ChemicalBook > CAS DataBase List > 1-Boc-pyrrolidine-3-carboxylic acid

1-Boc-pyrrolidine-3-carboxylic acid

Product Name
1-Boc-pyrrolidine-3-carboxylic acid
CAS No.
59378-75-5
Chemical Name
1-Boc-pyrrolidine-3-carboxylic acid
Synonyms
1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-3-CARBOXYLIC ACID;1-N-BOC-BELTA-PROLINE;1-N-BOC-BETA-PROLINE;Daclatasvir Impurity-P;3-CARBOXY-1-BOC-PYRROLIDINE;1-Boc-pyrrolidine-3-carbo...;Benzyl-1-piperazine carbonate;N-Boc-pyrrolidine-3-carboxylate;1-Boc-pyrrolidine-3-carboxylicaci;1-Boc- pyrrolidine -3- formic acid
CBNumber
CB6238560
Molecular Formula
C10H17NO4
Formula Weight
215.25
MOL File
59378-75-5.mol
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1-Boc-pyrrolidine-3-carboxylic acid Property

Melting point:
133-138 °C
Boiling point:
337.2±35.0 °C(Predicted)
Density 
1.201±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Chloroform
form 
powder to crystal
pka
4.47±0.20(Predicted)
color 
White to Light yellow to Light orange
optical activity
0.033°(C=0.01g/ml CHCL3)
InChI
InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
InChIKey
HRMRQBJUFWFQLX-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(O)=O)C1
CAS DataBase Reference
59378-75-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50/53-41
Safety Statements 
26-36/37/39-61-60-39
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706590
Product name
N-Boc-pyrrolidine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$62
Updated
2023/06/20
TCI Chemical
Product number
B3880
Product name
1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic Acid
Purity
>95.0%(GC)(T)
Packaging
1g
Price
$30
Updated
2025/07/31
TRC
Product number
P998020
Product name
Pyrrolidine-1,3-dicarboxylicAcid1-tert-ButylEster
Packaging
5g
Price
$180
Updated
2021/12/16
Usbiological
Product number
261765
Product name
N-Boc-pyrrolidine-3-carboxylic acid
Packaging
1g
Price
$333
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-U0
Product name
Pyrrolidine-3-carboxylic acid, N-Boc protected
Packaging
1g
Price
$16
Updated
2021/12/16
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1-Boc-pyrrolidine-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Gray white solid

Uses

Pyrrolidine-1,3-dicarboxylic Acid 1-tert-Butyl Ester is a reactant used in the synthesis of potent and highly selective ERK1,2 inhibitors.

Synthesis

122684-33-7

72925-16-7

The general procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate was as follows: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol) solution. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, methanol was removed by concentration under reduced pressure. Subsequently, the pH of the solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic layers were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of oily product in 83.00% yield.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059

1-Boc-pyrrolidine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-pyrrolidine-3-carboxylic acid Suppliers

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View Lastest Price from 1-Boc-pyrrolidine-3-carboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-07-08
Henan Aochuang Chemical Co.,Ltd.
Product
1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Shaanxi Dideu Medichem Co. Ltd
Product
1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31

59378-75-5, 1-Boc-pyrrolidine-3-carboxylic acidRelated Search:

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  • N-Boc-pyrrolidine-3-carboxylic acid, CAS 59378-75-5
  • 59378-75-5
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  • C1OH17NO4
  • C10H16NO4
  • Acid
  • Building Blocks
  • C4 to C10
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Carboxylic Acids
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
  • pharmacetical
  • Carboxylic Acids
  • Pyrrolidines
  • Pyrrole&Pyrrolidine&Pyrroline