GlyH-101

Product Name: GlyH-101
CAS No.: 328541-79-3
Chemical Name: GlyH-101
Synonyms: LYH101;CS-1049;GLYH-101;CFTR Inhibitor II;GlyH-101 (GlyH 101;GlyH-101, 10 mM in DMSO;CFTR Inhibitor II, GlyH-101;CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem;Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II;GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II
CBNumber: CB62446668
Molecular Formula: C19H15Br2N3O3
Formula Weight: 493.15
MOL File: 328541-79-3.mol

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GlyH-101 Property

Melting point:: >300℃ (ethanol )
Density: 1.73±0.1 g/cm3(Predicted)
storage temp.: = -70C
solubility: DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM)
form: Yellow solid
pka: 5.44±0.45(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219675
Product name: InSolutionCFTRInhibitorII,GlyH-101-CAS328541-79-3-Calbiochem
Packaging: 5mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: 219671
Product name: CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem<br />CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 μM in CFTR-expressing FRT cells).
Packaging: 5mg
Price: $222
Updated: 2025/07/31

Cayman Chemical

Product number: 15772
Product name: CFTR Inhibitor II
Purity: ≥95%
Packaging: 5mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 15772
Product name: CFTR Inhibitor II
Purity: ≥95%
Packaging: 25mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 15772
Product name: CFTR Inhibitor II
Purity: ≥95%
Packaging: 50mg
Price: $263
Updated: 2024/03/01

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GlyH-101 Chemical Properties,Usage,Production

Description

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (K_i = 4.3 μM). This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport. Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin. It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.

Uses

N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.

Definition

ChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.

General Description

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; K_i = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

References

[1] R. DE?RAND F B L Bulteau Pignoux. The Cystic Fibrosis Mutation G551D Alters the Non-Michaelis-Menten Behavior of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel and Abolishes the Inhibitory Genistein Binding Site*[J]. The Journal of Biological Chemistry, 2002, 12 1: 35999-36004. DOI: 10.1074/jbc.m206121200
[2] N. D. SONAWANE. Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera[J]. FASEB Journal, 2005, 20 1: 130-132. DOI: 10.1096/fj.05-4818fje
[3] CHATCHAI MUANPRASAT. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.[J]. Journal of General Physiology, 2004, 124 2: 125-137. DOI: 10.1085/jgp.200409059
[4] L J MACVINISH. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.[J]. British Journal of Pharmacology, 2007, 150 8: 1055-1065. DOI: 10.1038/sj.bjp.0707175
[5] JAMES P GARNETT. Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO3? secretion by reciprocal regulation of apical and basolateral membrane Cl?-HCO3? exchangers[J]. British Journal of Pharmacology, 2012, 168 8: 1946-1960. DOI: 10.1111/bph.12085
[6] ERIC S SCHIFFHAUER. Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.[J]. American journal of physiology. Lung cellular and molecular physiology, 2013, 304 5: L324-31. DOI: 10.1152/ajplung.00277.2012
[7] S ZERTAL-ZIDANI. Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse.[J]. Diabetologia, 2013, 56 2: 330-339. DOI: 10.1007/s00125-012-2778-8

GlyH-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GlyH-101 manufacturers

Career Henan Chemical Co

Product: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE 328541-79-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

328541-79-3, GlyH-101Related Search:

GlyH-101

(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE

GLYH-101

Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide

N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II

CFTR Inhibitor II, GlyH-101

N'-[(3,5-DIBROMO-4-HYDROXY-6-OXOCYCLOHEXA-2,4-DIEN-1-YLIDENE)METHYL]-2-(NAPHTHALEN-2-YLAMINO)ACETOHYDRAZIDE

N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE

CFTR Inhibitor II

CS-1049

Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II

GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II

CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;GLYH 101;GLYH101

Glycine, N-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

Inhibitor,antiproliferative,PCT,inhibit,PS120 cells,GlyH101,intestinal fluid,GlyH-101,VSORC,CFTR-like current,Cystic fibrosis transmembrane conductance regulator,CFTR

N'-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide

LYH101

GlyH-101, 10 mM in DMSO

GlyH-101 (GlyH 101

328541-79-3

C19H15Br2N3O3

Inhibitors

CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound.