ChemicalBook > CAS DataBase List > 1-METHYL-2-FORMYLBENZIMIDAZOLE

1-METHYL-2-FORMYLBENZIMIDAZOLE

Product Name: 1-METHYL-2-FORMYLBENZIMIDAZOLE
CAS No.: 3012-80-4
Chemical Name: 1-METHYL-2-FORMYLBENZIMIDAZOLE
Synonyms: AKOS;AKOS BC-1517;ZERENEX EZX001709;TIMTEC-BB SBB010051;1-METHYL-2-FORMYLBENZIMIDAZOLE;1-Methyl-2-formylbenzimidazole 97%;2-Formyl-1-methyl-1H-benzimidazole;1-methyl-2-formyl-1H-benzimidazole;1-Methyl-2-formylbenzimidazole, 99+%;1-methylbenzimidazole-2-carbaldehyde
CBNumber: CB6240789
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 3012-80-4.mol

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1-METHYL-2-FORMYLBENZIMIDAZOLE Property

Melting point:: 114-116 °C
Boiling point:: 286.07°C (rough estimate)
Density: 1.1846 (rough estimate)
refractive index: 1.5570 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Crystalline Powder
pka: 3?+-.0.10(Predicted)
color: Off-white to light beige
Sensitive: Air Sensitive
CAS DataBase Reference: 3012-80-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3687
Product name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Purity: min. 98.0 %
Packaging: 200MG
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: M3687
Product name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Purity: min. 98.0 %
Packaging: 1G
Price: $222
Updated: 2025/07/31

TRC

Product number: M291120
Product name: 1-Methyl-1H-benzimidazole-2-carboxaldehyde
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 065315
Product name: 1-Methyl-1H-benzimidazole-2-carbaldehyde
Purity: 90%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Matrix Scientific

Product number: 009958
Product name: 1-Methyl-1H-benzoimidazole-2-carbaldehyde
Packaging: 500mg
Price: $84
Updated: 2021/12/16

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1-METHYL-2-FORMYLBENZIMIDAZOLE Chemical Properties,Usage,Production

Chemical Properties

OFF-WHITE TO LIGHT BEIGE CRYSTALLINE POWDER

Uses

1-Methyl-1H-benzimidazole-2-carboxaldehyde is a reagent used for the synthesis of dual protein kinase B alpha (AKT) and nuclear factor kappa-light-chain-enchancer of activated B cells (NF-κB) against melanoma.

Synthesis

1632-83-3

20461-86-3

3012-80-4

General procedure for the synthesis of 1-methyl-2-formylbenzimidazole from N-methylbenzimidazole and 2,2-diethoxyacetic acid: N-methylbenzimidazole (0.10 mmol, 1.0 eq.), ammonium persulfate (0.30 mmol, 3.0 eq.), and Cs2CO3 (0.20 mmol, 2.0 eq.) were placed in a dry glass tube. Subsequently, anhydrous DMSO (1 mL) and 2,2-diethoxyacetic acid (0.7 mmol) were added to the tube via syringe under nitrogen protection. The reaction mixture was stirred for 24 h at room temperature using 15 W blue LED strip irradiation. After completion of the reaction, the reaction was quenched by the addition of 1.2 mL of 3.0 M HCl and stirring was continued for 20 hours. Afterwards, the pH was adjusted with saturated Na2CO3 solution and extracted with CH2Cl2. The organic layers were combined, washed with brine and dried over anhydrous Na2SO4. Finally, the target product 1-methyl-2-formylbenzimidazole was purified by rapid chromatography on silica gel, using petroleum ether and ethyl acetate as eluents, and the corresponding yield was calculated.

References

[1] Synlett, 2018, vol. 29, # 14, p. 1881 - 1886

1-METHYL-2-FORMYLBENZIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-2-FORMYLBENZIMIDAZOLE Suppliers

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View Lastest Price from 1-METHYL-2-FORMYLBENZIMIDAZOLE manufacturers

Career Henan Chemical Co

Product: 1-METHYL-2-FORMYLBENZIMIDAZOLE 3012-80-4
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-08

Nanjing jinheyou Trading Co., Ltd.

Product: 1-METHYL-2-FORMYLBENZIMIDAZOLE 3012-80-4
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

3012-80-4, 1-METHYL-2-FORMYLBENZIMIDAZOLERelated Search:

1-METHYL-2-FORMYLBENZIMIDAZOLE 1-METHYLBENZIMIDAZOLE Benzimidazole 1H-Benzimidazole-2-carboxaldehyde 1-(4-CHLOROBENZYL)-1H-BENZIMIDAZOLE-2-CARBALDEHYDE 1H-Benzimidazole-2-carboxaldehyde,1-ethyl-(9CI) 1-METHYL-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID 6H,13H-PYRAZINO[1,2-A:4,5-A']BISBENZIMIDAZOLE-6,13-DIONE CHEMBRDG-BB 4004764 1-BUTYL-1H-BENZIMIDAZOLE-2-CARBALDEHYDE Ethanone, 1-(1-methyl-1H-benzimidazol-2-yl)- (9CI) IFLAB-BB F1076-0005 1-PENTYL-1H-BENZIMIDAZOLE-2-CARBALDEHYDE 1-METHYL-2-BENZIMIDAZOLECARBOXALDEHYDE, S. 1-METHYL-2-FORMYLBENZIMIDAZOLE RARECHEM AL BF 0589 1-PROPYL-1H-BENZOIMIDAZOLE-2-CARBALDEHYDE 1-HEXYL-1H-BENZIMIDAZOLE-2-CARBALDEHYDE 1-(1-PHENETHYL-1H-1,3-BENZIMIDAZOL-2-YL)-1-ETHANONE

ZERENEX EZX001709

TIMTEC-BB SBB010051

1-METHYL-1H-BENZIMIDAZOLE-2-CARBALDEHYDE

1-METHYL-1H-BENZIMIDAZOLE-2-CARBOXALDEHYDE

1-METHYL-1H-BENZOIMIDAZOLE-2-CARBALDEHYDE

1-METHYL-2-FORMYLBENZIMIDAZOLE

AKOS BC-1517

1-methylbenzimidazole-2-carboxaldehyde

1-METHYLBENZIMDAZOLE-2-CARBOXALDEHYDE, 99+%

1-Methylbenzimidazole-2-carboxaldehyde, 99+%

1-Methyl-2-formylbenzimidazole, 99+%

1-Methyl-2-formylbenzimidazole 97%

1H-Benzimidazole-2-carboxaldehyde,1-methyl-(9CI)

1-methyl-1H-benzo[d]imidazole-2-carbaldehyde

1-Methylbenzimidazole-2-carboxaldehyde, 98+%

2-Formyl-1-methyl-1H-benzimidazole

1-Methyl-1H-1,3-benzodiazole-2-carbaldehyde

1-methylbenzimidazole-2-carbaldehyde

AKOS

1H-Benzimidazole-2-carboxaldehyde, 1-methyl-

1-methyl-2-formyl-1H-benzimidazole

3012-80-4

BENZIMIDAZOLE