1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE

Product Name: 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
CAS No.: 104113-71-5
Chemical Name: 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
Synonyms: NPPI;TIMTEC-BB SBB003161;1-(1-NAPHTHYL)PIPERAZINE;1-(1-Naphthalenyl)piperazine;1-(1-NAPHTHYL)PIPERAZINE HCL;1-(Piperazin-1-yl)naphthalene;1-(1-Naphthyl)piperazine*2HCl;1-(Naphth-1-yl)piperazine diHCl;1-(Naphthalen-1-yl)piperazineHCl;1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
CBNumber: CB6244792
Molecular Formula: C14H17ClN2
Formula Weight: 248.75
MOL File: 104113-71-5.mol

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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Property

Melting point:: 235-237 °C
storage temp.: Store at -20°C
solubility: H₂O: soluble
form: needles
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62097
Product name: 1-(1-Naphthyl)piperazine hydrochloride
Packaging: 1g
Price: $276
Updated: 2024/03/01

Alfa Aesar

Product number: J62097
Product name: 1-(1-Naphthyl)piperazine hydrochloride
Packaging: 5g
Price: $661
Updated: 2023/06/20

Cayman Chemical

Product number: 16150
Product name: 1-(1-Naphthyl) piperazine (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 16150
Product name: 1-(1-Naphthyl) piperazine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 16150
Product name: 1-(1-Naphthyl) piperazine (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $217
Updated: 2024/03/01

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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT₁ and 5-HT₂ in rat cortical membranes with IC₅₀ values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC₅₀ = 1 nM for both agonists). 1-NP mimics the 5-HT₁ agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, ) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT₁ receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT₆ receptor with an affinity comparable to that of 5-HT (K_is = 120 and 100 nM, respectively).

Uses

1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.

in vitro

1-np binds to human 5- ht6 (h5-ht6) serotonin receptors with a ki of 120 nm [1]. in rat cortical membranes, 1-np inhibited the activity of 5-ht1 and 5-ht2 with ic50 values of 6 and 1 nm, respectively. 1-np also blocked contraction in the rat fundus induced by either 5-ht or tryptamine with an ic50 of 1 nm [3].

in vivo

in squirrel monkeys, 1-np (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (fi) schedules of presentation of food caused by dob (0.01–0.3 mg/kg), an agonist of 5-ht2. 1-np also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-ht2 actions [4].

References

[1] lee m, rangisetty j b, pullagurla m r, et al. 1-(1-naphthyl) piperazine as a novel template for 5-ht 6 serotonin receptor ligands[j]. bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
[2] nichols d e, nichols c d. serotonin receptors[j]. chemical reviews, 2008, 108(5): 1614-1641.
[3] cohen m l, wittenauer l a. relationship between serotonin and tryptamine receptors in the rat stomach fundus[j]. journal of pharmacology and experimental therapeutics, 1985, 233(1): 75-79.
[4] mckearney j w. serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[j]. neuropharmacology, 1989, 28(8): 817-821.

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Suppliers

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View Lastest Price from 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 104113-71-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-18

104113-71-5, 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDERelated Search:

1-(1-NAPHTHYL)PIPERAZINE 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 1-(2-NAPHTHYL)PIPERAZINE 4-(1-NAPHTHYL)PIPERAZINE-1-CARBOTHIOAMIDE 2-(2-Naphthyl)piperazine 1-(1-NAPHTHYL)PIPERAZINE DIHYDROCHLORID 4-(2-NAPHTHYL)PIPERAZINE-1-CARBOTHIOAMIDE 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE AKOS BB-5402 1-(1-NAPHTHYL)PIPERAZINE DIHYDROCHLORIDE 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE AKOS BB-4741

TIMTEC-BB SBB003161

NPPI

1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE

1-(1-NAPHTHYL)PIPERAZINE

1-(1-NAPHTHYL)PIPERAZINE HCL

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE

1-(1-Naphthalenyl)piperazine

1-(Piperazin-1-yl)naphthalene

1-(Naphthalen-1-yl)piperazineHCl

1-(1-Naphthyl)piperazine*2HCl

Piperazine, 1-(1-naphthalenyl)-, hydrochloride (1:1)

1-(Naphth-1-yl)piperazine diHCl

Piperazine, 1-(1-naphthalenyl)-, monohydrochloride

1 (1 Naphthyl) piperazine hydrochloride,1(1Naphthyl) piperazine hydrochloride

104113-71-5