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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE

Product Name
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
CAS No.
104113-71-5
Chemical Name
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
Synonyms
NPPI;TIMTEC-BB SBB003161;1-(1-NAPHTHYL)PIPERAZINE;1-(1-Naphthalenyl)piperazine;1-(1-NAPHTHYL)PIPERAZINE HCL;1-(Piperazin-1-yl)naphthalene;1-(1-Naphthyl)piperazine*2HCl;1-(Naphth-1-yl)piperazine diHCl;1-(Naphthalen-1-yl)piperazineHCl;1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
CBNumber
CB6244792
Molecular Formula
C14H17ClN2
Formula Weight
248.75
MOL File
104113-71-5.mol
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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Property

Melting point:
235-237 °C
storage temp. 
Store at -20°C
solubility 
H2O: soluble
form 
needles
color 
white
InChI
InChI=1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16;/h1-7,15H,8-11H2;1H
InChIKey
ZYVYPNZFOCZLEM-UHFFFAOYSA-N
SMILES
C1(C=CC=C2C=CC=CC=12)N1CCNCC1.Cl
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16150
Product name
1-(1-Naphthyl) piperazine (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
16150
Product name
1-(1-Naphthyl) piperazine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
16150
Product name
1-(1-Naphthyl) piperazine (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$217
Updated
2024/03/01
Cayman Chemical
Product number
16150
Product name
1-(1-Naphthyl) piperazine (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$502
Updated
2024/03/01
TRC
Product number
N378123
Product name
1-(1-Naphthyl)piperazinemiddotHCl
Packaging
20mg
Price
$40
Updated
2021/12/16
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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists). 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, ) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1 receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).

Uses

1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.

in vitro

1-np binds to human 5- ht6 (h5-ht6) serotonin receptors with a ki of 120 nm [1]. in rat cortical membranes, 1-np inhibited the activity of 5-ht1 and 5-ht2 with ic50 values of 6 and 1 nm, respectively. 1-np also blocked contraction in the rat fundus induced by either 5-ht or tryptamine with an ic50 of 1 nm [3].

in vivo

in squirrel monkeys, 1-np (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (fi) schedules of presentation of food caused by dob (0.01–0.3 mg/kg), an agonist of 5-ht2. 1-np also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-ht2 actions [4].

IC 50

5-HT1A Receptor; 5-HT2A Receptor

References

[1] lee m, rangisetty j b, pullagurla m r, et al. 1-(1-naphthyl) piperazine as a novel template for 5-ht 6 serotonin receptor ligands[j]. bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
[2] nichols d e, nichols c d. serotonin receptors[j]. chemical reviews, 2008, 108(5): 1614-1641.
[3] cohen m l, wittenauer l a. relationship between serotonin and tryptamine receptors in the rat stomach fundus[j]. journal of pharmacology and experimental therapeutics, 1985, 233(1): 75-79.
[4] mckearney j w. serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[j]. neuropharmacology, 1989, 28(8): 817-821.

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Suppliers

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View Lastest Price from 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 104113-71-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-18

104113-71-5, 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDERelated Search:

1-(1-NAPHTHYL)PIPERAZINE 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 1-(2-NAPHTHYL)PIPERAZINE 4-(1-NAPHTHYL)PIPERAZINE-1-CARBOTHIOAMIDE 2-(2-Naphthyl)piperazine 1-(1-NAPHTHYL)PIPERAZINE DIHYDROCHLORID 4-(2-NAPHTHYL)PIPERAZINE-1-CARBOTHIOAMIDE 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE AKOS BB-5402 1-(1-NAPHTHYL)PIPERAZINE DIHYDROCHLORIDE 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE AKOS BB-4741

  • TIMTEC-BB SBB003161
  • NPPI
  • 1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE
  • 1-(1-NAPHTHYL)PIPERAZINE
  • 1-(1-NAPHTHYL)PIPERAZINE HCL
  • 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
  • 1-(1-Naphthalenyl)piperazine
  • 1-(Piperazin-1-yl)naphthalene
  • 1-(Naphthalen-1-yl)piperazineHCl
  • 1-(1-Naphthyl)piperazine*2HCl
  • Piperazine, 1-(1-naphthalenyl)-, hydrochloride (1:1)
  • 1-(Naphth-1-yl)piperazine diHCl
  • Piperazine, 1-(1-naphthalenyl)-, monohydrochloride
  • 1 (1 Naphthyl) piperazine hydrochloride,1(1Naphthyl) piperazine hydrochloride
  • 1-(1-Naphthyl) piperazine hydrochloride, 10 mM in DMSO
  • 104113-71-5