(4-METHYL-1-NAPHTHALENE)BORONIC ACID
- Product Name
- (4-METHYL-1-NAPHTHALENE)BORONIC ACID
- CAS No.
- 103986-53-4
- Chemical Name
- (4-METHYL-1-NAPHTHALENE)BORONIC ACID
- Synonyms
- AKOS BRN-0320;RARECHEM AH PB 0103;1-Borono-4-methylnaphthalene;4-Methyl-1-naphthylboronic Acid;(4-Methylnaphth-1-yl)boronic acid;1-Methylnaphthalene-4-boronic acid;4-METHYLNAPHTHALENE-1-BORONIC ACID;(4-Methyl-1-naphtalene)boronic acid;4-methylnaphthalen-1-ylboronic acid;(4-METHYL-1-NAPHTHALYL)BORONIC ACID
- CBNumber
- CB6244747
- Molecular Formula
- C11H11BO2
- Formula Weight
- 186.01
- MOL File
- 103986-53-4.mol
(4-METHYL-1-NAPHTHALENE)BORONIC ACID Property
- Melting point:
- 229-235 °C (dec.)(lit.)
- Boiling point:
- 386.3±35.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.95±0.30(Predicted)
- form
- Powder
- color
- White to off-white
- CAS DataBase Reference
- 103986-53-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 521450
- Product name
- 4-Methyl-1-naphthaleneboronic acid
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $236
- Updated
- 2022/05/15
- Product number
- M2457
- Product name
- 4-Methyl-1-naphthaleneboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- M2457
- Product name
- 4-Methyl-1-naphthaleneboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $161
- Updated
- 2025/07/31
- Product number
- M330898
- Product name
- 4-Methyl-1-naphthaleneboronic acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 40087
- Product name
- 4-Methyl-1-naphthaleneboronicacid,95-105%(Assaybytitration)
- Purity
- 95-105%(Assaybytitration)
- Packaging
- 1G
- Price
- $30.24
- Updated
- 2021/12/16
(4-METHYL-1-NAPHTHALENE)BORONIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
Reactant for Suzuki-Miyaura coupling.
Synthesis
5419-55-6
6627-78-7
103986-53-4
3.4. Synthesis of 4-methyl-1-naphthalenylboronic acid: Dissolve 1-bromo-4-methylnaphthalene (1.5 g, 6.78 mmol) in anhydrous ethyl ether (200 mL) and cool the solution to -78°C. Slowly add n-BuLi (1.7 M hexane solution, 10 mL), keeping the temperature at -78 °C. After addition, the reaction mixture was allowed to gradually warm to room temperature and stirred for 2 hours. The reaction mixture was again cooled to -78 °C and a solution of triisopropyl borate (4 g, 4.91 mL, 21.27 mmol) in ether (20 mL) was quickly added. After stirring at -78 °C for 30 min, it was brought to room temperature and continued stirring for 15 hours. Upon completion of the reaction, 100 mL of 2M HCl was added and the milky white emulsion was observed to gradually become clear. The ether layer was separated and the aqueous layer was extracted with ether (3 x 100 mL). All ether extracts were combined, dried with MgSO4, and the solvent was removed by rotary evaporation. The residual solid was recrystallized with hot CH2Cl2 to give a white solid product. Yield: 95%.1H NMR (300 MHz, CD2Cl2): δ 9.33 (d, J = 9.3 Hz, 1H), 8.59 (d, J = 7.0 Hz, 1H), 8.16 (d, J = 9.5 Hz, 1H), 7.65 (dd, 2H), 7.54 (d, J = 7.6 Hz, 1H), 2.82 (s, 3H). 13C NMR (75 MHz, CD2Cl2): δ 140.3, 137.5, 132.8, 132.3, 128.6, 126.5, 126.3, 125.9, 125.7, 124.6, 19.5; MS (CI, CH4): m/z calcd for C11H11BO2: 186.1; found : 186.1 [M+]. Calcd for C11H11BO2-H2O: C, 64.75; H, 6.42. Found: C, 62.91; H, 5.64.
References
[1] Tetrahedron, 2012, vol. 68, # 46, p. 9371 - 9375,5
[2] Tetrahedron,
[3] Patent: CN107814795, 2018, A. Location in patent: Paragraph 0028; 0030
[4] Patent: CN107973777, 2018, A. Location in patent: Paragraph 0042; 0045; 0046
[5] Patent: CN108129453, 2018, A. Location in patent: Paragraph 0041; 0042; 0045; 0046
(4-METHYL-1-NAPHTHALENE)BORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(4-METHYL-1-NAPHTHALENE)BORONIC ACID Suppliers
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View Lastest Price from (4-METHYL-1-NAPHTHALENE)BORONIC ACID manufacturers
- Product
- (4-METHYL-1-NAPHTHALENE)BORONIC ACID 103986-53-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- (4-METHYL-1-NAPHTHALENE)BORONIC ACID 103986-53-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- (4-METHYL-1-NAPHTHALENE)BORONIC ACID 103986-53-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 812
- Release date
- 2019-09-02