6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE
- Product Name
- 6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE
- CAS No.
- 177995-39-0
- Chemical Name
- 6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE
- Synonyms
- 3-Amino-6-bromobenzisoxazole;6-broMo-1,2-benzoxazol-3-aMine;6-BROMOBENZO[D]ISOXAZOL-3-AMINE;6-Bromo-1,2-benzisoxazol-3-amine;3-AMino-6-broMobenzo[d]isoxazole;3-Amino-6-bromo-1,2-benzisoxazole;1,2-Benzisoxazol-3-amine,6-bromo-
- CBNumber
- CB51091675
- Molecular Formula
- C7H5BrN2O
- Formula Weight
- 213.03
- MOL File
- 177995-39-0.mol
6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE Property
- Boiling point:
- 371.1±22.0 °C(Predicted)
- Density
- 1.804±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.72±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B807853
- Product name
- 6-Bromobenzo[D]isoxazol-3-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W005980
- Product name
- 6-Bromobenzo[d]isoxazol-3-amine
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
- Product number
- FB53367
- Product name
- 6-Bromobenzo[d]isoxazol-3-ylamine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB53367
- Product name
- 6-Bromobenzo[d]isoxazol-3-ylamine
- Packaging
- 250mg
- Price
- $97.5
- Updated
- 2021/12/16
- Product number
- 4H56-9-L0
- Product name
- 6-Bromo-1,2-benzisoxazol-3-amine
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE Chemical Properties,Usage,Production
Uses
6-Bromobenzo[D]Isoxazol-3-Amine is a useful research reagent for organic synthesis.
Synthesis
546-88-3
105942-08-3
177995-39-0
Step A: 6-Bromobenzo[d]isoxazol-3-amine (1.13 g, 15.0 mmol) and N-hydroxyacetamide were dissolved in N,N-dimethylformamide (DMF, 20 mL). Potassium tert-butoxide (KOt-Bu, 1.68 g, 15.0 mmol) was added to the reaction system and stirred at room temperature for 30 min. Subsequently, 4-bromo-2-fluorobenzonitrile (2.0 g, 10.0 mmol) was added and the reaction was continued at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (50 mL) and water (50 mL). The aqueous layer was separated and extracted with ethyl acetate. The organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using ethyl acetate/hexane (1:4, v/v) and ethyl acetate/hexane (1:3, v/v) sequentially as eluent to afford the target compound 3-amino-6-bromobenzo[D]isoxazole (1.35 g, 63% yield). Mass spectra (APCI) m/z: 215.2, 217.1 ([M+H]+).
References
[1] Tetrahedron Letters, 1996, vol. 37, # 17, p. 2885 - 2886
[2] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2010/51042, 2010, A1. Location in patent: Page/Page column 135
[4] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00502
[5] Patent: US2014/357651, 2014, A1. Location in patent: Paragraph 0485
6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE manufacturers
- Product
- 6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE 177995-39-0
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20
- Product
- 6-BROMOBENZO[D]ISOXAZOL-3-YLAMINE 177995-39-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06