1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE
- Product Name
- 1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE
- CAS No.
- 769944-78-7
- Chemical Name
- 1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE
- Synonyms
- N-Boc-4-(4-broMophenyl)piperidine;1-Boc-4-(4-Bromo-phenyl)-piperidine;1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE;1-N-Boc-4-(5-Bromophenyl)piperidine;4-(N-Boc-piperidin-4-yl)bromobenzene;4-(4-bromophenyl)piperidine-1-carboxylate;tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate 98%min;4-(4-BROMO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylic acid, 4-(4-bromophenyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB62451929
- Molecular Formula
- C16H22BrNO2
- Formula Weight
- 340.26
- MOL File
- 769944-78-7.mol
1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE Property
- Boiling point:
- 398.5±42.0 °C(Predicted)
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.75±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B201048
- Product name
- 1-N-BOC-4-(4-bromophenyl)piperidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B201048
- Product name
- 1-N-BOC-4-(4-bromophenyl)piperidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB144272
- Product name
- tert-Butyl 4-(4-bromophenyl)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FB144272
- Product name
- tert-Butyl 4-(4-bromophenyl)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W8369
- Product name
- 1-N-Boc-4-(4-Bromophenyl)piperidine
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE Chemical Properties,Usage,Production
Synthesis
80980-89-8
24424-99-5
769944-78-7
Part A: 4-(4-bromophenyl)piperidine (960 mg, 4.0 mmol) was mixed with di-tert-butyl dicarbonate (960 mg, 4.4 mmol) in dichloromethane (DCM, 10 mL) at 0 °C. The reaction was completed by LC-MS analysis. After confirming the completion of the reaction by LC-MS analysis, additional dichloromethane (10 mL) was added to dilute the reaction mixture. Subsequently, the reaction mixture was washed with 1N HCl (10 mL) to remove unreacted feedstock and by-products. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by fast column chromatography using gradient elution (0 to 100% hexane/ethyl acetate) conditions to afford the target compound 1-N-Boc-4-(4-bromophenyl)piperidine (Compound 2) as a white solid (1.36 g, 100% yield). HPLC-MS analysis showed retention time t R = 2.50 min (UV detection wavelength 2*nm), the The mass calculated value was C16H22BrNO2[M+H]+ 339.1 and the actual observed LCMS m/z was 284.1 (M+H-tBu).
References
[1] Patent: WO2010/17060, 2010, A1. Location in patent: Page/Page column 31
[2] Patent: WO2009/158369, 2009, A1. Location in patent: Page/Page column 50
[3] Patent: WO2017/11776, 2017, A1. Location in patent: Paragraph 00698; 00699; 00700
[4] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 253
[5] Patent: WO2007/97937, 2007, A1. Location in patent: Page/Page column 188-189
1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-BOC-4-(4-BROMOPHENYL)PIPERIDINE manufacturers
- Product
- 1-N-Boc-4-(4-Bromophenyl)Piperidine 769944-78-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09