ChemicalBook > CAS DataBase List > 3-Amino-1,2-benzisoxazole

3-Amino-1,2-benzisoxazole

Product Name
3-Amino-1,2-benzisoxazole
CAS No.
36216-80-5
Chemical Name
3-Amino-1,2-benzisoxazole
Synonyms
-3-amine, 97%;1,2-BenzisoxazoL;AKOS BBS-00002920;IFLAB-BB F1935-0009;indoxazen-3-ylamine;OTAVA-BB BB7119710108;1,2-benzoxazol-3-amine;1,2-BENZISOXAZOL-3-AMINE;benzo[d]isoxazol-3-amine;1,2-Benzoisoxazol-3-amine
CBNumber
CB8377634
Molecular Formula
C7H6N2O
Formula Weight
134.14
MOL File
36216-80-5.mol
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3-Amino-1,2-benzisoxazole Property

Melting point:
110 °C
Boiling point:
311.6±15.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.04±0.30(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
36216-80-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-36-25
Safety Statements 
26-36/37/39-37/39-45
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B535183
Product name
1,2-Benzisoxazol-3-amine
Packaging
100mg
Price
$85
Updated
2021/12/16
Apolloscientific
Product number
OR25956
Product name
3-Amino-1,2-benzisoxazole
Purity
98%
Packaging
100mg
Price
$19
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK256631
Product name
1,2-Benzisoxazol-3-amine
Purity
97%
Packaging
250mg
Price
$44
Updated
2021/12/16
AK Scientific
Product number
U863
Product name
1,2-Benzisoxazol-3-amine
Packaging
1g
Price
$61
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB117676
Product name
1,2-Benzisoxazol-3-amine
Packaging
250mg
Price
$85
Updated
2021/12/16
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3-Amino-1,2-benzisoxazole Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

1,2-Benzisoxazol-3-amine is a useful reagent for the preparation of benzisoxazole sulfonamides useful in treatment of diseases

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 1293, 1989 DOI: 10.1002/jhet.5570260515

Synthesis

394-47-8

36216-80-5

General procedure for the synthesis of 1,2-benzisoxazol-3-amine from 2-fluorobenzonitrile: (1) Synthesis of 1,2-benzisoxazol-3-amine: potassium tert-butoxide (14.9 g, 133 mmol) was added to a solution of N,N-dimethylformamide (150 ml) containing acetohydroxamic acid (10.0 g, 133 mmol), and stirred for 30 min at room temperature. Subsequently 2-fluorobenzonitrile (18.0 g, 133 mmol) was added and the reaction continued to be stirred at room temperature for 5 hours. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was recrystallized from hexane to give 4.80 g (27.0% yield) of the target product 1,2-benzisoxazol-3-amine as a solid. The product was characterized by 1H-NMR (CDCl3): δ 4.43 (2H, br s), 7.23-7.28 (1H, m), 7.43 (1H, d, J = 9.3Hz), 7.50-7.56 (2H, m).

References

[1] Patent: EP1813606, 2007, A1. Location in patent: Page/Page column 24
[2] Journal of Organic Chemistry, 2000, vol. 65, # 10, p. 2924 - 2932
[3] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 1293 - 1298
[4] Patent: EP2460799, 2012, A1
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 18, p. 6157 - 6165

3-Amino-1,2-benzisoxazole Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Ethanol 2-Fluorobenzonitrile Potassium carbonate Diethyl ether Acetone oxime

Preparation Products

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View Lastest Price from 3-Amino-1,2-benzisoxazole manufacturers

R&D Scientific Inc.
Product
3-Aminoisoxazole 36216-80-5
Price
US $3200.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-02-23
Career Henan Chemical Co
Product
3-Amino-1,2-benzisoxazole 36216-80-5
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

36216-80-5, 3-Amino-1,2-benzisoxazoleRelated Search:

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  • OTAVA-BB BB7119710108
  • 2,3-dihydro-1,2-benzoxazol-3-amine
  • AKOS BBS-00002920
  • 1,2-BENZISOXAZOL-3-AMINE
  • IFLAB-BB F1935-0009
  • BENZO[D]ISOXAZOL-3-YLAMINE
  • 3-Amino-1,2-benzisoxazole
  • 3-Amino-1,2-benzisoxazole 97%
  • 1,2-Benzisoxazol-3-amine ,97%
  • 1,2-Benzoisoxazol-3-amine
  • benzo[d]isoxazol-3-amine
  • 1,2-benzisoxazol-3-amine(SALTDATA: FREE)
  • 1,2-Benzisoxazol-3-amine, Benzo[d]isoxazol-3-amine
  • 1,2-benzoxazol-3-amine
  • 1,2-Benzisoxazole, 3-amino-
  • indoxazen-3-ylamine
  • 3-Amino-1,2-benzisoxazole97%
  • 1,2-BenzisoxazoL
  • -3-amine, 97%
  • 1, 2-benzisoxazole-3-amine
  • 36216-80-5
  • Amines
  • Fused Ring Systems