7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE
- Product Name
- 7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE
- CAS No.
- 879-56-1
- Chemical Name
- 7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE
- Synonyms
- 1,2,3,4-Tetrahydro-7-methoxyquinolone;2,3-dihydro-7-methoxy-4(1H)-Quinolinone;7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE;7-methoxy-2,3-dihydro-1h-quinolin-4-one;4(1H)-Quinolinone, 2,3-dihydro-7-methoxy-;7-methoxy-1,2,3,4-tetrahydroquinolin-4-one
- CBNumber
- CB62446385
- Molecular Formula
- C10H11NO2
- Formula Weight
- 177.2
- MOL File
- 879-56-1.mol
7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Off-white to pink Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B593428
- Product name
- 7-methoxy-2,3-dihydroquinolin-4(1H)-one
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- P000476162
- Product name
- 7-Methoxy-2,3-dihydroquinolin-4(1H)-one
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- CHM0986560
- Product name
- 1,2,3,4-TETRAHYDRO-7-METHOXYQUINOLONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.9
- Updated
- 2021/12/16
- Product number
- P000476162
- Product name
- 7-Methoxy-2,3-dihydroquinolin-4(1H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $649
- Updated
- 2021/12/16
- Product number
- 0402CN
- Product name
- 7-Methoxy-2,3-dihydroquinolin-4(1H)-one
- Packaging
- 2.5g
- Price
- $1408
- Updated
- 2021/12/16
7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE Chemical Properties,Usage,Production
Synthesis
3334-67-6
879-56-1
Compounds 1-3 (CAS: 3334-67-6) (40.0 g, 20.5 mmol) were taken as raw material and mixed with polyphosphoric acid (PPA) (100 mL) and the reaction was carried out with mechanical stirring at 90 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to 60 °C and ice water (50 mL) was slowly added under stirring for 30 min. Subsequently, the mixture was extracted using ethyl acetate (EtOAc) (120 mL × 3). The organic phases were combined, washed sequentially with water (40 mL) and brine (40 mL), and then dried with anhydrous Na2SO4. After removal of the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 100/1 (v/v)) to afford the target product, 7-methoxy-2,3-dihydroquinolin-4(1H)-one (Compounds 1-4) (18 g, 50% yield), as a yellow solid. lc-MS (ESI): m/z 178 [M + H]+.
References
[1] Synthesis, 2006, # 11, p. 1791 - 1802
[2] Patent: WO2012/58125, 2012, A1. Location in patent: Page/Page column 112; 113
[3] Patent: WO2007/3934, 2007, A2. Location in patent: Page/Page column 240
[4] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 7, p. 1003 - 1008
7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE Suppliers
- Tel
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- Fax
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- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
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