3-Amino-1,2-benzisoxazole
- Product Name
- 3-Amino-1,2-benzisoxazole
- CAS No.
- 36216-80-5
- Chemical Name
- 3-Amino-1,2-benzisoxazole
- Synonyms
- -3-amine, 97%;1,2-BenzisoxazoL;AKOS BBS-00002920;IFLAB-BB F1935-0009;indoxazen-3-ylamine;OTAVA-BB BB7119710108;1,2-benzoxazol-3-amine;1,2-BENZISOXAZOL-3-AMINE;benzo[d]isoxazol-3-amine;1,2-Benzoisoxazol-3-amine
- CBNumber
- CB8377634
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 36216-80-5.mol
3-Amino-1,2-benzisoxazole Property
- Melting point:
- 110 °C
- Boiling point:
- 311.6±15.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.04±0.30(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 36216-80-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-36-25
- Safety Statements
- 26-36/37/39-37/39-45
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B535183
- Product name
- 1,2-Benzisoxazol-3-amine
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB117676
- Product name
- 1,2-Benzisoxazol-3-amine
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- JK256631
- Product name
- 1,2-Benzisoxazol-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $113
- Updated
- 2021/12/16
- Product number
- FB117676
- Product name
- 1,2-Benzisoxazol-3-amine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 038100
- Product name
- 1,2-Benzisoxazol-3-amine
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
3-Amino-1,2-benzisoxazole Chemical Properties,Usage,Production
Chemical Properties
White to light brown solid
Uses
1,2-Benzisoxazol-3-amine is a useful reagent for the preparation of benzisoxazole sulfonamides useful in treatment of diseases
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 1293, 1989 DOI: 10.1002/jhet.5570260515
Synthesis
394-47-8
36216-80-5
General procedure for the synthesis of 1,2-benzisoxazol-3-amine from 2-fluorobenzonitrile: (1) Synthesis of 1,2-benzisoxazol-3-amine: potassium tert-butoxide (14.9 g, 133 mmol) was added to a solution of N,N-dimethylformamide (150 ml) containing acetohydroxamic acid (10.0 g, 133 mmol), and stirred for 30 min at room temperature. Subsequently 2-fluorobenzonitrile (18.0 g, 133 mmol) was added and the reaction continued to be stirred at room temperature for 5 hours. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was recrystallized from hexane to give 4.80 g (27.0% yield) of the target product 1,2-benzisoxazol-3-amine as a solid. The product was characterized by 1H-NMR (CDCl3): δ 4.43 (2H, br s), 7.23-7.28 (1H, m), 7.43 (1H, d, J = 9.3Hz), 7.50-7.56 (2H, m).
References
[1] Patent: EP1813606, 2007, A1. Location in patent: Page/Page column 24
[2] Journal of Organic Chemistry, 2000, vol. 65, # 10, p. 2924 - 2932
[3] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 1293 - 1298
[4] Patent: EP2460799, 2012, A1
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 18, p. 6157 - 6165
3-Amino-1,2-benzisoxazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-1,2-benzisoxazole manufacturers
- Product
- 3-Aminoisoxazole 36216-80-5
- Price
- US $3200.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-02-23
- Product
- 3-Amino-1,2-benzisoxazole 36216-80-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22