1-METHYL-2-FORMYLBENZIMIDAZOLE
- Product Name
- 1-METHYL-2-FORMYLBENZIMIDAZOLE
- CAS No.
- 3012-80-4
- Chemical Name
- 1-METHYL-2-FORMYLBENZIMIDAZOLE
- Synonyms
- AKOS;AKOS BC-1517;ZERENEX EZX001709;TIMTEC-BB SBB010051;1-METHYL-2-FORMYLBENZIMIDAZOLE;1-Methyl-2-formylbenzimidazole 97%;2-Formyl-1-methyl-1H-benzimidazole;1-methyl-2-formyl-1H-benzimidazole;1-Methyl-2-formylbenzimidazole, 99+%;1-methylbenzimidazole-2-carbaldehyde
- CBNumber
- CB6240789
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 3012-80-4.mol
1-METHYL-2-FORMYLBENZIMIDAZOLE Property
- Melting point:
- 114-116 °C
- Boiling point:
- 286.07°C (rough estimate)
- Density
- 1.1846 (rough estimate)
- refractive index
- 1.5570 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- 3?+-.0.10(Predicted)
- color
- Off-white to light beige
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 3012-80-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M3687
- Product name
- 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
- Purity
- min. 98.0 %
- Packaging
- 200MG
- Price
- $74
- Updated
- 2025/07/31
- Product number
- M3687
- Product name
- 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $222
- Updated
- 2025/07/31
- Product number
- M291120
- Product name
- 1-Methyl-1H-benzimidazole-2-carboxaldehyde
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 065315
- Product name
- 1-Methyl-1H-benzimidazole-2-carbaldehyde
- Purity
- 90%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 009958
- Product name
- 1-Methyl-1H-benzoimidazole-2-carbaldehyde
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
1-METHYL-2-FORMYLBENZIMIDAZOLE Chemical Properties,Usage,Production
Chemical Properties
OFF-WHITE TO LIGHT BEIGE CRYSTALLINE POWDER
Uses
1-Methyl-1H-benzimidazole-2-carboxaldehyde is a reagent used for the synthesis of dual protein kinase B alpha (AKT) and nuclear factor kappa-light-chain-enchancer of activated B cells (NF-κB) against melanoma.
Synthesis
1632-83-3
20461-86-3
3012-80-4
General procedure for the synthesis of 1-methyl-2-formylbenzimidazole from N-methylbenzimidazole and 2,2-diethoxyacetic acid: N-methylbenzimidazole (0.10 mmol, 1.0 eq.), ammonium persulfate (0.30 mmol, 3.0 eq.), and Cs2CO3 (0.20 mmol, 2.0 eq.) were placed in a dry glass tube. Subsequently, anhydrous DMSO (1 mL) and 2,2-diethoxyacetic acid (0.7 mmol) were added to the tube via syringe under nitrogen protection. The reaction mixture was stirred for 24 h at room temperature using 15 W blue LED strip irradiation. After completion of the reaction, the reaction was quenched by the addition of 1.2 mL of 3.0 M HCl and stirring was continued for 20 hours. Afterwards, the pH was adjusted with saturated Na2CO3 solution and extracted with CH2Cl2. The organic layers were combined, washed with brine and dried over anhydrous Na2SO4. Finally, the target product 1-methyl-2-formylbenzimidazole was purified by rapid chromatography on silica gel, using petroleum ether and ethyl acetate as eluents, and the corresponding yield was calculated.
References
[1] Synlett, 2018, vol. 29, # 14, p. 1881 - 1886
1-METHYL-2-FORMYLBENZIMIDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
1-METHYL-2-FORMYLBENZIMIDAZOLE Suppliers
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
View Lastest Price from 1-METHYL-2-FORMYLBENZIMIDAZOLE manufacturers
- Product
- 1-METHYL-2-FORMYLBENZIMIDAZOLE 3012-80-4
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-08
- Product
- 1-METHYL-2-FORMYLBENZIMIDAZOLE 3012-80-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20