Also significantly reversed the decline in acetyl choline and Glutathione (GSH) activity.

IC 50

NMDA Receptor

(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione Suppliers

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View Lastest Price from (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Withanone 27570-38-3 27570-38-3
Price: US $25.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

27570-38-3, (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dioneRelated Search:

Withanolide C WITHANOLIDE A(P) Withanolides Withaphysalin S WITHANOSIDEIV Withaperuvin C Withaphysalin E WITHANOLIDE B(P)(NEW) (1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone (22R)-14,20,22-Trihydroxy-1-oxoergosta-2,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone (13R,22R)-13,14:18,20-Diepoxy-14,18,22-trihydroxy-1-oxo-13,14-secoergosta-2,5,24-trien-26-oic acid 26,22-lactone (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione (S)-2-DECEN-5-OLIDE

(22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione

(22R)-6α,7α-Epoxy-5,17,22-trihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic acid δ-lactone

Withanone

WITHANONE(SH)(NEW)

(5a,6a,7a,22R)-6,7-Epoxy-5,17,22-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone

NSC 179884

WITHANONE(SH)

Withanone 27570-38-3

Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-

Ergosta-2,24-dien-26-oicacid, 6,7-epoxy-5,17,22-trihydroxy-1-oxo-, d-lactone, (5a,6a,7a,22R)-

WITHANONE(P)(NEW)(27570-38-3)

(22R)-5α,17α-Dihydroxy-6α,7α

Withanone(AS)

Withanone-RM

Withanone solution

27570-38-3