ChemicalBook > CAS DataBase List > Coluracetam

Coluracetam

Product Name
Coluracetam
CAS No.
135463-81-9
Chemical Name
Coluracetam
Synonyms
BCI-540;COLURACETAM;Colurac tam;MKC-231;BCI-540;Coluracetam, >=99%;Coluracetam, MKC-231;COLURACETAM USP/EP/BP;top quality Coluracetam;MKC-231; MKC231; MKC 231;CAS135463-81-9 COLURACETAM
CBNumber
CB62446491
Molecular Formula
C19H23N3O3
Formula Weight
341.4
MOL File
135463-81-9.mol
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Coluracetam Property

Boiling point:
634.1±55.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form 
A crystalline solid
pka
12.01±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
InChIKey
PSPGQHXMUKWNDI-UHFFFAOYSA-N
SMILES
N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-2196
Product name
Coluracetam
Purity
99.87%
Packaging
10mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
B1158
Product name
Coluracetam
Packaging
10mg
Price
$79
Updated
2021/12/16
ChemScene
Product number
CS-2196
Product name
Coluracetam
Purity
99.87%
Packaging
50mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-2196
Product name
Coluracetam
Purity
99.87%
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-2196
Product name
Coluracetam
Purity
99.87%
Packaging
100mg
Price
$90
Updated
2021/12/16
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Coluracetam Chemical Properties,Usage,Production

Uses

Copiracetam can be used as a nootropic drug to treat memory and intellectual impairments caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development; it also has antidepressant effects.

Pharmacology

Copiracetam has the ability to improve cognition by participating in the HACU process, increasing the rate-limiting step of synaptic intake of choline to synthesize the neurotransmitter acetylcholine, and increasing the activity of cholinergic neurons.

in vitro

Coluracetam (10(-10)-10(-6) moll), also known as MKC-231, significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding.

in vivo

Oral administration of MKC-231 (Coluracetam; 1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested.

Coluracetam Preparation Products And Raw materials

Raw materials

Preparation Products

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Coluracetam Suppliers

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View Lastest Price from Coluracetam manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Coluracetam 135463-81-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-29
Guangzhou Tengyue Chemical Co., Ltd.
Product
Coluracetam 135463-81-9
Price
US $100.00-10.00/kg
Min. Order
1kg
Purity
99% Purity (What/sapp: +86 18145728414)
Supply Ability
1000 Tons/Month
Release date
2024-01-04
Hebei Dangtong Import and export Co LTD
Product
COLURACETAM 135463-81-9
Price
US $108.00-104.00/Grams
Min. Order
50Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17

135463-81-9, ColuracetamRelated Search:

Choline bitartrate CYCLAZOSIN HYDROCHLORIDE Acetamide,N-(2-methyl-4-pyridinyl)- Coluracetam CHEMBRDG-BB 4014008

  • COLURACETAM
  • N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
  • 1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-
  • Coluracetam, MKC-231
  • 1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one
  • BCI-540
  • Coluracetam, >=99%
  • 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide
  • coluracetam cas: 135463-81-9
  • MKC-231;BCI-540
  • MKC-231; MKC231; MKC 231
  • top quality Coluracetam
  • COLURACETAM USP/EP/BP
  • CAS135463-81-9 COLURACETAM
  • Furo(2,3-b)quinoline-1-pyrrolidineacetamide Deriv
  • COLURACETAM MKC-231 BCI-540
  • Colurac tam
  • 135463-81-9
  • Brain health drug
  • Nootropic
  • pharmaceutical intermediate or medicine grade
  • pharmaceutical