5-METHYL-1,2-BENZISOXAZOL-3-AMINE
- Product Name
- 5-METHYL-1,2-BENZISOXAZOL-3-AMINE
- CAS No.
- 89976-56-7
- Chemical Name
- 5-METHYL-1,2-BENZISOXAZOL-3-AMINE
- Synonyms
- 3-Amino-5-methylbenzisoxazole;5-METHYL-1,2-BENZISOXAZOL-3-AMINE;1,2-Benzisoxazol-3-amine, 5-methyl-;5-Methyl-benzo[d]isoxazol-3-ylaMine
- CBNumber
- CB62452461
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 89976-56-7.mol
5-METHYL-1,2-BENZISOXAZOL-3-AMINE Property
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Appearance
- Light yellow to orange Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M222918
- Product name
- 5-Methylbenzo[D]isoxazol-3-amine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- M222918
- Product name
- 5-Methylbenzo[D]isoxazol-3-amine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR927597
- Product name
- 5-Methylbenzo[d]isoxazol-3-amine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CHM0101483
- Product name
- 5-METHYLBENZO[D]ISOXAZOL-3-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.4
- Updated
- 2021/12/16
- Product number
- 4945AC
- Product name
- 5-Methylbenzo[d]isoxazol-3-amine
- Packaging
- 1g
- Price
- $257
- Updated
- 2021/12/16
5-METHYL-1,2-BENZISOXAZOL-3-AMINE Chemical Properties,Usage,Production
Synthesis
64113-84-4
127-06-0
89976-56-7
General procedure for the synthesis of 5-methylbenzo[d]isoxazol-3-amine from 2-fluoro-5-methylbenzonitrile and acetone oxime: potassium tert-butoxide (4.57 g, 40.8 mmol, 1.1 eq.) was suspended in tetrahydrofuran (THF, 40 mL). Acetone oxime (2.97 g, 40.7 mmol, 1.1 eq.) was added and the reaction mixture was stirred for 20 min at room temperature. Subsequently, a THF solution (30 mL) of 2-fluoro-5-methylbenzyl cyanide (5.00 g, 37 mmol, 1.0 eq.) was added slowly and dropwise. After continued stirring for 3 h at room temperature, the reaction mixture was refluxed overnight. Upon completion of the reaction, the reaction was quenched with deionized water (10 mL). The mixture was partitioned between saturated aqueous sodium bicarbonate (50 mL) and ethyl acetate (EA, 150 mL). The aqueous layer was further extracted with ethyl acetate (50 mL). All organic layers were combined, dried and concentrated with anhydrous sodium sulfate to give a brown oily crude product. The crude product was dissolved in ethanol (EtOH, 80 mL), deionized water (53 mL) and concentrated hydrochloric acid (27 mL) were added, and stirred at 90 °C for 2 hours. After cooling to room temperature, the pH was adjusted with aqueous sodium hydroxide to 10. The aqueous layer was extracted with ethyl acetate (100 mL × 3). The organic layers were combined, dried and concentrated with anhydrous sodium sulfate. The residue was purified by fast chromatography (petroleum ether/ethyl acetate = 5/1, v/v) to afford 5-methylbenzo[d]isoxazol-3-amine as a white solid (2.5 g, 45.6% yield).
References
[1] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 169
[2] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 25
[3] Patent: US2011/112158, 2011, A1. Location in patent: Page/Page column 10
5-METHYL-1,2-BENZISOXAZOL-3-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-METHYL-1,2-BENZISOXAZOL-3-AMINE Suppliers
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-34979681; 17701870669
- Fax
- 021-34979681
- 41513101@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 55
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4985
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 027-69573188 18221423799
- 1503407886@qq.com
- Country
- China
- ProdList
- 1439
- Advantage
- 58