5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE

Product Name: 5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE
CAS No.: 177210-33-2
Chemical Name: 5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE
Synonyms: RMA-4177;5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE;2H-1,4-Benzoxazin-3(4H)-one, 5-hydroxy-;5-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one
CBNumber: CB62453721
Molecular Formula: C8H7NO3
Formula Weight: 165.15
MOL File: 177210-33-2.mol

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5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE Property

Boiling point:: 390.8±42.0 °C(Predicted)
Density: 1.396±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 8.69±0.20(Predicted)

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H952853
Product name: 5-Hydroxy-2h-1,4-benzoxazin-3(4h)-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR907081
Product name: 5-Hydroxy-2H-1,4-benzoxazin-3(4h)-one
Purity: 96%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 072412
Product name: 5-Hydroxy-2H-1,4-benzoxazin-3(4H)-one
Purity: 95+%
Packaging: 250mg
Price: $324
Updated: 2021/12/16

Apolloscientific

Product number: OR907081
Product name: 5-Hydroxy-2H-1,4-benzoxazin-3(4h)-one
Purity: 96%
Packaging: 1g
Price: $365
Updated: 2021/12/16

Matrix Scientific

Product number: 072412
Product name: 5-Hydroxy-2H-1,4-benzoxazin-3(4H)-one
Purity: 95+%
Packaging: 1g
Price: $700
Updated: 2021/12/16

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5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE Chemical Properties,Usage,Production

Synthesis

3163-15-3

79-04-9

177210-33-2

General procedure for the synthesis of 5-hydroxy-2H-1,4-benzoxazin-3(4H)-ones from 2-aminoresorcinol and chloroacetyl chloride: 2-aminobenzene-1,3-diol (2.0 g, 16.0 mmol) and triethylamine (TEA, 1.94 g, 19.2 mmol) were dissolved in anhydrous N,N-dimethylformamide (DMF, 30 mL) and stirred until completely dissolved. 2-Chloroacetyl chloride (1.81 g, 16.0 mmol) was slowly added dropwise with stirring, and the reaction mixture was stirred for 16 hours at room temperature. Subsequently, potassium carbonate (K2CO3, 2.65 g, 19.2 mmol) was added and the mixture was stirred at the same temperature for another 16 hours. Upon completion of the reaction, the mixture was diluted with dichloromethane (DCM, 100 mL), washed twice sequentially with water and then with saturated brine. The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The obtained residue was purified by silica gel column chromatography to afford the target product 5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (1.7 g, 64% yield).LCMS (m/z): 166.1 [M + H]+.

References

[1] Patent: WO2014/100730, 2014, A1. Location in patent: Paragraph 00345
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2641 - 2653
[3] Patent: WO2011/120604, 2011, A1. Location in patent: Page/Page column 98; 99; 136
[4] Patent: EP2377850, 2011, A1. Location in patent: Page/Page column 31
[5] Patent: WO2014/100734, 2014, A1. Location in patent: Paragraph 00326

5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE Suppliers

China 23 Germany 1 India 2 United States 6 Global 32

NovoChemy Ltd.

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Hefei Molake Biotechnology Co., Ltd.

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Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

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177210-33-2, 5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONERelated Search:

5-Hydroxypyrimidine METHYL-5-METHOXY-2-METHYLBENZOATE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-OL 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Ethyl 5-hydroxypyrazine-2-carboxylate 2H-1,4-BENZOXAZIN-3(4H)-ONE 5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE

5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE

5-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one

2H-1,4-Benzoxazin-3(4H)-one, 5-hydroxy-

RMA-4177

177210-33-2