EPTAPIRONE

ChemicalBook > CAS DataBase List > EPTAPIRONE

Product Name: EPTAPIRONE
CAS No.: 179756-58-2
Chemical Name: EPTAPIRONE
Synonyms: F 11440;EPTAPIRONE;F-11440;F11440;Eptapirone(F11440);4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440
CBNumber: CB62448965
Molecular Formula: C16H23N7O2
Formula Weight: 345.4
MOL File: 179756-58-2.mol

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EPTAPIRONE Property

Boiling point:: 517.4±60.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF:10.0(Max Conc. mg/mL);28.95(Max Conc. mM)
form: A crystalline solid
pka: 7.72±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23449
Product name: Eptapirone
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23449
Product name: Eptapirone
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 23449
Product name: Eptapirone
Purity: ≥98%
Packaging: 10mg
Price: $301
Updated: 2024/03/01

Cayman Chemical

Product number: 23449
Product name: Eptapirone
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

TRC

Product number: E591305
Product name: Eptapirone
Packaging: 10mg
Price: $175
Updated: 2021/12/16

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EPTAPIRONE Chemical Properties,Usage,Production

Description

Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT_1A (K_i = 4.8 nM in a radioligand binding assay). It is selective for 5-HT_1A over other 5-HT receptor subtypes, dopamine D₂ receptors, α₁-adrenergic receptors, and histamine H₁ receptors (K_is = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT_1A receptors (EC₅₀ = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED₅₀ = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED₅₀s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia.

Uses

Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential.

Definition

ChEBI: Eptapirone is a N-arylpiperazine.

EPTAPIRONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from EPTAPIRONE manufacturers

Career Henan Chemical Co

Product: EPTAPIRONE 179756-58-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

179756-58-2, EPTAPIRONERelated Search:

EPTAPIRONE

4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione

F 11440

4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione

F-11440;F11440

1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-

Eptapirone(F11440)

Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440

179756-58-2