EPTAPIRONE
- Product Name
- EPTAPIRONE
- CAS No.
- 179756-58-2
- Chemical Name
- EPTAPIRONE
- Synonyms
- F 11440;EPTAPIRONE;F-11440;F11440;Eptapirone(F11440);4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440
- CBNumber
- CB62448965
- Molecular Formula
- C16H23N7O2
- Formula Weight
- 345.4
- MOL File
- 179756-58-2.mol
EPTAPIRONE Property
- Boiling point:
- 517.4±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF:10.0(Max Conc. mg/mL);28.95(Max Conc. mM)
- form
- A crystalline solid
- pka
- 7.72±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23449
- Product name
- Eptapirone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 23449
- Product name
- Eptapirone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 23449
- Product name
- Eptapirone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
- Product number
- 23449
- Product name
- Eptapirone
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- E591305
- Product name
- Eptapirone
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
EPTAPIRONE Chemical Properties,Usage,Production
Description
Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia.
Uses
Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential.
Definition
ChEBI: Eptapirone is a N-arylpiperazine.
EPTAPIRONE Preparation Products And Raw materials
Raw materials
Preparation Products
EPTAPIRONE Suppliers
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View Lastest Price from EPTAPIRONE manufacturers
- Product
- EPTAPIRONE 179756-58-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25