ChemicalBook > CAS DataBase List > 4-FORMYLCINNAMIC ACID METHYL ESTER

4-FORMYLCINNAMIC ACID METHYL ESTER

Product Name: 4-FORMYLCINNAMIC ACID METHYL ESTER
CAS No.: 58045-41-3
Chemical Name: 4-FORMYLCINNAMIC ACID METHYL ESTER
Synonyms: Methyl (E)-3-(4-formylphenyl)acrylate;Ozagrel-023-E;Ozagrel Impurity 63;Methyl (E)-p-formylcinnamate;(E)-4- mylcinnamic Acid Methyl Ester;(E)-4-Formylcinnamic Acid Methyl Ester;(E)-3-(4-Formyl-phenyl)-acrylic acid methyl ester;(E)-3-(4-Formylphenyl)-2-propenoic acid methyl ester;(2E)-3-(4-ForMylphenyl)-2-propenoic Acid Methyl Ester;2-Propenoic acid, 3-(4-formylphenyl)-, methyl ester, (2E)-
CBNumber: CB62452395
Molecular Formula: C11H10O3
Formula Weight: 190.2
MOL File: 58045-41-3.mol

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4-FORMYLCINNAMIC ACID METHYL ESTER Property

Melting point:: 79-82 ºC
Boiling point:: 334.1±25.0 °C(Predicted)
Density: 1.173
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow
InChI: InChI=1S/C11H10O3/c1-14-11(13)7-6-9-2-4-10(8-12)5-3-9/h2-8H,1H3/b7-6+
InChIKey: KVXMLLMZXPRPNG-VOTSOKGWSA-N
SMILES: C(OC)(=O)/C=C/C1=CC=C(C=O)C=C1

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Safety

WGK Germany: 3
HS Code: 2918300090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735337
Product name: Methyl 4-formylcinnamate
Purity: 97%
Packaging: 1g
Price: $74.48
Updated: 2025/07/31

TRC

Product number: F698540
Product name: (E)-4-FormylcinnamicAcidMethylEster
Packaging: 1g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 8581AB
Product name: (E)-Methyl3-(4-formylphenyl)acrylate
Packaging: 25g
Price: $666
Updated: 2021/12/16

Ambeed

Product number: A140518
Product name: (E)-Methyl3-(4-formylphenyl)acrylate
Purity: 98%
Packaging: 5g
Price: $148
Updated: 2021/12/16

Ambeed

Product number: A140518
Product name: (E)-Methyl3-(4-formylphenyl)acrylate
Purity: 98%
Packaging: 250mg
Price: $16
Updated: 2021/12/16

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4-FORMYLCINNAMIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Cinnamic Acid derivative

Synthesis Reference(s)

Synthesis, p. 747, 1984 DOI: 10.1055/s-1984-30956

Synthesis

104-88-1

292638-85-8

7560-50-1

GENERAL PROCEDURE: To a 25 mL round-bottomed flask was added p-chlorobenzaldehyde (1.00 mmol), methyl acrylate (0.130 g, 1.50 mmol), triethylamine (0.152 g, 1.50 mmol) and N,N-dimethylformamide (DMF, 5 mL). DMF solution containing catalyst (catalyst concentrations of 0.1, 0.01 and 0.001 mol%, see Table 1; 0.01 mol%, see Table 2) was added to the above mixture via syringe. The flask was assembled to a water condenser with an anhydrous calcium chloride drying tube, and the reaction mixture was continuously stirred and heated in an oil bath at 90°C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently poured into distilled water (300 mL). The product in the aqueous phase was extracted with ethyl acetate (5 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product as an oil. Purification of the crude product by silica gel column chromatography (eluent hexane/ethyl acetate, gradient from 10/0 to 8/2, v/v) gave methyl 3-(4-formylphenyl)acrylate as shown in Tables 1 and 2.

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 8036 - 8041
[2] Polyhedron, 2018, vol. 151, p. 313 - 322
[3] Tetrahedron Letters, 2011, vol. 52, # 37, p. 4782 - 4787
[4] New Journal of Chemistry, 2016, vol. 40, # 2, p. 1250 - 1255
[5] ChemCatChem, 2013, vol. 5, # 8, p. 2418 - 2424

4-FORMYLCINNAMIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-FORMYLCINNAMIC ACID METHYL ESTER manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 4-FORMYLCINNAMIC ACID METHYL ESTER 58045-41-3
Price: US $39.00-600.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 30
Release date: 2024-07-12

Career Henan Chemical Co

Product: 4-FORMYLCINNAMIC ACID METHYL ESTER 58045-41-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-03

58045-41-3, 4-FORMYLCINNAMIC ACID METHYL ESTERRelated Search:

Benzeneethanol, 4-[1-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1-methylethyl]-, 4-methylbenzenesulfonate (ester) 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, Methyl ester, (2E)- Bilastine 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)- 2-(1-(4-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)propan- 2-yl)phenethyl)piperidin-4-yl)-1H-benzo[d]imidazole 4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL Methyl 4-hydroxycinnamate methyl (E)-3-(4-formylphenyl)acrylate 4-Formylcinnamic acid 4-FORMYLCINNAMIC ACID METHYL ESTER 3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER 3-(4-CYCLOPROPANECARBONYL-PHENYL)-ACRYLIC ACID METHYL ESTER (E)-3-(4-ACETYL-PHENYL)-ACRYLIC ACID BUTYL ESTER RARECHEM AL BR 0110 (E)-3-(4-ACETYL-PHENYL)-ACRYLIC ACID TERT-BUTYL ESTER 4-[(1E)-3-ETHOXY-3-OXOPROP-1-EN-1-YL]BENZOIC ACID 3-(1-OXO-INDAN-5-YL)-ACRYLIC ACID METHYL ESTER

(E)-3-(4-Formylphenyl)-2-propenoic acid methyl ester

Methyl (E)-3-(4-formylphenyl)acrylate

Methyl (E)-p-formylcinnamate

(2E)-3-(4-ForMylphenyl)-2-propenoic Acid Methyl Ester

(E)-4-Formylcinnamic Acid Methyl Ester

(E)-3-(4-Formyl-phenyl)-acrylic acid methyl ester

(E)-4- mylcinnamic Acid Methyl Ester

2-Propenoic acid, 3-(4-formylphenyl)-, methyl ester, (2E)-

Ozagrel-023-E

Ozagrel Impurity 63

58045-41-3

Aromatics

Miscellaneous Reagents