ChemicalBook > CAS DataBase List > ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE

Product Name: ISOCORYDINE HYDROCHLORIDE
CAS No.: 475-67-2
Chemical Name: ISOCORYDINE HYDROCHLORIDE
Synonyms: luteanin;LUTEANINE;artabotrin;Aids138466;Uzokoridin;Isocorydine;Aids-138466;d-isocorydine;lsocorynoline;l-(+)-isocorydine
CBNumber: CB6238999
Molecular Formula: C20H23NO4
Formula Weight: 341.4
MOL File: 475-67-2.mol

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ISOCORYDINE HYDROCHLORIDE Property

Melting point:: 216-220 °C(lit.)
alpha: D20 +195° (chloroform)
Boiling point:: 477.03°C (rough estimate)
Density: 1.2064 (rough estimate)
refractive index: 1.5614 (estimate)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Cryst.
pka: 9.41±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
InChIKey: QELDJEKNFOQJOY-ZDUSSCGKSA-N
SMILES: N1(C)[C@]2([H])C3=C(C(OC)=C(OC)C=C3CC1)C1=C(O)C(OC)=CC=C1C2

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Safety

WGK Germany: 3
RTECS: CE1057950
Toxicity: LD50 intraperitoneal in mouse: 104mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30101
Product name: Isocorydine
Packaging: 10mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 30101
Product name: Isocorydine
Packaging: 25mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 30101
Product name: Isocorydine
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 30101
Product name: Isocorydine
Packaging: 50mg
Price: $178
Updated: 2024/03/01

Usbiological

Product number: 361810
Product name: Isocorydine
Packaging: 20mg
Price: $546
Updated: 2021/12/16

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ISOCORYDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC₅₀ value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC₅₀ = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC₅₀s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Corydalis tuberosa DC., a plant of the Poppy family.

Uses

Isocorydine is an alkaloid inhibitor of eukaryotic kinases.

Uses

Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.

Uses

sedative, cholinergic

Definition

ChEBI: Isocorydine is an aporphine alkaloid.

in vivo

Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth^[1].

Animal Model:	Female nude mice^[1]
Dosage:	0.4 mg/ml
Administration:	Injected intraperitoneally every 2 days for 2 weeks
Result:	Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.

target

Dopamine Receptor | P450 (e.g. CYP17)

References

See Isocorydine

ISOCORYDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ISOCORYDINE HYDROCHLORIDE manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Isocorydine 475-67-2
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-19

Career Henan Chemical Co

Product: ISOCORYDINE HYDROCHLORIDE 475-67-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

475-67-2, ISOCORYDINE HYDROCHLORIDERelated Search:

(S)-1-(3,4-Dimethoxyphenyl)ethylamine 2-METHOXYBIPHENYL 1-BIPHENYL-2-YL-N-METHYLMETHYLAMINE 4-CHLORO-2-FLUOROBENZYLAMINE HYDROCHLORIDE ISOCORYDINE HYDROCHLORIDE (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol 2,6-Dimethylbenzylamine 3,4,5-TRIMETHYLPHENOL 2,2'-Biphenol 3-[(1S)-1-(Dimethylaminoethyl)]phenol (S)-7-METHOXY-1-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL (R)-4-(1-Aminoethyl)phenol (S)-hydroxybutanedioate salt SALSOLIDINE ISOCORYDINE HYDROCHLORIDE 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE 2,6-DIMETHYL-4-HYDROXYBENZYLAMINE (S)-o-Methyl-a-phenylethylamine 8-methyl-1,2,3,4-tetrahydroisoquinoline

LUTEANINE

LUTEANINE HYDROCHLORIDE

1,2,10-trimethoxy-6a-alpha-aporphin-11-o

4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy

artabotrin

d-isocorydine

l-(+)-isocorydine

luteanin

luteanine(aporphine)

D-ISOCORYDINE HYDROCHLORIDE

(+)-ISOCORYDINE HCL

ISOCORYDINE HCL, (+)-

(+)-ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE

(6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol

11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE

11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE HYDROCHLORIDE

(+)-Isocorynoline hydrochloride

(6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol

[6aS,(+)]-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol

Isocorydine

S-ISOCORYDINE (+)

1,2,10-Trimethoxy-6-methyl-5,6,6A,7-tetrahydro-4H-dibenzo[de,G]quinolin-11-ol

Aids138466

Aids-138466

Aporphin-11-ol, 1,2,10-trimethoxy-

(+)-isocorynoline

Uzokoridin

4H-Dibenzo[de,g]quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)-

Artabotrin|||S-Isocorydine(+)|||Luteanin|||Uzokoridin|||(+)-Isocorynoline

lsocorynoline

475-67-2

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